Regulation of Aquaporins and Sodium Transporter Proteins in the Solitary Kidney in Response to Partial Ureteral Obstruction in Neonatal Rats

Topçu, Şükrü Oğuzkan; Nørregaard, Rikke; Pedersen, Michael; Wang, Guixian; Jørgensen, Troels Munch; Frøkiær, Jørgen

doi:10.1159/000319969

Cited by 8 publications

(5 citation statements)

References 56 publications

(50 reference statements)

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“…It seems that the protective role of estradiol in renal system was not certain. Previously, it is reported that UUO is accompanied with increasing of serum BUN and Cr levels (10), reduction of GFR about 20-70% (11,12), decreasing of tubular injury and interstitial fibrosis (13), reduction of UNaV and urine osmolality (14), and increasing of fibronectin expression (15). In our study, the serum level of BUN and Cr were increased by UUO possibly by renal fibrosis or GFR reduction.…”

Section: Discussionsupporting

confidence: 64%

The Effect of Estradiol on Renal Function in Reversible and Irreversible Unilateral Ureteral Obstruction in Rats

2018

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BACKGROUND: The ureteral obstruction (UO) is the most common clinical disorders. This study was designed to investigate the renoprotective effect of estradiol in unilateral UO (UUO) and reversible UUO (RUUO).METHODS: Eighty-four ovareictomized Wistar rats were assigned into 14 groups. Group 1 was sham operated group. All the groups 2-14 were subject to UUO, however they received additional treatments. Group 2-4 received test substances (vehicle, 0.1 or 0.05 mg/kg of estradiol) and sacrificed after 3 days. Group 5-7 received test substances and after 3 days followed by RUUO (obstruction removal) and after one day post RUUO were sacrificed. Group 8-9 followed by RUUO after 3 days and simultaneously received estradiol and after one day post RUUO were sacrificed. Group 10-12 followed by RUUO after 3 days and simultaneously received test substances and after 3 days post RUUO were sacrificed. Group 13-14 received test substances followed by RUUO and received test substances again and after 3 days post RUUO were sacrificed.RESULTS: The estradiol reduced body weight significantly (p<0.05) in UUO, and the uterus weight (UW) increased significantly by estradiol (p<0.05). The increased serum levels of blood urea nitrogen (BUN) and creatinine (Cr), and kidney weight (KW) induced by UUO (p<0.05) were not attenuated by estradiol. Estradiol treatment did not alter the levels of BUN, Cr, KW, Cr clearance (CrCl), urine sodium excretion and urine flow when compared with control.CONCLUSION: Although the protective role of estradiol in cardiovascular system is well accepted, however our findings suggest that its protection during UUO or after RUUO in renal system cannot be certain.KEYWORDS: estradiol, ureteral obstruction, renal function, rat

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Section: Discussionsupporting

confidence: 64%

The Effect of Estradiol on Renal Function in Reversible and Irreversible Unilateral Ureteral Obstruction in Rats

2018

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“…A similar phenomenon was observed in both BUO and UUO [8,9]. A study with partial ureteral obstruction also showed a decrease in AQP 1 [10].…”

Section: Pathogenesissupporting

confidence: 73%

Nephrogenic Diabetes Insipidus Due to Urinary Tract Obstruction: A Systematic Review

Qizalbash

Zahra²,

Kumar

et al. 2017

IMMINV

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Background: Nephrogenic diabetes insipidus (NDI) due to obstructive uropathy is not widely known by physicians and hence not well represented in the literature. To better understand its presentation, clinical course, and available treatments, we conducted a systematic review of case reports on NDI due to urinary tract obstruction. Material and Methods: This observational study was a systematic review of 19 human cases found in the literature. It was done retrospectively to focus on whether NDI can occur due to obstruction of the urinary tract and, if so, what the mechanism (pathophysiology) is. Results: We found that the most common symptom of NDI due to urinary tract obstruction was polyuria. The most common cause of NDI due to urinary tract obstruction was cancer. The most common site for obstruction was the ureter. And the most common test used to confirm the diagnosis was failure to concentrate urine after the administration of desmopressin. Surgical intervention was the most common treatment to relieve obstruction. Conclusion: We found that urinary tract obstruction can cause NDI. With early diagnosis and timely relief of the obstruction, NDI can be reversible.

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“…reported that GFR, urine osmolality, and urinary sodium excretion were reduced in solitary kidney with UUPJO. [20] In rodent models, both partial and complete obstruction resulted in alteration in urinary osmolytes. [21] While acute short-term unilateral obstruction in rats has not changed the permeability to water and reabsorptive capacity of terminal collecting duct, prolonged unilateral obstruction has resulted in increased cyclooxygenase and decreased permeability to water and urinary sodium excretion in obstructed kidney.…”

Section: Discussionmentioning

confidence: 99%

Glomerular filtration rate and urine osmolality in unilateral ureteropelvic junction obstruction

Gheissari

Nematbakhsh²,

Amir-Shahkarami³

et al. 2013

Adv Biomed Res

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Background:Renal maldevelopment, interstitial fibrosis, ischemic atrophy, decreased glomerular filtration rate (GFR), and renal blood flow (RBF) are inevitable consequences of chronic kidney obstruction that only partially improve after early intervention. There are only few studies that evaluated urine osmolality in affected kidney and its correlation with short-term outcome.Materials and Methods:Thirty patients (age<1 year) with unilateral ureteropelvic junction obstruction (UUPJO) were enrolled in this study. UUPJO was confirmed using Technetium 99 isotope scans and the patients were indicated to be operated afterward. Urine and blood samples were obtained before, 24, 48, and 72 h after the surgery. The serum level of blood urea nitrogen, creatinine, and glucose were measured. GFR, urine osmolality (measured and calculated), and urine specific gravity were determined too.Results:Cortical thickness of hydronephrotic kidney was significantly increased 6 months after the surgery. GFR was significantly increased 72-h postsurgery compared to before operation.Neither means of calculated nor of measured urine osmolalities were significantly different in various stages. The last calculated urine osmolality (72 h) had significant correlation with the last measured osmolality (72 h); r=0.962, P=0.0001. The last GFR (72 h) had positive significant correlation with GFR before the surgery and GFRs at 24 and 48 h postsurgery.Using regression tests, only the before surgery GFR was the predictor of the last GFR(72 h).Conclusion:In UUPJO the measured and calculated urine osmolality of the affected kidney did not differ. In addition, GFR before surgery should be considered as the predictor of the GFR shortly after repair.

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Regulation of Aquaporins and Sodium Transporter Proteins in the Solitary Kidney in Response to Partial Ureteral Obstruction in Neonatal Rats

Cited by 8 publications

References 56 publications

The Effect of Estradiol on Renal Function in Reversible and Irreversible Unilateral Ureteral Obstruction in Rats

The Effect of Estradiol on Renal Function in Reversible and Irreversible Unilateral Ureteral Obstruction in Rats

Nephrogenic Diabetes Insipidus Due to Urinary Tract Obstruction: A Systematic Review

Glomerular filtration rate and urine osmolality in unilateral ureteropelvic junction obstruction

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