In these current times, scientifi c and technological progress is a global phenomenon. Theoretical discoveries in the fi elds of medicine, life sciences, neurosciences, cognitive science, and practical applications derived from them constitute two interconnected and complementary dimensions that create a rich and complex scenery. Furthermore, a trend of interaction and convergence between different sciences and technologies is visible. A meaningful example of this is represented by 'nanoscience' and 'nanotechnologies' that -like the other emerging technologiesdemonstrate numerous benefi cial applications, thus entailing potential benefi ts, but at the same time pose certain risks and concerns. This paper focuses on some of the risks that have arisen in the context of nanotechnologies, in order to look for and articulate a model of governance for dealing with these risks. For achieving this aim, a methodology founded on the comparison with another 'converging science'-the so-called synthetic biology (henceforth 'synbio')-has been chosen.From the structural viewpoint, the proposed analysis will be developed as follows: (a) a framework of similarities and differences between synbio and nanotechnology is offered; (b) an examination of the risks and the approaches required to deal with them is given, by means of a critical study of the different models of governance, and (c) this analysis proposes to fi nd, in the end, the most suitable and proper solution to apply in the area.As a premise, it should be noted that the focus of this paper is on health, safety and security issues. The social, political, economic and more intrinsically ethical topics, which are commonly associated with nanotechnologies and synbio, will not