Regulation of erythropoiesis in the fetus and newborn.

Finne, P. H.; Halvorsen, S

doi:10.1136/adc.47.255.683

Cited by 59 publications

(41 citation statements)

References 32 publications

(24 reference statements)

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“…The magnitude of cord serum values in our study is comparable to that reported by Thomas et al [21]. These results extend previous investigations, that demonstrated erythropoietic activity in cord blood and 1st day urine, but not during the following weeks by employing less sensitive bioassays for EPO [9]. In addition to Thomas and coworkers, who demonstrated an increase in EPO levels from 19 weeks gestation until term [21], we found a significant increase also during late gestation (Fig.…”

Section: Discussionsupporting

confidence: 92%

“…3). The importance of EPO for the regulation of fetal erythropoiesis is further supported by previous studies, demonstrating increased EPO levels in the presence of placental insufficiency and fetal hypoxia [9,21,23]. Also in the present investigation EPO levels in children with signs of fetal distress were elevated and cord blood EPO was inversely correlated with umbilical artery pH, indicating that fetal EPO production can respond to hypoxia.…”

Section: Discussionsupporting

confidence: 90%

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Serum immunoreactive erythropoietin of children in health and disease

et al. 1990

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Abstract. Serum immunoreactive erythropoietin (siEPO) was determined in cord serum from neonates (n = 97, gestational age 36-43 weeks), in healthy children from birth to adolescence (n = 260) and in children with haematological (n = 30), renal (n = 10) and congenital heart diseases (n = 70). In healthy children siEPO levels decreased after birth (geometric mean cord siEPO 35.6mU/ml with 95% range of 17-56mU/ml in eutrophic, nondistressed fetuses) and reached lowest values during the first 2 months (geometric mean siEPO ll.5mU/ ml). Thereafter siEPO levels increased slightly and were constant between 2 months and adolescence. The geometric mean siEPO for healthy children after birth was 18.8mU/ml with 95% range of 7-47 mU/ml. These estimates were not significantly different from normal adult values. In newborns with fetal distress (n = 15) cord siEPO was significantly elevated (geometric mean 63.0 mU/ml; P < 0.001). In children with haematological disease, siEPO and Hb concentration were inversely correlated (log siEPO (mU/ml)= 4.1 -0.20 x Hb (g/dl); r=-0.62; P<0.0005). This relationship was significantly different in children with chronic renal failure (log siEPO (mU/ml) = 0.67 + 0.035 • Hb (g/dl); r = 0.50; P = 0.1). In children with heart disease the geometric mean siEPO was 19.2mU/ml with 95% range 8-65 mU/ml for cyanotic (SaO2 < 94%) and 17.7 mU/ml with 95% range of 12-36 mU/ml for acyanotic patients. In this group siEPO values were inversely correlated to the arterial oxygen content (log siEPO (mU/ml) = 1.61 -2.04 x oxygen content (1/t); r = -0.28; P < 0.02).

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Serum immunoreactive erythropoietin of children in health and disease

et al. 1990

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“…3b shows the effect of varying L(0), the RBC life span at the time of birth, on the simulated BioRBC survival curve with fixed parameters of α =0, k =0.60×10 8 RBCs/day g, and no clinical phlebotomies. Figure 3c shows the effect of multiple clinical phlebotomies on the simulated BioRBC survival curve with fixed parameters of L(0) = 80 days, k = 0.60 ×10 8 RBCs/day g, and α = 0. Finally, the effect of varying k, the scaling factor associated with the fetal RBC production rate, on the model-predicted BioRBC survival curve is depicted in Fig.…”

Section: Subject Characteristicsmentioning

confidence: 99%

“…Figure 3a shows the effect of varying α, the slope associated with the rate of change in fetal RBC life span (Eq. 4), on the simulated BioRBC survival curve with all other model parameters fixed at specified values: L(0) = 80 days; k =0.60×10 8 RBCs/day g; no clinical phlebotomies. Similarly, Fig.…”

Section: Subject Characteristicsmentioning

confidence: 99%

“…During this period, the fetus experiences rapid growth, and as a result, the rate of RBC production is high (5). The progressive increase in hemoglobin (Hb) concentration and erythrocyte content in whole blood that is observed during the course of intrauterine development provides ample evidence that the RBC production increases with time in utero, leading to high Hb values at birth (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

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A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

Kuruvilla

Widness

Nalbant

et al. 2015

AAPS J

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Abstract. Fetal RBCs are produced during a period of very rapid growth and stimulated erythropoiesis under hypoxic intrauterine conditions. Fetal RBC life span varies with gestational age (GA) and is shorter than that in healthy adults. Due to the special kinetic properties of life span-based survival of human RBCs, a mathematical model-based kinetic analysis of the survival of fetal RBCs shortly after birth provides a unique opportunity to Blook backward in time^to evaluate fetal erythropoiesis. This work introduces a novel method that utilizes postnatal in vivo RBC survival data collected within 2 days after birth to study both nonsteady-state (non-SS) in utero RBC production and changing fetal RBC life span over time. The effect of changes in erythropoiesis rate and RBC life span and the effect of multiple postnatal phlebotomies on the RBC survival curves were investigated using model-based simulations. This mathematical model, which considers both changes in the rate of erythropoiesis and RBC life span and which accurately accounts for the confounding effect of multiple phlebotomies, was applied to survival curves for biotin-labeled RBCs from ten anemic very low birth weight preterm infants. The estimated mean fetal RBC production rate scaled by body weight was 1.07×107 RBCs/day g, and the mean RBC life span at birth was 52.1 days; these values are consistent with reported values. The in utero RBC life span increased at a rate of 0.51 days per day of gestation. We conclude that the proposed mathematical model and its implementation provide a flexible framework to study in utero non-SS fetal erythropoiesis in newborn infants.

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Disorders of Iron Metabolism: Iron Deficiency, Iron Overload and the Sideroblastic Anemias

Will¹

2006

Pediatric Hematology

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Regulation of erythropoiesis in the fetus and newborn.

Cited by 59 publications

References 32 publications

Serum immunoreactive erythropoietin of children in health and disease

Serum immunoreactive erythropoietin of children in health and disease

A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

Disorders of Iron Metabolism: Iron Deficiency, Iron Overload and the Sideroblastic Anemias

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