Regularities of the photodestruction of acridine dyes in aqueous media

Макаров, Д. А.; Kuznetsova, Nina A.; Kaliya, O. L.

doi:10.1134/s0036024406020270

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…Hence this ability of the AO@GSH-AuNPs is suitable for potential anticancer therapy to treat various cancers through photodestruction. 1,23 In vitro cytotoxicity…”

Section: Cellular Uptake Of Ao@gsh-aunpsmentioning

confidence: 99%

“…22 However the use of AO in PDT is limited due to its photodegradation by light mediated temperatures, aqueous instability, short half-life etc. 23 To overcome these complications, several recent reports have described that conjugation of PS with AuNPs actively participate in PDT as a passive drug carrier. 11,24 In this study, we evaluated the potential application of chitosan reduced AuNPs as photothermal agent as well as photosensitizer carrier system by investigating their controlled synthesis, photostability and drug loading efficacy for combined PDT and PTT against breast cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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Acridine orange tethered chitosan reduced gold nanoparticles: a dual functional probe for combined photodynamic and photothermal therapy

2013

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Plasmonic nanoparticles have been widely used in photomedicine owing to their unique photophysical properties including surface plasmon resonance, high optical extinction and extensive thermal stability, which makes metal nanoparticles more suitable for application in cancer phototherapy. Here, we exploit the appropriateness of chitosan reduced gold nanoparticles (AuNPs) as a photothermal converter, photodynamic carrier and contrast agent in the applications of bioimaging, photothermal (PTT) and photodynamic therapy (PDT), concurrently to destroy the human breast cancer cells (MCF-7). AuNPs were successfully conjugated by non-covalent interaction with hydrophilic photosensitizer, acridine orange (AO) through glutathione (GSH) to achieve improved PDT and PTT therapy. This could be attributed to the high loading efficiency with enhanced cellular uptake and excellent photothermal stability of the nanoconjugate (AO@GSH-AuNPs). In addition, the anticancer activity of the nanoconjugate in combination with blue light irradiation (l ¼ 492 nm) demonstrated a pronounced effect compared to the free AO or light irradiation. Thus results of our studies represent the dual mode action of both AO and AuNPs showing photodynamic and photothermal ablation, respectively. Our findings suggest that the AO@GSH-AuNPs nanoconjugate could be used as a multifunctional probe for anticancer therapy.

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“…Hence this ability of the AO@GSH-AuNPs is suitable for potential anticancer therapy to treat various cancers through photodestruction. 1,23 In vitro cytotoxicity…”

Section: Cellular Uptake Of Ao@gsh-aunpsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acridine orange tethered chitosan reduced gold nanoparticles: a dual functional probe for combined photodynamic and photothermal therapy

2013

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“…Heterogeneous photocatalysis based on the anatase form of TiO 2 [5-7] provides an alternative to traditional low-efficiency methods for purifying contaminated water such as flocculation, adsorption by activated carbon, or biopurification. The overwhelming majority of publications on photodegradation of dyes by Ti-containing catalysts is concerned with the analysis of photocatalysis methods in aqueous solutions [8]. The photodegradation is followed by spectral methods and bleaching of the solutions by UV or IR radiation [9], by the decrease of the total amount of carbon, or by liquid chromatography [10].…”

mentioning

confidence: 99%

Photodegradation and aggregation of acridine dyes adsorbed on the surface of mesoporous TiO2 films

et al. 2010

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Electronic spectroscopy and laser desorption/ionization (LDI) mass spectrometry have been used to study the effects of UV exposure on acridine dyes such as acridine orange (AO) and acridine yellow (AY) adsorbed on the surface of mesoporous TiO 2 films. The main stages of the photodegradation process have been identified. The first one is photooxidative N-demethylation of the dimethylamino group in AO and deamination in AY. The following stages are photodimerization and photoaggregation on the superhydrophilic TiO 2 surface and further photocatalytic decomposition to the completely mineralized dyes. Introduction.Aminoacridines are some of the most common organic dyes and are used to dye synthetic fibers and to fabricate highly efficient fluorophores [1,2]. For example, the ability of the fluorophore acridine orange (AO) to bind selectively to nucleic acids is utilized in molecular biology and biochemistry. AO fluoresces green when binding to the monomeric form to DNA; red, as a dimer complexed to RNA [3,4]. Aminoacridines exhibit antibacterial and antiviral properties and are used as disinfectants. A significant photodynamic effect with a substantial increase of their antimicrobial activity is observed in the presence of light and oxygen. Aggregation of AO affects the properties of optical devices that operate based on sensitization of a semiconductor film in the visible region by adsorbed dye molecules.Furthermore, dyes are some of the most pervasive environmental contaminants as a result of their stability and, therefore, resistance to natural biodegradation. Heterogeneous photocatalysis based on the anatase form of TiO 2 [5-7] provides an alternative to traditional low-efficiency methods for purifying contaminated water such as flocculation, adsorption by activated carbon, or biopurification. The overwhelming majority of publications on photodegradation of dyes by Ti-containing catalysts is concerned with the analysis of photocatalysis methods in aqueous solutions [8]. The photodegradation is followed by spectral methods and bleaching of the solutions by UV or IR radiation [9], by the decrease of the total amount of carbon, or by liquid chromatography [10]. Application of these methods is limited by their inadequate sensitivity and the inability to identify reaction intermediates (often more toxic than the starting contaminant) because of their short lifetime and low concentration. These problems can be solved by using laser desorption/ionization (LDI) mass spectrometry with simultaneous spectral studies of dyes adsorbed on mesoporous TiO 2 films that are transparent over a broad spectral range.We have previously studied the effect of the surface condition on photodegradation of the model dye methylene blue, for which both the spectral characteristics of the monomeric and dimeric forms [11] and the mechanism of photocatalytic degradation with mass spectrometric identification of the intermediates are well known [12]. The experimental conditions of the LDI experiment were optimized before [12][13][14]. It was sh...

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“…Durante o curso de seu estudo sobre efeitos do Acridina no protozoário causador da malária, Raab descobriu que a combinação de Acridina Vermelho e luz tinha um efeito letal na Infusoria, uma espécie de paramécio (ACKROYD et al, 2001). Corantes de Acridina são também usados como desinfetantes antibacterianos e antivírus, com suas ações antimicrobianas aumentadas substancialmente na presença de oxigênio e luz (KAPUSCINSKI et al, 1983;MAKAROV et al, 2006). O AL é um corante da família das Acridinas (Figura 1) que possui características únicas, tais como: atividade antitumoral (TOMSON et al, 1974;NAKAMURA et al, 2008), fotossensibilidade (LE BAHERS et al, 2010;TOMSON et al, 1974;ISHIKAWA et al, 1984), fototoxicidade contra bactérias, parasitas e fungos (KUSUZAKI, K. et al, 2005).…”

Section: Figura 64 Intensidade De Fosforescência Do Oxigênio Singletunclassified

Estudo da cinética e dos mecanismos de fototransformação do corante Acridina Laranja na sua interação com sistemas micro-organizados sob a ação da luz visível

Silva¹

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Ao Prof. Dr. Iouri Borissevitch, por me dar a oportunidade de trabalhar no Grupo de Fotobiofísica, pela confiança depositada e, acima de tudo, pelo enorme ensinamento ao longo desses anos. Ao meu pai, minha mãe e minha irmã, por sempre estarem presentes em minha vida, mesmo que distantes, por serem o meu porto seguro, por nunca deixarem de acreditar em mim, pelo apoio e imenso amor. Sem vocês seria impossível a conclusão deste trabalho e por isso, serei eternamente grata. Ao meu namorado Milton, pela companhia nos momentos de alegria, ajuda nos momentos de desespero, por sempre deixar tudo de lado para me ajudar e me fazer feliz. Meu amor por você é eterno! Ao Wallance, primeiramente pela sincera amizade, pela ajuda na leitura de minha dissertação, pelas caronas e lanchinhos, por sempre estar disposto a me ajudar e pela companhia de cada dia. Aos amigos de São José do Rio Preto, Glaucia e Vitor, pela enorme amizade. Aos atuais e antigos integrantes do Grupo de Fotobiofísica, em especial: a Andreia, por sua amizade, ajuda e pelas boas conversas, a Marina, pela companhia nos almoços e horas vagas. Também ao Sérgio, Danilo, Gustavo (Pudimm) e ao Ernando. Aos amigos de corredor, pelos momentos de descontração e risadas, em especial ao Jorge, Amanda, Jeam (mineiro), Éder, Flávio (buzina) e também ao Carlão. Ao Prof. Dr. Amando Siuiti Ito, pela ajuda na disponibilização de seu laboratório para a realização dos experimentos de fluorescência e espalhamento. Ao Prof. Dr. Antônio Cláudio Tedesco, por oferecer seu laboratório para a realização dos experimentos de detecção do oxigênio singleto. Ao Fernando, pelo acompanhamento e enorme ajuda nos experimentos. Ao Prof. Dr. João Barros Valim, pela utilização de seu laboratório para a preparação de amostras saturadas com oxigênio. A todos os professores do Departamento de Física e Matemática que de alguma forma me ajudaram em meu aprendizado. À secretária da pós, Nilza. À CAPES, pelo apoio financeiro através de bolsa de estudos. À USP, pela infra-estrutura fornecida. "A percepção do desconhecido é a mais fascinante das experiências. O homem que não tem os olhos abertos para o misterioso passará pela vida sem ver nada.

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Regularities of the photodestruction of acridine dyes in aqueous media

Cited by 9 publications

References 8 publications

Acridine orange tethered chitosan reduced gold nanoparticles: a dual functional probe for combined photodynamic and photothermal therapy

Acridine orange tethered chitosan reduced gold nanoparticles: a dual functional probe for combined photodynamic and photothermal therapy

Photodegradation and aggregation of acridine dyes adsorbed on the surface of mesoporous TiO2 films

Estudo da cinética e dos mecanismos de fototransformação do corante Acridina Laranja na sua interação com sistemas micro-organizados sob a ação da luz visível

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