Targeting type I collagen for cancer treatment

Shi, Run; Zhang, Zhe; Zhu, A Ying; Xiong, Xiangyang; Zhang, Jie; Xu, Jianmin; Sy, Man‐Sun; Li, Chaoyang

doi:10.1002/ijc.33985

Cited by 26 publications

(32 citation statements)

References 281 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The collagen in articular cartilage is chiefly the type II form but other types, including types I and III, have been reported. Type I collagen is abundant in the human body and is the primary constituent of skin, bone, tendon, and blood vessels [ 49 , 50 ]. Mutations in the type I collagen gene cause the Ehlers–Danlos syndrome and osteogenesis imperfecta [ 51 ].…”

Section: Extracellular Matrix In Osteoarthritismentioning

confidence: 99%

The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis

Peng

et al. 2022

Biomolecules

View full text Add to dashboard Cite

Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized by the inflammation of the bone leading to degeneration and loss of cartilage function. Factors, including diet, age, and obesity, impact and/or lead to osteoarthritis. In the past few years, OA has received considerable scholarly attention owing to its increasing prevalence, resulting in a cumbersome burden. At present, most of the interventions only relieve short-term symptoms, and some treatments and drugs can aggravate the disease in the long run. There is a pressing need to address the safety problems due to osteoarthritis. A disintegrin-like and metalloprotease domain with thrombospondin type 1 repeats (ADAMTS) metalloproteinase is a kind of secretory zinc endopeptidase, comprising 19 kinds of zinc endopeptidases. ADAMTS has been implicated in several human diseases, including OA. For example, aggrecanases, ADAMTS-4 and ADAMTS-5, participate in the cleavage of aggrecan in the extracellular matrix (ECM); ADAMTS-7 and ADAMTS-12 participate in the fission of Cartilage Oligomeric Matrix Protein (COMP) into COMP lyase, and ADAMTS-2, ADAMTS-3, and ADAMTS-14 promote the formation of collagen fibers. In this article, we principally review the role of ADAMTS metalloproteinases in osteoarthritis. From three different dimensions, we explain how ADAMTS participates in all the following aspects of osteoarthritis: ECM, cartilage degeneration, and synovial inflammation. Thus, ADAMTS may be a potential therapeutic target in osteoarthritis, and this article may render a theoretical basis for the study of new therapeutic methods for osteoarthritis.

show abstract

Section: Extracellular Matrix In Osteoarthritismentioning

confidence: 99%

The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis

Peng

et al. 2022

Biomolecules

View full text Add to dashboard Cite

show abstract

“…In the progression of PTC, deregulation of focal adhesion kinase (FAK) is observed at both post‐transcriptional and translational levels 39 . Collagen is one of the most abundantly expressed proteins in humans, and collagens are involved at every level of cancer development and establish interactions with cancer cells 40 . One of the recent studies has shown that collagen family genes (especially COL18A1 overexpression) are associated with poor prognosis and can be used as prognostic biomarkers for PTC 41 …”

Section: Discussionmentioning

confidence: 99%

Network medicine approaches for identification of novel prognostic systems biomarkers and drug candidates for papillary thyroid carcinoma

Kori,

Temiz,

Gov

2023

J Cellular Molecular Medi

View full text Add to dashboard Cite

Papillary thyroid carcinoma (PTC) is one of the most common endocrine carcinomas worldwide and the aetiology of this cancer is still not well understood. Therefore, it remains important to understand the disease mechanism and find prognostic biomarkers and/or drug candidates for PTC. Compared with approaches based on single‐gene assessment, network medicine analysis offers great promise to address this need. Accordingly, in the present study, we performed differential co‐expressed network analysis using five transcriptome datasets in patients with PTC and healthy controls. Following meta‐analysis of the transcriptome datasets, we uncovered common differentially expressed genes (DEGs) for PTC and, using these genes as proxies, found a highly clustered differentially expressed co‐expressed module: a ‘PTC‐module’. Using independent data, we demonstrated the high prognostic capacity of the PTC‐module and designated this module as a prognostic systems biomarker. In addition, using the nodes of the PTC‐module, we performed drug repurposing and text mining analyzes to identify novel drug candidates for the disease. We performed molecular docking simulations, and identified: 4‐demethoxydaunorubicin hydrochloride, AS605240, BRD‐A60245366, ER 27319 maleate, sinensetin, and TWS119 as novel drug candidates whose efficacy was also confirmed by in silico analyzes. Consequently, we have highlighted here the need for differential co‐expression analysis to gain a systems‐level understanding of a complex disease, and we provide candidate prognostic systems biomarker and novel drugs for PTC.

show abstract

“…Type I collagen is frequently upregulated during tumorigenesis. By binding to its receptors on tumor cells, Type I collagen can promote tumor cell proliferation, epithelial-mesenchymal transition and metastasis, as well as regulate the efficacy of chemotherapy, radiotherapy and immunotherapy [ 63 ]. Therefore, consistent with these reports, our findings suggest that KIAA1199 may be involved in shaping a tumor-friendly TME, thereby accelerating cancer progression and deteriorating prognosis in LUAD patients.…”

Section: Discussionmentioning

confidence: 99%

KIAA1199 Correlates With Tumor Microenvironment and Immune Infiltration in Lung Adenocarcinoma as a Potential Prognostic Biomarker

Shen¹,

Mo²,

Tan³

et al. 2022

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Background: KIAA1199 has been considered a key regulator of carcinogenesis. However, the relationship between KIAA1199 and immune infiltrates, as well as its prognostic value in lung adenocarcinoma (LUAD) remains unclear.Methods: The expression of KIAA1199 and its influence on tumor prognosis were analyzed using a series of databases, comprising TIMER, GEPIA, UALCAN, LCE, Prognoscan and Kaplan-Meier Plotter. Further, immunohistochemistry (IHC), western blot (WB) and receiver operating characteristic (ROC) curve analyses were performed to verify our findings. The cBioPortal was used to investigate the genomic alterations of KIAA1199. Prediction of candidate microRNA (miRNAs) and transcription factor (TF) targeting KIAA1199, as well as GO and KEGG analyses, were performed based on LinkedOmics. TIMER and TISIDB databases were used to explore the relationship between KIAA1199 and tumor immune infiltration.Results: High expression of KIAA1199 was identified in LUAD and Lung squamous cell carcinoma (LUSC) patients. High expression of KIAA1199 indicated a worse prognosis in LUAD patients. The results of IHC and WB analyses showed that the expression level of KIAA1199 in tumor tissues was higher than that in adjacent tissues. GO and KEGG analyses indicated KIAA1199 was mainly involved in extracellular matrix (ECM)-receptor interaction and extracellular matrix structure constituent. KIAA1199 was positively correlated with infiltrating levels of CD4+ T cells, macrophages, neutrophil cells, dendritic cells, and showed positive relationship with immune marker subsets expression of a variety of immunosuppressive cells.Conclusion: High expression of KIAA1199 predicts a poor prognosis of LUAD patients. KIAA1199 might exert its carcinogenic role in the tumor microenvironment via participating in the extracellular matrix formation and regulating the infiltration of immune cells in LUAD. The results indicate that KIAA1199 might be a novel biomarker for evaluating prognosis and immune cell infiltration in LUAD.

show abstract

Targeting type I collagen for cancer treatment

Cited by 26 publications

References 281 publications

The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis

The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis

Network medicine approaches for identification of novel prognostic systems biomarkers and drug candidates for papillary thyroid carcinoma

KIAA1199 Correlates With Tumor Microenvironment and Immune Infiltration in Lung Adenocarcinoma as a Potential Prognostic Biomarker

Contact Info

Product

Resources

About