Regulation of Magnesium Matrix Composites Materials on Bone Immune Microenvironment and Osteogenic Mechanism

Nie, Xiaojing; Zhang, Xueyan; Lei, Baozhen; Shi, Yonghua; Yang, Jingshuai

doi:10.3389/fbioe.2022.842706

Cited by 10 publications

(7 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been determined that the optimal concentration range for magnesium ions is between 6 mmol/L and 10 mmol/L, 50 which significantly enhances the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by activating the MAPK/ERK signaling pathway. 51 , 52 The composite hydrogel synthesized in this study has long-term stable magnesium ion release characteristics, so it will have a positive impact on the application of bone tissue.…”

Section: Results and Discussionmentioning

confidence: 99%

Magnesium-Doped Nano-Hydroxyapatite/Polyvinyl Alcohol/Chitosan Composite Hydrogel: Preparation and Characterization

Zhang,

Liu,

Zhao

et al. 2024

IJN

View full text Add to dashboard Cite

Background Polyvinyl alcohol/Chitosan hydrogel is often employed as a carrier because it is non-toxic, biodegradable, and has a three-dimensional network structure. Meanwhile, Magnesium-doped nano-hydroxyapatite(Mg-nHA) demonstrated high characterization to promote the osteogenic differentiation of bone marrow derived mesenchymal stem cell(BMSCs). Therefore, in order to develop a porous hydrogel scaffold for the application of bone tissue engineering, an appropriate-type Mg-nHA hydrogel scaffold was developed and evaluated. Methods A composite hydrogel containing magnesium-doped nano-hydroxyapatite (Mg-nHA/PVA/CS) was developed using a magnetic stirring-ion exchange method and cyclic freeze-thaw method design, with polyvinyl alcohol and chitosan as the main components. Fourier transform infrared spectra (FTIR), electron energy dispersive spectroscopy (EDS), X-ray photoelectron spectrometer (XPS) and scanning electron microscopy (SEM) were employed to analyze the chemical structure, porosity, and elemental composition of each hydrogels. The equilibrium swelling degree, moisture content, pH change, potential for biomineralization, biocompatibility, the osteogenic potential and magnesium ion release rate of the composite hydrogel were also evaluated. Results SEM analysis revealed a well-defined 3D spatial structure of micropores in the synthesised hydrogel. FTIR analysis showed that doping nanoparticles had little effect on the hydrogel’s structure and both the 5% Mg-nHA/PVA/CS and 10% Mg-nHA/PVA/CS groups promoted amide bond formation. EDS observation indicated that the new material exhibited favourable biomineralization ability, with optimal performance seen in the 5% Mg-nHA/PVA/CS group. The composite hydrogel not only displayed favourable water content, enhanced biocompatibility, and porosity (similar to human cancellous bone), but also maintained an equilibrium swelling degree and released magnesium ions that created an alkaline environment around it. Additionally, it facilitated the proliferation of bone marrow mesenchymal stem cells and their osteogenic differentiation. Conclusion The Mg-nHA/PVA/CS hydrogel demonstrates significant potential for application in the field of bone repair, making it an excellent composite material for bone tissue engineering.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Magnesium-Doped Nano-Hydroxyapatite/Polyvinyl Alcohol/Chitosan Composite Hydrogel: Preparation and Characterization

Zhang,

Liu,

Zhao

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

“…Magnesium (Mg) is a degradable and absorbable biomaterial. It is widely used in the clinic as its structural and mechanical characteristics are similar to those of the trabecular bone, which is beneficial to obtaining early fixation (84). Mg homeostasis in cells is maintained by Mg channels and transporters, including Mrs2, SLC41A1, SLC41A2, and TRPM6 (82).…”

Section: Magnesiummentioning

confidence: 99%

NLRP3 inflammasome activation in response to metals

Huang

Zhang²,

Qiu³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Implant surgery is followed by a series of inflammatory reactions that directly affect its postoperative results. The inflammasome plays a vital role in the inflammatory response by inducing pyroptosis and producing interleukin-1β, which plays a critical role in inflammation and tissue damage. Therefore, it is essential to study the activation of the inflammasome in the bone healing process after implant surgery. As metals are the primary implant materials, metal-induced local inflammatory reactions have received significant attention, and there has been more and more research on the activation of the NLRP3 (NOD-like receptor protein-3) inflammasome caused by these metals. In this review, we consolidate the basic knowledge on the NLRP3 inflammasome structures, the present knowledge on the mechanisms of NLRP3 inflammasome activation, and the studies of metal-induced NLRP3 inflammasome activation.

show abstract

“…Surface treatment has been an effective strategy for regulating degradation rates in recent years (Li and Zheng, 2013). Moreover, the preparation of Mg metal matrix composites (MMC) by adding reinforcing particles is another novel method to improve the degradation resistance (Dezfuli et al, 2017a;Dezfuli et al, 2017b;Kumar et al, 2019;Nie et al, 2022). However, these two measures for improving the corrosion performance of AM-Mg are currently less studied.…”

Section: Typical Strategies To Improve the Corrosion Resistance Of Mg...mentioning

confidence: 99%

“…Consequently, it was determined that hatch spacing and scanning speed adversely affect the hole size and shape, respectively ( Yan et al, 2021 ]. Ng et al (2011a) investigated the effects of different pulsed and continuous wave laser powers on the microstructure of specimens, demonstrating that reduced power contributed to grain refinement. The grain size of the samples shaped with a continuous wave was significantly smaller than that of a pulsed wave for a similar average energy density.…”

Section: Current Status Of the Biomechanical Properties Of Am Mg Allo...mentioning

confidence: 99%

Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives

et al. 2022

View full text Add to dashboard Cite

Bone defect repair is a complicated clinical problem, particularly when the defect is relatively large and the bone is unable to repair itself. Magnesium and its alloys have been introduced as versatile biomaterials to repair bone defects because of their excellent biocompatibility, osteoconductivity, bone-mimicking biomechanical features, and non-toxic and biodegradable properties. Therefore, magnesium alloys have become a popular research topic in the field of implants to treat critical bone defects. This review explores the popular Mg alloy research topics in the field of bone defects. Bibliometric analyses demonstrate that the degradation control and mechanical properties of Mg alloys are the main research focus for the treatment of bone defects. Furthermore, the additive manufacturing (AM) of Mg alloys is a promising approach for treating bone defects using implants with customized structures and functions. This work reviews the state of research on AM-Mg alloys and the current challenges in the field, mainly from the two aspects of controlling the degradation rate and the fabrication of excellent mechanical properties. First, the advantages, current progress, and challenges of the AM of Mg alloys for further application are discussed. The main mechanisms that lead to the rapid degradation of AM-Mg are then highlighted. Next, the typical methods and processing parameters of laser powder bed fusion fabrication on the degradation characteristics of Mg alloys are reviewed. The following section discusses how the above factors affect the mechanical properties of AM-Mg and the recent research progress. Finally, the current status of research on AM-Mg for bone defects is summarized, and some research directions for AM-Mg to drive the application of clinical orthopedic implants are suggested.

show abstract

Regulation of Magnesium Matrix Composites Materials on Bone Immune Microenvironment and Osteogenic Mechanism

Cited by 10 publications

References 72 publications

Magnesium-Doped Nano-Hydroxyapatite/Polyvinyl Alcohol/Chitosan Composite Hydrogel: Preparation and Characterization

Magnesium-Doped Nano-Hydroxyapatite/Polyvinyl Alcohol/Chitosan Composite Hydrogel: Preparation and Characterization

NLRP3 inflammasome activation in response to metals

Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives

Contact Info

Product

Resources

About