Regulation of collagen A1(I) mRNA by the 3' UTR

Lindquist, Jeff; Stefanovic, Branko; Brenner, David A.

doi:10.1016/s0016-5085(00)86100-4

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“…Type I collagen expression is also regulated post-transcriptionally at the mRNAs and translational levels. [213][214][215][216][217] In the 5 0 untranslated region (5 0 UTR) of COL1A1 and COL1A2 mRNAs, there is a well-conserved 5 0 stem-loop (5 0 SL) structure encompassing the start codon. 213,218 La ribonucleoprotein domain family member 6 (LARP6) specifically binds to type I collagen 5 0 SL and increases the stability and translational efficiency of COL1A1 and COL1A2 mRNAs.…”

Section: The Post-transcriptional Regulation Of Type I Collagen Synth...mentioning

confidence: 99%

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Targeting type I collagen for cancer treatment

Shi

Zhang

Zhu

et al. 2022

Intl Journal of Cancer

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Collagen is the most abundant protein in animals. Interactions between tumor cells and collagen influence every step of tumor development. Type I collagen is the main fibrillar collagen in the extracellular matrix and is frequently upregulated during tumorigenesis. The binding of type I collagen to its receptors on tumor cells promotes tumor cell proliferation, epithelial-mesenchymal transition and metastasis. Type I collagen also regulates the efficacy of tumor therapies, such as chemotherapy, radiotherapy and immunotherapy. Furthermore, type I collagen fragments are diagnostic markers of metastatic tumors and have prognostic value. Inhibition of type I collagen synthesis has been reported to have antitumor effects in animal models. However, collagen has also been shown to possess antitumor activity. Therefore, the roles that type I collagen plays in tumor biology are complex and tumor type-dependent. In this review, we discuss the expression and regulation of synthesis of type I collagen, as well as the role upregulated type I collagen plays in various stages of cancer Abbreviations: *OH, hydroxyl radical; 5 0 UTR, 5 0 untranslated region; 5 0 SL, 5 0 stem-loop; ABC, ATP binding cassette; AKT, v-Akt murine thymoma viral oncogene homolog; BLCA, bladder urothelial

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Section: The Post-transcriptional Regulation Of Type I Collagen Synth...mentioning

confidence: 99%

“…Type I collagen expression is also regulated post‐transcriptionally at the mRNAs and translational levels 213‐217 . In the 5′untranslated region (5′UTR) of COL1A1 and COL1A2 mRNAs, there is a well‐conserved 5′stem‐loop (5′SL) structure encompassing the start codon 213,218 .…”

Section: The Regulation Of Type I Collagen Expressionmentioning

confidence: 99%