1992
DOI: 10.1016/0141-1136(92)90113-z
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Regulation of hepatic glutathione S-transferase expression in flounder

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Cited by 17 publications
(5 citation statements)
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“…Fish liver glutathione S-transferase-A cDNA characterization and expression observed in the closely related flounder, Platichthysflesus (Scott et al, 1992). We have also observed in the flounder that inducers such as the polyaromatic hydrocarbon 3-methylcholanthrene, which act at the [Ah] locus (Nebert et al, 1990), do not affect or may even suppress mRNA for GST-A in this species, whereas trans-stilbene oxide induces GST-A mRNA in both plaice and flounder (Scott et al, 1992).…”
Section: Discussionmentioning
confidence: 62%
See 1 more Smart Citation
“…Fish liver glutathione S-transferase-A cDNA characterization and expression observed in the closely related flounder, Platichthysflesus (Scott et al, 1992). We have also observed in the flounder that inducers such as the polyaromatic hydrocarbon 3-methylcholanthrene, which act at the [Ah] locus (Nebert et al, 1990), do not affect or may even suppress mRNA for GST-A in this species, whereas trans-stilbene oxide induces GST-A mRNA in both plaice and flounder (Scott et al, 1992).…”
Section: Discussionmentioning
confidence: 62%
“…Fish liver glutathione S-transferase-A cDNA characterization and expression observed in the closely related flounder, Platichthysflesus (Scott et al, 1992). We have also observed in the flounder that inducers such as the polyaromatic hydrocarbon 3-methylcholanthrene, which act at the [Ah] locus (Nebert et al, 1990), do not affect or may even suppress mRNA for GST-A in this species, whereas trans-stilbene oxide induces GST-A mRNA in both plaice and flounder (Scott et al, 1992). This spectrum of inducer action differs from that observed in mammals, where both trans-stilbene oxide and polyaromatic hydrocarbons induce the Alpha class GST-1 of rats and Mu class GST of mouse (DiSimplicio et al, 1989;Hayes et al, 1991;Rushmore et al, 1991), again supporting the conclusion from the sequence, substrate specificity, ligand binding and immunological data (above and George and Buchanan, 1990;George et al, 1989) that plaice GST-A is not an Alpha or Mu class orthologue.…”
Section: Discussionmentioning
confidence: 62%
“…As GST são predominantemente enzimas de fração citosólica (95%), e uma pequena porção (5%) pertence à fração microssomal (retículo endoplasmático) e mitocondrial. As GSTs estão largamente distribuídas na natureza, podendo ser encontradas em plantas, bactérias, moluscos, insetos, peixes, anfíbios e mamíferos (RODRIGUES, 2003 Muitos estudos que analisaram a GST em fígado de peixe expostos a diferentes tipos inseticidas mostraram uma indução enzimática (ANDERSSON et al, 1985;LEAVER et al, 1992;RODRIGUEZ-ARIZA et al, 1991;SCOTT et al, 1992).…”
Section: 23) Atividade Da Glutationa S-transferaseunclassified
“…Segundo SCOTT et al (1992), linguados expostos a 3-MC (3-metilcolantreno) tiveram a glutationa S-transferase hepática reduzida sugerindo inibição do metabolismo, acredita-se que muitas variações entre populações de peixes nativos e entre a relação dose / resposta pode ser encontrada.…”
Section: E Emunclassified
“…There are reports indicating the role of induced GST activity in protection against the toxicity of xenobiotic-induced lipid peroxidation (Leaver and George, 1998). Many studies analysing GST activity in liver of fish exposed to different insecticides showed an enzymatic induction (Andersson et al, 1985;Rodriguez-Ariza et al, 1991;Leaver et al, 1992;Scott et al, 1992). Metabolites formed from detoxification of foreign compounds act as substrates for GST and modify the microsomal glutathione transferase covalently.…”
Section: Resultsmentioning
confidence: 99%