Disorders of Iron Metabolism: Iron Deficiency, Iron Overload and the Sideroblastic Anemias

Correlation between vivax malaria infection and iron deficiency in children

“…2 Iron deficiency occurs in three stages. 16,17,18 The first stage, iron depletion, occurs when iron content is not enough to meet body requirements, characterized by reduced iron deposition without functional changes, and serum ferritin <15 μg/L. The second stage, Table 3 Table 4 iron deficiency, is characterized by a reduction in serum iron, serum transferrin saturation <16%, and an increase in free erythrocyte protoporphyrin level.…”

Reference intervals for red cell variables and platelet counts in infants at 2, 5 and 13 months of age: a cohort study

“…We studied infants at 2 months of age, when erythropoietic activity begins to increase following the rapid fall in haemoglobin concentration that occurs in the first weeks of life,12 and at 5 months, an age at which endogenous iron stores begin to be depleted 13. At 13 months iron deficiency was found to be very common,11 limiting the number of subjects available for study.…”

An assessment of methods used in the investigation of iron status: findings in a population of young British South Asian children

“…Subsequent availability of sTfR values showed two children with the anaemia of inflammation to have coexisting iron deficiency. As iron deficiency is rare before 3 months and incidence declines beyond 36 months of age21 this study was mainly limited to children within this age range, with <10% aged 37–43 months. Although this study was undertaken to assess laboratory methods rather than the incidence and severity of iron deficiency in the local population, the prevalence of iron deficiency and iron deficiency anaemia were found to be similar to those previously reported in young British South Asian children 22 23.…”