Regulation of feline aggression by the bed nucleus of stria terminalis

Shaikh, Majid B.; Brutus, Martin; Siegel, Heidi E.; Siegel, Allan

doi:10.1016/0361-9230(86)90031-6

Cited by 66 publications

(27 citation statements)

References 17 publications

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“…Recent work suggests that dopamine D1 receptor function is reduced in the S lines Rhodes et al, 2001) and other studies have implicated dopamine in predatory aggression in rodents and carnivores (ferrets) (Baggio and Ferrari, 1980;Jimerson and Reis, 1973;Schmidt, 1979;Schmidt, 1983;Siegel et al, 1999). Dopamine facilitates predatory aggression, possibly via D2 receptors, in some studies (Shaikh et al, 1986;Siegel et al, 1999), yet dopamine receptor antagonists also facilitate this behavior in other studies (Baggio and Ferrari, 1980;Schmidt, 1979;Schmidt, 1983). These varying results suggest it will be critical to understand exactly where in the brain and at what levels dopamine is released (or inhibited from release) to determine how dopamine is involved in predatory aggression.…”

Section: Discussionmentioning

confidence: 95%

Predatory aggression, but not maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice

Gammie

Hasen

Rhodes

et al. 2003

Hormones and Behavior

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Section: Discussionmentioning

confidence: 95%

Predatory aggression, but not maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice

Gammie

Hasen

Rhodes

et al. 2003

Hormones and Behavior

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“…In cats, the medial amygdala and its major output region 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 BNST inhibit predatory attacks, whereas the central and basolateral nuclei facilitate this response [1,[42][43][44][45][46]. Our findings are in line with these reports by showing a muricide-specific activation of the central and basolateral nuclei.…”

Section: Comparisons With Earlier Findingsmentioning

confidence: 99%

Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Tulogdi

Biró

Barsvári

et al. 2015

Behavioural Brain Research

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Our recent studies showed that brain areas that are activated in a model of escalated aggression overlap with those that promote predatory aggression in cats. This finding raised the interesting possibility that the brain mechanisms that control certain types of abnormal aggression include those involved in predation. However, the mechanisms of predatory aggression are poorly known in rats, a species that is in many respects different from cats. To get more insights into such mechanisms, here we studied the brain activation patterns associated with spontaneous muricide in rats. Subjects not exposed to mice, and those which did not show muricide were used as controls. We found that muricide increased the activation of the central and basolateral amygdala, and lateral hypothalamus as compared to both controls; in addition, a ventral shift in periaqueductal gray activation was observed.Interestingly, these are the brain regions from where predatory aggression can be elicited, or enhanced by electrical stimulation in cats. The analysis of more than 10 other brain regions showed that brain areas that inhibited (or were neutral to) cat predatory aggression were not affected by muricide. Brain activation patterns partly overlapped with those seen earlier in the cockroach hunting model of rat predatory aggression, and were highly similar with those observed in the glucocorticoid dysfunction model of escalated aggression. These findings show that the brain mechanisms underlying predation are evolutionarily conservative, and indirectly support our earlier assumption regarding the involvement of predation-related brain mechanisms in certain forms of escalated social aggression in rats.

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“…Of interest, most brain regions activated in SUB males and implicated in excitatory regulation of the HPA axis have also been shown to play a facilitatory role in stress-induced behavior: CeA (Jellestad et al, 1986), BNST (Shaikh et al, 1986;Casada and Dafny, 1991), MPOA (Gonzalez et al, 1996), lateral septum (Pesold and Treit, 1992), DR (for review, see Graeff, 1994), and LC (for review, see Bremner et al, 1996). Furthermore, the pattern of activation after defeat mirrors the distribution of Fos protein after electrical stimulation of brain regions that elicit aversion and defense (Silveira et al, 1993(Silveira et al, , 1995 or after behavioral or conditioning paradigms associated with increased anxiety or fear (Silveira et al, 1994;Beck and Fibiger, 1995).…”

Section: Stress Neurocircuits: Behavioral Regulationmentioning

confidence: 99%

Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain

1997

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During an agonistic encounter, subordinate male hamsters display defensive and submissive postures and show increased secretion of glucocorticoids, whereas dominant males do not. To determine whether specific neuronal pathways are activated during the behavioral and neuroendocrine responses of subordinate males, expression of c-fos mRNA within the brains of subordinate males was compared with the pattern in dominant males after fighting. After 1 week of handling, pairs of hamsters were either swapped between cages (handled control males), or were allowed to interact for 30 min [dominant (DOM) males and subordinate (SUB) males]. A second group of control animals that received no handling or social stimulation (unhandled control males) were also included. After testing, all animals were killed by decapitation, their brains were removed for c-fos in situ hybridization, and trunk blood was collected for analysis of plasma cortisol and corticosterone levels. Exposure of males to their partner's cage for 30 min resulted in increased expression of c-fos mRNA in multiple brain regions. In addition, fighting increased c-fos expression in the medial amygdaloid nucleus of both DOM and SUB males as well as having more selective effects. In DOM males, c-fos expression was elevated within the supraoptic nucleus of the hypothalamus. In SUB males, c-fos expression increased within a multitude of brain areas, including cingulate cortex, lateral septum, bed nucleus of the stria terminalis, medial preoptic area, several hypothalamic nuclei, central amygdaloid nucleus, amygdalohippocampal area, dorsal periaqueductal gray, dorsal raphe, cuneiform nucleus, and locus coeruleus. These findings are discussed in relation to neurocircuits associated with behavioral arousal and stress.

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Regulation of feline aggression by the bed nucleus of stria terminalis

Cited by 66 publications

References 17 publications

Predatory aggression, but not maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice

Predatory aggression, but not maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice

Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain

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