Regulation of male fertility by pyrimethamine in adult mice

Kalla, N.R.; Saggar, Surinder; Puri, Rajeev K.; Mehta, Uma

doi:10.1007/s004330050054

Cited by 8 publications

(9 citation statements)

References 11 publications

(17 reference statements)

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“…Several reports indicated that anti-Toxoplasma drugs, particularly pyrimethamine, have adverse effects on male reproductive function (55)(56)(57)(58)(59)(60)(61)(62)(63). According to experimental studies in male mice and rats, different fertility parameters, like sperm motility and sperm counts were significantly decreased in pyrimethamine treated animals.…”

Section: Drugs Use In Treatment Of Toxoplasmosis Affects Male Reprodumentioning

confidence: 99%

“…According to experimental studies in male mice and rats, different fertility parameters, like sperm motility and sperm counts were significantly decreased in pyrimethamine treated animals. In addition, structure of testes and epididymis were altered in treated animals compare to control group (55)(56)(57). Other studies suggested, pyrimethamine have mutagenesis effects in germ cells of mice testes and can cause reduction in synthesis of DNA in spermatogonia cells (58,59).…”

Section: Drugs Use In Treatment Of Toxoplasmosis Affects Male Reprodumentioning

confidence: 99%

See 1 more Smart Citation

Toxoplasma gondii and Male Reproduction Impairment: A new Aspect of Toxoplasmosis Research

Dalimi¹,

Abdoli²

2013

Jundishapur J Microbiol

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Introduction: Toxoplasma gondii is one of the most important pathogen that has adverse effect on reproductive function.Evidence Acquisition: Recent studies revealed that infection with T. gondii not only affect female reproduction, also cause male reproductive impairment. In clinical studies, high prevalence of toxoplasmosis in sterile men has been reported. In animal models, toxoplasmosis is associated with male reproductive impairment. Moreover, there are some evidences about venereal transmission of T. gondii. Drugs used for treatment of toxoplasmosis may cause adverse effects on male reproductive function.Results: In present article, effect of Toxoplasma infection on male reproductive system of human and animal was reviewed.There are several reports expressing association between Toxoplasmosis and male genital tract impairment in both human and animals.Conclusions: These findings suggest that T. gondii infection can cause temporary impairment on the reproductive parameters of human or animal male as well as impairment of different hormones which may cause insufficient male reproductivity

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Section: Drugs Use In Treatment Of Toxoplasmosis Affects Male Reprodumentioning

confidence: 99%

Section: Drugs Use In Treatment Of Toxoplasmosis Affects Male Reprodumentioning

confidence: 99%

Toxoplasma gondii and Male Reproduction Impairment: A new Aspect of Toxoplasmosis Research

Dalimi¹,

Abdoli²

2013

Jundishapur J Microbiol

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“…Unlike supplementation, folate deprivation is conceivable only in animal models. Rats fed a folic acid-deficient diet showed a major reduction in sperm count (Mayr et al, 1999), whereas various dihydrofolate reductase (DHFR) inhibitors, such as etopride (Malik et al, 1995) and pyrimethamine (Cosentino et al, 1990;Kalla et al, 1997) proved to be efficient male contraceptives in mice and rats, by significantly reducing sperm count as well as motility. Given the key role of MTHFR in folate metabolism, the most interesting animal model is the MTHFR knock out mouse, whose MTHFR activity has been abolished by gene targeting (Chen et al, 2001b).…”

Section: Pharmacological and Experimental Datamentioning

confidence: 99%

Impact of folate and homocysteine metabolism on human reproductive health

Forges

Monnier‐Barbarino

Alberto

et al. 2007

Human Reproduction Update

244

188

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Folates belong to the vitamin B group and are involved in a large number of biochemical processes, particularly in the metabolism of homocysteine. Dietary or genetically determined folate deficiency leads to mild hyperhomocysteinemia, which has been associated with various pathologies. Molecular mechanisms of homocysteine-induced cellular dysfunction include increased inflammatory cytokine expression, altered nitric oxide bioavailability, induction of oxidative stress, activation of apoptosis and defective methylation. Whereas the involvement of folate metabolism and homocysteine in ageing-related diseases, in several developmental abnormalities and in pregnancy complications has given rise to a large amount of scientific work, the role of these biochemical factors in the earlier stages of mammalian reproduction and the possible preventive effects of folate supplementation on fertility have, until recently, been much less investigated. In the present article, the possible roles of folates and homocysteine in male and female subfertility and related diseases are systematically reviewed, with regard to the epidemiological, pathological, pharmacological and experimental data of the literature from the last 25 years.

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“…De même, l'usage d'inhibiteurs de la DHFR qui interrompent le recyclage des folates (Fig. 1), entraînait une diminution de la numération et de la mobilité des spermatozoïdes chez le rat et la souris [28][29][30]. Dans un modèle de rat carencé à la fois en vitamines B2, B9, B12 et choline pendant un mois avant l'accouplement, nous avons montré récemment le maintien d'une fertilité chez les femelles, mais les ratons exposés à ce régime in utero et durant l'allaitement présentaient un retard de croissance important et une mortalité périnatale de 25 % [31].…”

Section: Données Expérimentalesunclassified