Regulation of apo B mRNA expression in liver and intestine during liver regeneration induced by CCl4

Maldonado, Vilma; Chan, Lawrence; Melendez, J.Andres; Rincón, Ana Rosa; Zhu, Hengyue; Panduro, Arturo

doi:10.1016/0005-2760(94)90131-7

Cited by 12 publications

(1 citation statement)

References 32 publications

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“…It is well known that the liver has powerful regenerative capacity and usually can restore metabolic requirement rapidly after injury (Morrison et al, 1965;Popper, 1979;Karp, 2009). Once the regenerative process has occurred both lipoproteins increase to values higher than control in CCl 4 -treated rats (Maldonado et al, 1994) which were accompanied by a fatty change in acute liver damage in this study. The signs of high regenerative activity as revealed by binucleate cells and a mitotic figure reflected liver injury and increased cell death.…”

Section: Discussionsupporting

confidence: 50%

Hepatoprotective effects of lychee (Litchi chinensis Sonn.): A combination of antioxidant and anti-apoptotic activities

Bhoopat

Srichairatanakool

Kanjanapothi

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 50%

Hepatoprotective effects of lychee (Litchi chinensis Sonn.): A combination of antioxidant and anti-apoptotic activities

Bhoopat

Srichairatanakool

Kanjanapothi

et al. 2011

Journal of Ethnopharmacology

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Probing the genome for new drugs and targets with DNA arrays

Lillie

1997

Drug Dev. Res.

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Editing our way to regeneration

Morrison

2014

Cell Tissue Res

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Transcription is the primary regulatory step to gene expression. However, there are numerous post-transcriptional mechanisms that are also crucial for developing the transcritptome, and the subsequent proteome, signature of any physiological setting. Organ and tissue regeneration is one such physiological setting that requires the rapid development of an environment that can supply all of the necessary molecular and cellular signalling needs necessary to attenuate infection, remove dead or necrotic cells, provide structural stability and finally replenish the compromised area with functional cells. The post-transcriptional regulatory mechanisms that have the ability to heavily influence the molecular and cellular pathways associated with regeneration are slowly being characterized. This mini-review will further clarify the possible regulation of regeneration through adenosine-to-inosine (A-I) RNA editing; a post-transcriptional mechanism that can affect the molecular and cellular pathways associated with functional restoration of damaged tissues and organs through discrete nucleotide changes in RNA transcripts. It is hoped that the intriguing links made between A-I RNA editing and regeneration in this mini-review will encourage further comparative studies into this infant field of research.

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Regulation of apo B mRNA expression in liver and intestine during liver regeneration induced by CCl4

Cited by 12 publications

References 32 publications

Hepatoprotective effects of lychee (Litchi chinensis Sonn.): A combination of antioxidant and anti-apoptotic activities

Hepatoprotective effects of lychee (Litchi chinensis Sonn.): A combination of antioxidant and anti-apoptotic activities

Probing the genome for new drugs and targets with DNA arrays

Editing our way to regeneration

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