Regulating Drug Release Via Non-Uniform Distribution of Coating Composition in Multilayer Drug-Coated Granules

Wan, Lucy S.C.; Lai, W.F.

doi:10.3109/03639049409042661

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…The gradient principle offers great flexibility in regulating the delivery of drugs and is consequently suitable for many types of system 7, 8. The entrapment of drugs in deep layers of the scaffolds compensates for the traveling distance of the drugs during the dissolution process, thus resulting in the desirable production of a linear, zero‐order pattern of drug release 9, 10.…”

Section: Introductionmentioning

confidence: 99%

Functionally gradient chitosan/hydroxyapatite composite scaffolds for controlled drug release

et al. 2008

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This study explored the potential of chitosan/hydroxyapatite (HA) composites to act as a controlled drug delivery system by developing functional scaffolds with a gradient of structure and drug concentration. Firstly, a porous composite scaffold was prepared and tetracycline hydrochloride (TCH) was impregnated in the scaffold as a model drug. The pore size of the scaffold was negatively dependent on the HA content and ranged about 40-250 lm. Subsequently, a porous chitosan/HA composite layer without drug was coated on the scaffold to create a gradient drug concentration in the specimen. The in vitro drug-release test demonstrated that the porous layer without drug on the outer surface of the scaffold significantly reduced the initial burst of drug release and extended the release period. Finally, a successive and dense chitosan/HA composite layer endowed the scaffold with a sustained, drugrelease pattern without any initial drug burst. These findings confirmed the high effectiveness of the hybrid scaffolds in regulating the release of drugs, and hence their capability to serve as a temporary drug carrier in tissue regeneration. These functional scaffolds also have potential application to the delivery of some bioactive molecules such as growth factors. '

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Section: Introductionmentioning

confidence: 99%

Functionally gradient chitosan/hydroxyapatite composite scaffolds for controlled drug release

et al. 2008

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“…Multilayered granules with non-uniform distribution of the drug were prepared by Wan and Lai using a fluidized bed coating process [73]. Specifically, three layers were applied onto 600-710 µm lactose granules varying in each layer the drug/polymer concentration and the polymer grade, as represented schematically in Fig.…”

Section: Multilayered Drug-coated Granulesmentioning

confidence: 99%

“…9. Schematic representation of systems having different patterns of drug (solid line) and polymer (dashed line) concentration drawn using data from[73] (a), and resulting release profiles (b). Redrawn from[73].…”

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confidence: 99%

Oral hydrophilic matrices having non uniform drug distribution for zero-order release: A literature review

Cerea

Maroni

Palugan

et al. 2020

Journal of Controlled Release

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Selection of optimum composition and study of specific activity of the pediatric medication form of dimedrol

et al. 1998

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Regulating Drug Release Via Non-Uniform Distribution of Coating Composition in Multilayer Drug-Coated Granules

Cited by 5 publications

References 11 publications

Functionally gradient chitosan/hydroxyapatite composite scaffolds for controlled drug release

Functionally gradient chitosan/hydroxyapatite composite scaffolds for controlled drug release

Oral hydrophilic matrices having non uniform drug distribution for zero-order release: A literature review

Selection of optimum composition and study of specific activity of the pediatric medication form of dimedrol

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