1994
DOI: 10.1007/978-3-642-78429-3_9
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Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells

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Cited by 3 publications
(2 citation statements)
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“…The majority of the remaining portion of the presumed sulfuric acid ester, in an aqueous environment of tissues, will hydrolyze back to the parent molecule, which may be reutilized for sulfo conjugation as above. In this regard, the benzylic sulfonation of BP tetraol may represent futile cycling as often observed with other sulfate conjugates (20).…”
Section: Resultsmentioning
confidence: 88%
“…The majority of the remaining portion of the presumed sulfuric acid ester, in an aqueous environment of tissues, will hydrolyze back to the parent molecule, which may be reutilized for sulfo conjugation as above. In this regard, the benzylic sulfonation of BP tetraol may represent futile cycling as often observed with other sulfate conjugates (20).…”
Section: Resultsmentioning
confidence: 88%
“…The activity of β-glucuronidase in the lumen of the ER may lead to futile cycling of Page 10 of 26 A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 10 glucuronides [67], which, however, appears to be limited since ß-glucuronidase activity is low. ER-resident β-glucuronidase may also be responsible for hydrolysis of hormone and drug glucuronides in cells, examplified by the hydrolysis of T4 glucuronide.…”
Section: Role Of Er-localized β-Glucuronidase In Glucuronide Dispositionmentioning
confidence: 99%