Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone-deacetylases

Hazzouri, Mira; Pivôt-Pajot, Christophe; Faure, Anne‐Karen; Usson, Yves; Pelletier, R.; Sèle, B; Khochbin, Saadi; Rousseaux, Sophie

doi:10.1078/0171-9335-00123

Cited by 247 publications

(235 citation statements)

References 46 publications

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“…In round spermatids (R), HSPA2 is almost homogenously distributed in the nucleus, and, as previously shown, histones are found underacetylated in these cells (17). Interestingly, the wave of histone acetylation observed at stage VIII spermatids (17) is associated with a dramatic redistribution of HSPA2, which becomes concentrated in a cap-like structure penetrating into the inner side of the nucleus.…”

Section: Volume 281 • Number 49 • December 8 2006supporting

confidence: 49%

Post-meiotic Shifts in HSPA2/HSP70.2 Chaperone Activity during Mouse Spermatogenesis

Govin

Caron

Escoffier

et al. 2006

Journal of Biological Chemistry

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106

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HSPA2 (formerly HSP70.2) is a testis-specific member of the HSP70 family known to play a critical role in the completion of meiosis during male germ cell differentiation. Although abundantly present in post-meiotic cells, its function during spermiogenesis remained obscure. Here, using a global proteomic approach to identify genome-organizing proteins in condensing spermatids, we discovered an unexpected role for HSPA2, which acquires new functions and becomes tightly associated with major spermatid DNA-packaging proteins, transition proteins 1 and 2. Hence, HSPA2 is identified here as the first transition protein chaperone, and these data shed a new light on the yet totally unknown process of genome-condensing structure assembly in spermatids.

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Section: Volume 281 • Number 49 • December 8 2006supporting

confidence: 49%

Post-meiotic Shifts in HSPA2/HSP70.2 Chaperone Activity during Mouse Spermatogenesis

Govin

Caron

Escoffier

et al. 2006

Journal of Biological Chemistry

Self Cite

106

View full text Add to dashboard Cite

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“…Histones are hyperacetylated beginning at the round spermatid stage with increasing levels detectable in the elongating spermatid stage [76], [77]. This hyperacetylation is thought to facilitate global chromatin remodeling through creation of a more accessible chromatin environment.…”

Section: Global Chromatin Remodeling During Spermiogenesismentioning

confidence: 99%

Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?

Gill

Erkek

Peters

2012

Current Opinion in Cell Biology

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At fertilization, fusion of two differentiated gametes forms the zygote that is capable of forming all of the varied cell lineages of an organism. It is widely thought that the acquisition of totipotency involves extensive epigenetic reprogramming of the germline state into an embryonic state. However, recent data argue that this reprogramming is incomplete and that substantial epigenetic information passes from one generation to the next. In this review we summarize the changes in chromatin states that take place during mammalian gametogenesis and examine the evidence that early mammalian embryogenesis may be affected by inheritance of epigenetic information from the parental generation.

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“…Hyperacetylation of histone H4 occurs during the histone-to-protamine transition, perhaps causing a more open chromatin structure to facilitate histone replacement (93)(94)(95)(96) and serving as a signal for the bromodomain protein BRDT to initiate the histone-to-protamine transition (97). In mammals, reduced levels of histone H4 hyperacetylation correlates with impaired fertility (95,98).…”

Section: The Effects Of Bacterial Infection On Sperm Chromatin Condenmentioning

confidence: 99%

The Impact of Bacterial Infections on Human Spermatozoa

Zeyad¹,

Amor²,

Hammadeh³

2017

International Journal of Women’s Health and Reproduction Scienc

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Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone-deacetylases

Cited by 247 publications

References 46 publications

Post-meiotic Shifts in HSPA2/HSP70.2 Chaperone Activity during Mouse Spermatogenesis

Post-meiotic Shifts in HSPA2/HSP70.2 Chaperone Activity during Mouse Spermatogenesis

Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?

The Impact of Bacterial Infections on Human Spermatozoa

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