Regulation of Blood Glucose, Insulin and Diabetes Mellitus

Vasudevan, DM; Sreekumari, S; Vaidyanathan, Kannan

doi:10.5005/jp/books/13014_12

Cited by 2 publications

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“…Type 1 diabetes (or Insulin Dependent Diabetes Mellitus (IDDM)) accounted for around 10% of all diabetes cases and rottenly occurs in individuals under age of 40 years. In this type a normal lack of insulin release occurs which causes damaging of the β-cells in pancreas (Vasudevan & Sreekumari, 2011). Alternatively, type 2 diabetes effects about 90% of persons that are at or more 40 years old.…”

Section: Diabetes Is Basically Related With Hazardous Difficulties Inmentioning

confidence: 99%

“…Alternatively, type 2 diabetes effects about 90% of persons that are at or more 40 years old. In this type, insensitivity of tissues to insulin stimulating weakened insulin activity and sometimes, high levels of insulin (Vasudevan & Sreekumari, 2011). Enzymes, such as, α-amylase and α-glucosidase in humans body act in harmony to hydrolyze starch by pancreatic α-amylase and to absorb glucose by intestinal α-glucosidase which may swift postprandial hyperglycemia (Unnikrishnan et al, 2015).…”

Section: Diabetes Is Basically Related With Hazardous Difficulties Inmentioning

confidence: 99%

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In vitro potential activity of some seaweeds as antioxidants and inhibitors of diabetic enzymes

et al. 2020

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In this study crude extracts of Turbinaria decurrens, Padina pavonica, Sargassum muticum and Sargassum acinarium (Phaeophyta); Ulva lactuca (Chlorophyta) and Pterocladia capillacea (Rhodophyta) seaweeds were tested to evaluate their antioxidant properties and antidiabetic potential on α-amylase and α-glucosidase starch hydrolyzing enzymes. The results showed that all analyzed seaweeds exhibited antioxidant effects using DPPH (2,2-Diphenyl-1-picrylhydrazyl), reducing power and total antioxidant capacity assays in addition to antidiabetic activity that all depended on the species and the extract solvent. Among the tested extracts, acetone extract of Turbinaria decurrens showed the highest antioxidant activity and inhibitory effects for α-amylase (96.1%) and α-glucosidase (97.4%), respectively which was related with its total phenolic content and antioxidant activity. In vitro, the extract showed no toxicity against fibroblast normal cell lines at lower concentration of 250 µg/ml. Gas Chromatography-Mass Spectrum analysis (GC-MS) of this acetone extract showed the presence of different bioactive compounds mainly cyclotrisiloxane, hexamethyl which could be responsible for its antioxidant and antidiabetic activities. The study results suggest that brown seaweeds especially T. decurrens can be used as antioxidant ingredients and as potent reducing drug for postprandial hyperglycemia.

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Section: Diabetes Is Basically Related With Hazardous Difficulties Inmentioning

confidence: 99%

Section: Diabetes Is Basically Related With Hazardous Difficulties Inmentioning

confidence: 99%

In vitro potential activity of some seaweeds as antioxidants and inhibitors of diabetic enzymes

et al. 2020

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“…Diabetes, cardiovascular disease, and fatty liver come from glucose and lipid metabolism problems [1]. blood glucose levels in humans are tightly controlled mostly by pancreatic hormones such as insulin and glucagon, but also by growth hormones, epinephrine, cortisol, and other glucocorticoids are important [2,3]. Diabetes mellitus (DM) is a metabolic condition defined by the elevated blood sugar brought on by aberrant insulin production or insulin malfunction [4].…”

Section: Introductionmentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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Adipose tissue secretes the hormone asprosin. The asprosin molecule has several roles in the central nervous system and other body systems: hunger, glucose metabolism, insulin resistance (IR), and cellular death. IR is pathologically associated with high asprosin levels. Patients with type 2 diabetes mellitus (DMІІ) are more likely to have thyroid problems. Over time, many diabetics develop thyroid dysfunctional symptoms. The study included 80 women. Forty had hypothyroidism with diabetes (DMII), and 40 were healthy controls. Gathered samples from the National Diabetes Center,

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Regulation of Blood Glucose, Insulin and Diabetes Mellitus

Cited by 2 publications

References 0 publications

In vitro potential activity of some seaweeds as antioxidants and inhibitors of diabetic enzymes

In vitro potential activity of some seaweeds as antioxidants and inhibitors of diabetic enzymes

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