Les folates : quel impact sur la fertilité ?

Forges, Thierry; Pellanda, Hélène; Diligent, Catherine; Monnier, Patricia; Guéant, Jean‐Louis

doi:10.1016/j.gyobfe.2008.07.004

Cited by 12 publications

(4 citation statements)

References 120 publications

(115 reference statements)

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“…In all organisms, folates are involved in key metabolic pathways, such as amino acid and nucleotide biosynthesis. Therefore, by impacting cells with high mitotic activity, they are thought to affect initial events of reproduction from gametogenesis to early embryonic development, and indeed, folate deficiency causes reduced fertility in rats [13].…”

Section: Resultsmentioning

confidence: 99%

Rapid Establishment of Genetic Incompatibility through Natural Epigenetic Variation

et al. 2012

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Epigenetic variation is currently being investigated with the aim of deciphering its importance in both adaptation and evolution [1]. In plants, epimutations can underlie heritable phenotypic diversity [2-4], and epigenetic mechanisms might contribute to reproductive barriers between [5] or within species [6]. The extent of epigenetic variation begins to be appreciated in Arabidopsis [7], but the origin of natural epialleles and their impact in the wild remain largely unknown. Here we show that a genetic incompatibility among Arabidopsis thaliana strains is related to the epigenetic control of a pair of duplicate genes involved in fitness: a transposition event results in a rearranged paralogous structure that causes DNA methylation and transcriptional silencing of the other copy. We further show that this natural, strain-specific epiallele is stable over numerous generations even after removal of the duplicated, rearranged gene copy through crosses. Finally, we provide evidence that the rearranged gene copy triggers de novo DNA methylation and silencing of the unlinked native gene by RNA-directed DNA methylation. Our findings suggest an important role of naturally occurring epialleles originating from structural variation in rapidly establishing genetic incompatibilities following gene duplication events.

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Section: Resultsmentioning

confidence: 99%

Rapid Establishment of Genetic Incompatibility through Natural Epigenetic Variation

et al. 2012

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“…Folates are group B vitamins that play essential roles in cell metabolism, including the synthesis of nucleic acids and epigenetic regulation of gene expression through remethylation of homocysteine into methionine [32]. Impaired folate status has been associated with several pathologies such as cardiovascular, neurodegenerative diseases and pregnancy complications [32].…”

Section: Discussionmentioning

confidence: 99%

“…Impaired folate status has been associated with several pathologies such as cardiovascular, neurodegenerative diseases and pregnancy complications [32]. Recent studies suggest that the key enzymes in folate metabolism are critical for male spermatogenesis [24,33].…”

Section: Discussionmentioning

confidence: 99%

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

et al. 2015

J Assist Reprod Genet

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Purpose This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folaterelated enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. Methods The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. Results We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. Conclusions There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.

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“…Вважається, що ФК забезпечує профiлактику глибоких венозних тромбозiв та емболiй. ФК важлива для нормальних процесiв росту, розвитку i пролiферацiї тканин, у тому числi й для еритропоезу та ембрiогенезу [16,17]. Крiм того, частина дослiдникiв прийшла до єдиного висновку, що дефiцит фолатiв та асоцiйований з ним пiдвищений вмiст ГЦ в сироватцi кровi та фолiкулярнiй рiдини призводить до порушення розвитку фолiкула i дозрiвання яйцеклiтини, порушення оварiального резерву та настання вагiтностi [18,19].…”

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The Levels of Folic Acid and Homocysteine in the Blood of Women With Polycystic Ovary Syndrome and the Dynamics of These Indicators During of Folate Therapy

Arkhypkina

Karachentsev

Bondarenko

et al. 2016

PEP

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It were examined 70 young women with PCOS. It was established, that these patients have lower levels of folic acid than healthy women, 47 % — reduction below reference values of norms, 52.8 % — hyperhomocysteinemia. Folic acid treatment at a dose of 5 mg/day helped to normalize its levels for 12 week therapy at that at women with normal body weight normalization was faster. The concentration of homocysteine during treatment as high as indicators of healthy women at patients with normal weight for 12 weeks of therapy, and at patients with obesity — for 24 weeks. Determination in blood levels of folate and homocysteine should be included a comprehensive examination of this category of patients, particularly at the stage pregravid period.

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Les folates : quel impact sur la fertilité ?

Cited by 12 publications

References 120 publications

Rapid Establishment of Genetic Incompatibility through Natural Epigenetic Variation

Rapid Establishment of Genetic Incompatibility through Natural Epigenetic Variation

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

The Levels of Folic Acid and Homocysteine in the Blood of Women With Polycystic Ovary Syndrome and the Dynamics of These Indicators During of Folate Therapy

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