Regulation of Matrix Metalloproteinase Gene Expression

Fini, M. Elizabeth; Cook, Jacob; Mohan, Royce

doi:10.1016/b978-012545090-4/50013-6

Cited by 147 publications

(142 citation statements)

References 240 publications

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“…As a family, the MMPs are capable of digesting all of the important structural components of extracellular matrix (8). Accordingly, in healthy states, MMP expression and activation are tightly regulated at multiple different levels.…”

Section: Discussionmentioning

confidence: 99%

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Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases from Human Chondrocytes Requires Mitogen-Activated Protein Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathways

et al. 2004

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Section: Discussionmentioning

confidence: 99%

“…Instead, we have shown that cartilage degradation in Lyme arthritis is due to induction of a class of host enzymes called matrix metalloproteinases (MMPs) (13,20). All MMPs share a common function of extracellular matrix degradation (8). In normal tissues, they are thought to play a major role in tissue growth and remodeling.…”

mentioning

confidence: 99%

Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases from Human Chondrocytes Requires Mitogen-Activated Protein Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathways

et al. 2004

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“…There are a number of regulatory mechanisms that can influence the ultimate impact of an MMP on extracellular matrix degradation. It appears that, for most MMPs, the key step is a transcriptional regulation because most MMP genes are expressed only when there is active physiological or pathological tissue remodeling taking place (Matrisian 1990;Fini et al 1998). Expression of gelatinase B is also regulated primarily at the transcription level.…”

Section: Discussionmentioning

confidence: 99%

Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

et al. 2002

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The matrix metalloproteinases appear to play an important role in the development and progression of atherosclerotic lesions. We studied the C-1562T polymorphism of the gelatinase B promoter in relation to coronary artery disease and restenosis after a percutaneous coronary intervention (PCI) in Koreans. To determine the frequency of the C-1562T allele, we examined 63 patients with coronary artery disease who underwent both PCI and 6-month follow-up coronary angiograms (CAGs), and 67 control patients with a normal CAG with respect to their clinical data and genotype. Frequencies of the C/C homozygotes and the non-C/C heterozygotes and homozygotes (C/T and T/T) were 94% and 6% in the normal CAG group, and 76.2% and 23.8% in the patient group, respectively. This gave a relative risk of 0.203 (95% CI: 0.063-0.651, P ϭ 0.005) for coronary artery disease when the C/C genotype was compared with the non-C/C genotype. In the patient groups, the allele frequencies of the C/C and non-C/C were 80% and 20% in the nonrestenotic subgroup, and 71.4% and 28.6% in the restenotic subgroup (P ϭ 0.554). No T/T homozygote was found in any of the groups. We conclude that C/C homozygosity is a potential genetic protective factor for coronary artery disease in Koreans.

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“…MMPs play major physiological roles in degrading and remodeling the ECM. The presence of a clone encoding gelatinase-B (B66) is significant, because MMP-9 has been shown to be expressed in wounded corneal epithelium and is implicated in corneal ulceration and graft rejection (Berman, 1989;Fini et al, 1995Fini et al, , 1996Fini et al, , 1998Barro et al, 1998;Ye and Azar, 1998;Carinato et al, 2000). MMPs have also been implicated in regeneration (Yang and Bryant, 1994;Yang et al, 1997).…”

Section: A Profile Of Gene Expression In Transdifferentiating Cornea mentioning

confidence: 99%

Characterizing gene expression during lens formation in Xenopus laevis: Evaluating the model for embryonic lens induction

Henry

Carinato

Schaefer

et al. 2002

Developmental Dynamics

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Few directed searches have been undertaken to identify the genes involved in vertebrate lens formation. In the frog Xenopus, the larval cornea can undergo a process of transdifferentiation to form a new lens once the original lens is removed. Based on preliminary evidence, we have shown that this process shares many elements of a common molecular/genetic pathway to that involved in embryonic lens development. A subtracted cDNA library, enriched for genes expressed during cornea-lens transdifferentiation, was prepared. The similarities/identities of specific clones isolated from the subtracted cDNA library define an expression profile of cells undergoing cornea-lens transdifferentiation ("lens regeneration") and corneal wound healing (the latter representing a consequence of the surgery required to trigger transdifferentiation). Screens were undertaken to search for genes expressed during both transdifferentiation and embryonic lens development. Significantly, new genes were recovered that are also expressed during embryonic lens development. The expression of these genes, as well as others known to be expressed during embryonic development in Xenopus, can be correlated with different periods of embryonic lens induction and development, in an attempt to define these events in a molecular context. This information is considered in light of our current working model of embryonic lens induction, in which specific tissue properties and phases of induction have been previously defined in an experimental context. Expression data reveal the existence of further levels of complexity in this process and suggests that individual phases of lens induction and specific tissue properties are not strictly characterized or defined by expression of individual genes.

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Regulation of Matrix Metalloproteinase Gene Expression

Cited by 147 publications

References 240 publications

Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases from Human Chondrocytes Requires Mitogen-Activated Protein Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathways

Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases from Human Chondrocytes Requires Mitogen-Activated Protein Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathways

Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

Characterizing gene expression during lens formation in Xenopus laevis: Evaluating the model for embryonic lens induction

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