Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: Further mechanistic studies

Becker, Susanne; Mundandhara, Sailaja; Devlin, Robert B.; Madden, Michael C.

doi:10.1016/j.taap.2005.01.023

Cited by 288 publications

(224 citation statements)

References 39 publications

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“…Exposure of these cells to ambient PM and organic DEP chemicals can induce the generation of ROS and oxidative stress, which can result in increased cytokine and chemokine production [54,55]. Examples include increased TNF-α and IL-6 production in macrophages and IL-8 production in bronchial epithelial cells [54]. Additional evidence supporting the role of oxidative stress in PM-induced airway inflammation comes from animal studies [56][57][58].…”

Section: The Impact Of Particulate Pollutants On Asthmamentioning

confidence: 99%

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

Xia

Nel

2008

Free Radical Biology and Medicine

812

529

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Ambient particulate matter (PM) is an environmental factor that has been associated with increased respiratory morbidity and mortality. The major effect of ambient PM on the pulmonary system is the exacerbation of inflammation, especially in susceptible people. One of the mechanisms by which ambient PM exerts its proinflammatory effects is the generation of oxidative stress by its chemical compounds and metals. Cellular responses to PM-induced oxidative stress include activation of antioxidant defense, inflammation, and toxicity. The pro-inflammatory effect of PM in the lung is characterized by increased cytokine/chemokine production and adhesion molecule expression. Moreover, there is evidence that ambient PM can act as an adjuvant for allergic sensitization, which raises the possibility that long-term PM exposure may lead to increased prevalence of asthma. In addition to ambient PM, rapid expansion of nanotechnology has introduced the potential that engineered NP may also become airborne and may contribute to pulmonary diseases by novel mechanisms that could include oxidant injury. Currently, little is known about the potential adverse health effect of these particles. In this communication, the mechanisms by which particulate pollutants, including ambient PM and engineered NP, exert their adverse effects through the generation of oxidative stress and the impacts of oxidant injury in the respiratory tract will be reviewed. The importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will also be discussed.

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Section: The Impact Of Particulate Pollutants On Asthmamentioning

confidence: 99%

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

Xia

Nel

2008

Free Radical Biology and Medicine

812

529

View full text Add to dashboard Cite

show abstract

“…The parallels drawn in terms of aspect ratio and fibrous nature highlight the need for further investigations of the comparative toxicity of CNT and asbestos fibres. Cytotoxicity, pro-inflammatory and fibrogenic factors released by lung target cells are believed to play a key role in the pathogenesis of asbestos toxicity [Becker et al, 2005b;Mossman and Churg 1998;Shukla et al, 2003b]. Thus a systematic comparison of SWCNT bundles and asbestos fibres is advantageous and was therefore conducted in this study.…”

Section: Introductionmentioning

confidence: 99%

SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro

Herzog¹,

Byrne²,

Casey³

et al. 2009

Toxicology and Applied Pharmacology

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“…Physiologically, inflammation plays important roles in maintaining homeostasis including tissue repair and remodeling. 1,2) However, in chronic conditions, inflammation can lead to various diseases including inflammatory disorders, autoimmune diseases, inflammatory bowel disease, arthritis, lupus erythmatosus, endotoxin-induced organ failure, and malignancy. [3][4][5] Control of excessive inflammation has gained a continuous attention, but the currently available drugs for treating chronic inflammatory conditions produce serious side effects; therefore, finding equally effective but less toxic agents is a current challenge in scientific research.…”

mentioning

confidence: 99%

Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of <i>Dendropanax morbifera</i> Mediated by the Nrf2/HO-1 Pathway

Akram

Kim

et al. 2016

Biological & Pharmaceutical Bulletin

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Dendropanax morbifera LEVEILLE (DP) has been used in traditional Korean medicines to treat a variety of inflammatory diseases. Although the in vitro anti-inflammatory potential of this plant is understood, its in vivo efficacy and underlying molecular mechanism of anti-inflammatory effects are largely unknown. We elucidated the anti-inflammatory and analgesic activities and the underlying molecular mechanisms of DP using in vitro and in vivo models. Lipopolysaccharide (LPS)-stimulated murine macrophages were used to analyze the in vitro anti-inflammatory potential of DP extract and to elucidate the underlying mechanisms.In vivo animal models of phorbol 12-myristate 13-acetate (TPA)-induced ear edema and acetic acid-induced writhing response tests were used to analyze the in vivo anti-inflammatory effects and anti-nociceptive effects of DP extract, respectively. Methanolic extract of DP (DPME) significantly inhibited the release of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) in LPS-activated macrophages. Among the five sub-fractions, the chloroform fraction (DP-C) showed the most potent suppressive effects against pro-inflammatory mediators and cytokines in LPS-stimulated macrophages. These effects were attributed to inhibition of nuclear factor-κB (NF-κB) nuclear translocation and c-Jun N terminal kinase (JNK) 1/2 phosphorylation and to activation of NF-E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling. DP-C exhibited strong protective in vivo effects in TPA-induced ear edema mouse model and acetic acid-induced writhing response test. Our data suggest that DP-C has potent anti-inflammatory and analgesic activities and may be a promising treatment against a variety of inflammatory diseases.

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Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: Further mechanistic studies

Cited by 288 publications

References 39 publications

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro

Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of <i>Dendropanax morbifera</i> Mediated by the Nrf2/HO-1 Pathway

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