Regulation of adiponectin on lipid metabolism in large yellow croaker (Larimichthys crocea)

Ji, Renlei; Xu, Xiang; Xiang, Xiaojun; Zhu, Si; Li, Yongnan; Mai, Kangsen; Ai, Qinghui

doi:10.1016/j.bbalip.2020.158711

Cited by 15 publications

(50 citation statements)

References 59 publications

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“…20 Then, adiponectin was identified in ayu (Plecoglossus altivelis) and, more recently, in large yellow croaker (Larimichthys crocea). 21,27 In addition, several fish adiponectin gene sequences can also be found in the NCBI database (www.ncbi.nlm.nih.gov), such as Atlantic salmon (Salmo salar, XM_014159439), coho salmon (Oncorhynchus kisutch, XM_020466425), Asian bonytongue (Scleropages formosus, XM_018740994), coelacanth (Latimeria chalumnae, XM_005991168), spotted gar (Lepisosteus oculatus, XM_006637785), Atlantic herring (Clupea harengus, XM_012821260), golden-line barbel (Sinocyclocheilus graham, XM_016252241) and common carp (Cyprinus carpio, XM_019083697 and XM_019106129). Though these are only predicted sequences from the genome, interestingly, all of these adiponectin genes are clusters with only one type of adiponectin in zebrafish.…”

Section: Teleostean Adiponectinmentioning

confidence: 99%

“…Since the first identification of adiponectin and its receptors in a teleost (zebrafish, Danio rerio), 17 more adiponectin and related receptors have been identified and reported among different fish species (Table 1). [18][19][20][21][22][23][24][25][26][27] In teleosts, adiponectin has been confirmed to play a crucial role in energy homeostasis and antiinflammation. For example, reduced plasma adiponectin concentrations were observed in zebrafish fed high-fat diet (HFD), and this reported hypoadiponectinemia has been suggested to be related to abnormal hepatic lipid deposition and low disease resistance in captive fish.…”

Section: Introductionmentioning

confidence: 99%

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Adiponectin’s roles in lipid and glucose metabolism modulation in fish: Mechanisms and perspectives

Turchini

et al. 2021

Reviews in Aquaculture

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Glucose and lipid metabolisms are central in determining the growth and the health status of cultured fish and thus are of pivotal interest for modern aquaculture.Adiponectin is a fat-derived hormone that plays a vital role in glucose and lipid homeostasis. While abundant knowledge is available on adiponectin in mammals, less is known in fish, though it has been documented that adiponectin is certainly important in the modulation of teleosts' lipid and glucose metabolism too. Adiponectin exerts its metabolic effects via two receptors, AdipoR1 and AdipoR2, which then, in a tissuedependent manner, initiate a series of signal transduction events, eventually resulting in increased glucose utilization and fatty acid β-oxidation. In teleosts, adiponectin and its receptors genes were first identified in zebrafish in 2008, and since then, increasing numbers of adiponectin and its receptors have been cloned in a variety of cultured fish species. This review attempts to provide the first, thorough overview of the discovery and identification of adiponectin, its receptors and their expression, regulation and signal transduction in fish. Then, the potential effects and mechanisms of adiponectin on energy (lipid and glucose) homeostasis are described, before concluding on possible therapeutic approaches to enhance adiponectin actions. It is envisaged that the present work will contribute, first, to knowledge gain in the evolution of energy homeostasis in vertebrates, and then, to provide a much-needed additional theoretical fundament for a healthier and further performance-improved aquaculture.

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Section: Teleostean Adiponectinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adiponectin’s roles in lipid and glucose metabolism modulation in fish: Mechanisms and perspectives

Turchini

et al. 2021

Reviews in Aquaculture

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“…Accepted manuscript an important economical marine fish due to its delicious taste and high nutritional value (25) . Furthermore, lipid metabolisms among the large yellow croaker, other fish and mammals are similar, and large yellow croaker could be considered as an appropriate model for regulation of lipid metabolism in marine fish (3,(26)(27)(28) . Thus, this study was to investigate the protective effects of curcumin against hepatic steatosis.…”

Section: Large Yellow Croaker (Larimichthys Crocea) Widely Cultured mentioning

confidence: 99%

“…The amplification was performed in a total volume of 25 μl, containing 1 μl of each primer (10 μmol), 1 μl cDNA product, 12•5 μl SYBR-Premix ExTaqII (Takara) and 9•5 μl RNA-free water. The real-time PCR programme was as follows: 95°C for 2 min, followed by forty cycles of 95°C for 10 s, 58°C for 10 s and 72°C for 20 s. The primer sequences were obtained from previous paper (3,26,28,35) (online Supplementary Table S2). The amplification efficiencies of all genes were approximately equal and ranged from 94 to 105 %.…”

Section: Quantitative Real-time Pcrmentioning

confidence: 99%

Effects of dietary curcumin on growth, antioxidant capacity, fatty acid composition and expression of lipid metabolism-related genes of large yellow croaker fed a high-fat diet

Xiang

et al. 2020

Br J Nutr

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A 10-weeks feeding trial was conducted to investigate effects of dietary curcumin on growth, antioxidant responses, fatty acid composition, and expression of lipid metabolism-related genes of large yellow croaker fed high-fat diet. Four diets (lipid level at 18%) were formulated with different levels of curcumin (0%, 0.02%, 0.04% and 0.06%). Results showed that the best growth performance was found in 0.04% curcumin group, with the body and hepatic lipid levels lower than the control group (0% curcumin). The content of triglycerides, total cholesterol and low-density lipoprotein-cholesterol was the least in 0.06% curcumin group. The lowest malondialdehyde and the highest superoxide dismutase, catalase activity and total antioxidant capacity were observed in 0.04% curcumin group. In 0.04% curcumin group, expression of fatty acyl desaturase 6, elongases very long-chain fatty acids 5, and elongases very long-chain fatty acids 4 was upregulated in liver; moreover, the ratio of hepatic n-6 polyunsaturated fatty acid (PUFA) and n-3 PUFA was higher. Expression of peroxisome proliferators-activated receptor α, carnitine palmitoyltransferase I, and acyl-CoA oxidase was significantly increased, while expression of sterol-regulatory element-binding protein 1 and fatty acid synthase was dramatically decreased in curcumin groups compared with the control group. Overall, 0.04% curcumin supplementation could mitigate the negative effects caused by high-fat diet, and promote growth via reducing hepatic lipid deposition, improving antioxidant activity and increasing PUFA of large yellow croaker. Therefore, it is deduced that reduced abnormal hepatic lipid deposition was probably due to increased fatty acid oxidation and reduced de novo synthesis of fatty acids.

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“…Previous studies have shown that large yellow croakers fed with HFD could cause excessive fat deposition in liver [ 20 , 21 ]. Thus, the large yellow croaker is an appropriate model to investigate excessive fat deposition [ 22 , 23 , 24 ]. However, it is not clear whether the excessive fat deposition caused by high fat is related to ACC.…”

Section: Introductionmentioning

confidence: 99%

High Fat Activates O-GlcNAcylation and Affects AMPK/ACC Pathway to Regulate Lipid Metabolism

Pang

Xiang

et al. 2021

Nutrients

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A high-fat diet often leads to excessive fat deposition and adversely affects the organism. However, the mechanism of liver fat deposition induced by high fat is still unclear. Therefore, this study aimed at acetyl-CoA carboxylase (ACC) to explore the mechanism of excessive liver deposition induced by high fat. In the present study, the ORF of ACC1 and ACC2 were cloned and characterized. Meanwhile, the mRNA and protein of ACC1 and ACC2 were increased in liver fed with a high-fat diet (HFD) or in hepatocytes incubated with oleic acid (OA). The phosphorylation of ACC was also decreased in hepatocytes incubated with OA. Moreover, AICAR dramatically improved the phosphorylation of ACC, and OA significantly inhibited the phosphorylation of the AMPK/ACC pathway. Further experiments showed that OA increased global O-GlcNAcylation and agonist of O-GlcNAcylation significantly inhibited the phosphorylation of AMPK and ACC. Importantly, the disorder of lipid metabolism caused by HFD or OA could be rescued by treating CP-640186, the dual inhibitor of ACC1 and ACC2. These observations suggested that high fat may activate O-GlcNAcylation and affect the AMPK/ACC pathway to regulate lipid synthesis, and also emphasized the importance of the role of ACC in lipid homeostasis.

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Regulation of adiponectin on lipid metabolism in large yellow croaker (Larimichthys crocea)

Cited by 15 publications

References 59 publications

Adiponectin’s roles in lipid and glucose metabolism modulation in fish: Mechanisms and perspectives

Adiponectin’s roles in lipid and glucose metabolism modulation in fish: Mechanisms and perspectives

Effects of dietary curcumin on growth, antioxidant capacity, fatty acid composition and expression of lipid metabolism-related genes of large yellow croaker fed a high-fat diet

High Fat Activates O-GlcNAcylation and Affects AMPK/ACC Pathway to Regulate Lipid Metabolism

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