REGULATION OF cIAP1 AND XIAP EXPRESSION BY NITRIC OXIDE, CYTOKINES, AND ITS RELATION TO APOTOSIS INDUCTION IN RAT MESANGIAL CELLS AND RAW 264.7 MACROPHAGES

Human RPE Expression of Cell Survival Factors

“…Alternatively, survival factor protein production may be regulated by post transcriptional mechanisms, as has been reported previously. [41][42][43] In the present report, we found that cultured RPE cells produce TRAF-1 and -2 and c-IAP1 and -2 proteins. To our .…”

Effect of barley β-glucan on murine RAW264.7 macrophages against virulent Salmonella enterica serovar Typhimurium

“…Two isoforms of dectin-1 mRNA were 600 bases and 500 bases in size, respectively. apoptosis and leading to salmonellosis (Brennan & Cookson, 2000;Manderscheid, Meβmer, Franzen, & Pfeilschifter, 2001).…”

Nitric Oxide and the Regulation of Apoptosis in Tumour Cells

“…In the apoptotic pathway, NO can lead to increased expression of wild type p53 [133] and caspases 1 and 3 [290]. NO can also cause decreased expression of inhibitor of apoptosis (IAP) [240], whilst leaving the expression of Fas unchanged [309]. Modulation of these apoptotic regulatory proteins can lead to death of the tumour cells.…”

“…The members of the IAP family of proteins are the only endogenous inhibitors of caspases [239]. IAP expression has been investigated in various cell types including in mesangial cells and macrophages in relation to apoptosis induction in response to NO and cytokines [240]. Manderscheid and coworkers using NO donors and iNOS inhibitors demonstrated that in lipopolysaccharide/interferon-γ-stimulated macrophages, massive NO-dependent down regulation of cIAP1 and XIAP protein levels occurred.…”

“…Myocardial cells, hepatocytes, brain lysate Anti [104,106,[121][122][123]180] Stimulates production of heat shock proteins Hepatocytes Anti [107] Increases production of tumour suppressor gene p53 Human cancer cell lines, murine fibroblasts, macrophages Anti [133][134][135]219] Increases expression of pro-apoptotic proteins Bax and Bid Macrophages, mesangial cells, neurons Pro [136,138] Prevents the decrease in expression of anti-apoptotic protein Bcl-2 B lymphocytes, neurons Anti [137,138,243,244] Binds to cytochrome c oxidase and prevents mitochondrial respiration Murine monocyte line Pro [158,[173][174][175][176][177] Activation of mitochondrial permeability transition Thymocytes Pro [308] Causes degradation of the mitochondrial phospholipid cardiolipin Jurkat T lymphocytes Pro [166] Inhibits the expression of inhibitor of apoptosis protein (IAP) Lung carcinoma cells Pro [228] Activation of the MAP kinase JNK Neuroblastoma cells Pro [230,231] Activation of the MAP kinase ERK Breast cancer cell lines Anti [232] Increased acivity of the DNA repair enzyme DNA-PK Cancer cell lines Anti [234] Downregulates IAP proteins Macrophages Pro [240] Enhances expression of genes encoding detoxifying enzymes and other anti-apoptotic proteins Neuroblastoma cells Anti [250] Induces lysis of cells Mastocytoma cells, fibroblast tumour cells Pro [220] Activation of matrix metalloproteinases Articular cartilage Pro [284] Blocks JNK activation Liver epithelial cells Anti [110,…”