Regulation of Early Light-Inducible Protein Gene Expression by Blue and Red Light in Etiolated Seedlings Involves Nuclear and Plastid Factors

Adamska, Iwona

doi:10.1104/pp.107.4.1167

Cited by 53 publications

(32 citation statements)

References 27 publications

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“…For instance, in the albostrians mutant of barley (Hordeum vulgare), which is deficient in plastid ribosomes, the expression of nuclear photosynthetic genes is drastically downregulated (Bradbeer et al, 1979;Hess et al, 1991Hess et al, , 1994. Similar effects are observed when light-or dark-adapted wildtype plants are treated with inhibitors of plastid translation (Oelmü ller et al, 1986;Adamska, 1995;Gray et al, 1995;Yoshida et al, 1998;Sullivan and Gray, 1999).…”

Section: Introductionmentioning

confidence: 93%

Nuclear Photosynthetic Gene Expression Is Synergistically Modulated by Rates of Protein Synthesis in Chloroplasts and Mitochondria

et al. 2006

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Arabidopsis thaliana mutants prors1-1 and -2 were identified on the basis of a decrease in effective photosystem II quantum yield. Mutations were localized to the 59-untranslated region of the nuclear gene PROLYL-tRNA SYNTHETASE1 (PRORS1), which acts in both plastids and mitochondria. In prors1-1 and -2, PRORS1 expression is reduced, along with protein synthesis in both organelles. PRORS1 null alleles (prors1-3 and -4) result in embryo sac and embryo development arrest. In mutants with the leaky prors1-1 and -2 alleles, transcription of nuclear genes for proteins involved in photosynthetic light reactions is downregulated, whereas genes for other chloroplast proteins are upregulated. Downregulation of nuclear photosynthetic genes is not associated with a marked increase in the level of reactive oxygen species in leaves and persists in the dark, suggesting that the transcriptional response is light and photooxidative stress independent. The mrpl11 and prpl11 mutants are impaired in the mitochondrial and plastid ribosomal L11 proteins, respectively. The prpl11 mrpl11 double mutant, but neither of the single mutants, resulted in strong downregulation of nuclear photosynthetic genes, like that seen in leaky mutants for PRORS1, implying that, when organellar translation is perturbed, signals derived from both types of organelles cooperate in the regulation of nuclear photosynthetic gene expression.

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Section: Introductionmentioning

confidence: 93%

Nuclear Photosynthetic Gene Expression Is Synergistically Modulated by Rates of Protein Synthesis in Chloroplasts and Mitochondria

et al. 2006

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“…It is well established that reductions in plastid translation are sensed by the nucleus via a poorly defined retrograde signaling pathway (Oelmü ller et al, 1986;Adamska, 1995;Gray et al, 1995, Yoshida et al, 1998Gray 1999, 2002;Sugimoto et al, 2004). In this pathway, reductions in chloroplast translation elicit the transmission of a signal from the plastid to the nucleus that results in altered transcription of nuclear genes, primarily those for chloroplast proteins.…”

Section: Model Of Suppression Of Var2 Variegationmentioning

confidence: 99%

Mutations in SUPPRESSOR OF VARIEGATION1, a Factor Required for Normal Chloroplast Translation, Suppress var2-Mediated Leaf Variegation in Arabidopsis

et al. 2008

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The Arabidopsis thaliana yellow variegated2 (var2) mutant is variegated due to lack of a chloroplast FtsH-like metalloprotease (FtsH2/VAR2). We have generated suppressors of var2 variegation to gain insight into factors and pathways that interact with VAR2 during chloroplast biogenesis. Here, we describe two such suppressors. Suppression of variegation in the first line, TAG-FN, was caused by disruption of the nuclear gene (SUPPRESSOR OF VARIEGATION1 [SVR1]) for a chloroplast-localized homolog of pseudouridine (C) synthase, which isomerizes uridine to C in noncoding RNAs. svr1 single mutants were epistatic to var2, and they displayed a phenotypic syndrome that included defects in chloroplast rRNA processing, reduced chloroplast translation, reduced chloroplast protein accumulation, and elevated chloroplast mRNA levels. In the second line (TAG-IE), suppression of variegation was caused by a lesion in SVR2, the gene for the ClpR1 subunit of the chloroplast ClpP/R protease. Like svr1, svr2 was epistatic to var2, and clpR1 mutants had a phenotype that resembled svr1. We propose that an impairment of chloroplast translation in TAG-FN and TAG-IE decreased the demand for VAR2 activity during chloroplast biogenesis and that this resulted in the suppression of var2 variegation. Consistent with this hypothesis, var2 variegation was repressed by chemical inhibitors of chloroplast translation. In planta mutagenesis revealed that SVR1 not only played a role in uridine isomerization but that its physical presence was necessary for proper chloroplast rRNA processing. Our data indicate that defects in chloroplast rRNA processing are a common, but not universal, molecular phenotype associated with suppression of var2 variegation.

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“…Treatment of wild-type plants with plastid translation inhibitors, such as chloramphenicol, lincomycin, erythromycin and streptomycin, also resulted in decreased expression of nuclear genes encoding photosynthesisrelated proteins Adamska 1995;Gray et al 1995;Yoshida et al 1998;Sullivan & Gray 1999). The effect of lincomycin on the accumulation of Lhcb1 and RbcS transcripts in 7-day-old tobacco seedlings is shown in figure 1.…”

Section: Inhibitors Of Plastid Gene Expression and Plastid-ribosome Dmentioning

confidence: 99%

Coordination of plastid and nuclear gene expression

Gray

Sullivan

Wang

et al. 2003

Phil. Trans. R. Soc. Lond. B

180

178

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The coordinated expression of genes distributed between the nuclear and plastid genomes is essential for the assembly of functional chloroplasts. Although the nucleus has a pre-eminent role in controlling chloroplast biogenesis, there is considerable evidence that the expression of nuclear genes encoding photosynthesis-related proteins is regulated by signals from plastids. Perturbation of several plastid-located processes, by inhibitors or in mutants, leads to decreased transcription of a set of nuclear photosynthesisrelated genes. Characterization of arabidopsis gun (genomes uncoupled) mutants, which express nuclear genes in the presence of norflurazon or lincomycin, has provided evidence for two separate signalling pathways, one involving tetrapyrrole biosynthesis intermediates and the other requiring plastid protein synthesis. In addition, perturbation of photosynthetic electron transfer produces at least two different redox signals, as part of the acclimation to altered light conditions. The recognition of multiple plastid signals requires a reconsideration of the mechanisms of regulation of transcription of nuclear genes encoding photosynthesis-related proteins.

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Regulation of Early Light-Inducible Protein Gene Expression by Blue and Red Light in Etiolated Seedlings Involves Nuclear and Plastid Factors

Cited by 53 publications

References 27 publications

Nuclear Photosynthetic Gene Expression Is Synergistically Modulated by Rates of Protein Synthesis in Chloroplasts and Mitochondria

Nuclear Photosynthetic Gene Expression Is Synergistically Modulated by Rates of Protein Synthesis in Chloroplasts and Mitochondria

Mutations in SUPPRESSOR OF VARIEGATION1, a Factor Required for Normal Chloroplast Translation, Suppress var2-Mediated Leaf Variegation in Arabidopsis

Coordination of plastid and nuclear gene expression

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