Regulating effect of sympathetic-adrenal system on hemopoiesis suppressed by cytostatic drugs

Дыгай, А. М.; Хлусов, И. А.; Удут, В. В.; Naumov, Sergey; Gol'dberg, E. D.

doi:10.1016/s0928-4680(97)00023-0

Cited by 7 publications

(8 citation statements)

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“…CFU-E and CFU-GM are more sensitive to β-adrenergic and α-adrenergic infl uences, respectively. The role of autonomic ganglia and peripheral adrenergic structures in adaptive reactions of the blood system was confi rmed in further experiments on the models of neuroses (confl ict situation and paradoxical sleep deprivation) and myelosuppressions (cytostatic treatment in various doses) [11,16,46,62,68]. Our results illustrate general biological type of these processes.…”

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confidence: 71%

Monoaminergic Regulation of Hemopoiesis under Extreme Conditions

Дыгай¹,

Скурихин²

2011

Bull Exp Biol Med

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The role of the adrenergic, dopaminergic, and serotoninergic systems in the regulation of hemopoiesis was evaluated on various models of pathological processes (restraint stress, experimental neurosis, and cytostatic treatment). The proliferation, differentiation, and maturation of polypotent, multipotent, partially determined, and oligopotent hemopoietic precursors and functional activity of microenvironmental cells (stromal cells, macrophages, and Thy1,2(+) cells) were shown to be under the control of a complex system of monoaminergic regulation. Central monoamines have a direct or indirect (mediated by microenvironmental cells) regulatory effect on hemopoietic precursors of various classes, which is realized via specific receptors. The system of colony-stimulating factors is characterized by selective sensitivity to catecholamines. It should be emphasized that the effects of erythropoietin are mainly associated with serotonin. Irrespective of experimental conditions (hyperplasia of hemopoiesis, myelosuppression, and dysregulation of precursor cell proliferation and differentiation), the erythroid hemopoietic stem is more sensitive to serotoninergic influences. Granulocytopoiesis was revealed to be more sensitive to central catecholamines.

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confidence: 71%

Monoaminergic Regulation of Hemopoiesis under Extreme Conditions

Дыгай¹,

Скурихин²

2011

Bull Exp Biol Med

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“…Активация гипофизарно-адреналовой [56] и симпатоадреналовой систем [12] приводит к развитию феномена гиперплазии кроветворной ткани костного мозга (преимущественно за счет стимуляции процессов эритро-и грануломоноцитопоэза) и увеличению клеточности периферической крови. В основе активации гемопоэза при этом лежит усиление миграции Т-лимфоцитоврегуляторов в костный мозг [45] под действием глюкокортикоидов и катехоламинов [16,81]. К настоящему времени достаточно хорошо изучен фенотип Т-клеток, контролирующих процессы кроветворения, ряд их свойств [10,30,31,32,40,52,85].…”

Section: теория регуляции кроветворенияunclassified

Hematosis regulation theory

Дыгай

2004

Bûll. sib. med.

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It has been revealed that blood system changes observed under the impact of pathogenic factors, different by their nature, and mechanisms laying in their basis were, in many respects, of the same kind. However the specific blood system response is defined by the nature of the acting exciter owing to specific changes in regulation structure functioning. Therefore changes in white blood, and at the acute hemorrhage – in red blood, prevail at inflammation during stress along with the proportional stimulation of different medullary hematosis outgrowths. Repeated extreme impacts lead to the emaciation of adaptive abilities of hemopoietic tissue as a result of the expressed hemopoiesis rocess irregulation.

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“…Treatment with the alkylating agent cyclophosphamide also led to rapid recovery of structural and functional organization of the bone marrow and early stimulation of secretory activity of adherent myelokaryocytes in cooperation with T cells [7,12,5311, which accelerated differentiation of granulocyte-macrophage precursors [52]. These processes sharply increased the content of neutrophil granulocytes in the bone marrow [72,97]. The long-term depression of erythrokaryocytes can be explained by pronounced damaging effect of the alkylating agent on committed hemopoietic precursors of the erythroid lineage (Fig.…”

mentioning

confidence: 99%

“…Long-term suppression of granulocyte and erythroid hemopoietic stems after treatment with the antimetabolite 5-fluorouracil [73,97] is accompanied by accumulation of hemopoietic precursors in the hemopoietic tissue [27] due to their disturbed maluration [52]. This phenomenon can be explained by active proliferation of hemopoietic precursors against the background of disturbed (due to crude dissociation of precursors and stromal elements of HIM) structural and functional organization of the bone marrow [27,73].…”

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confidence: 99%

“…This impairs cooperation of HIM cell in the regulation of proliferation and differentiation of stem cells [65] and determines long-term regeneration dynamics typical of 5-fluorouracil [85]. The same vector of regulatory (suppressive/stimulating) effects of catecholamines is observed after treatment with high doses of cyclophosphamide to tumor-bearing or healthy experiment'al animals [27,97]. Other stress-realizing hormones glucocorticoids produce similar modulating effects on hemopoiesis under conditions of cytostatic treatment.…”

mentioning

confidence: 99%

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