Regular plateletpheresis increased basal concentrations of soluble P-selectin in healthy donors: Possible involvement of endothelial cell activation?

Chen, Ying; Lin, Yi‐Sheng; Lin, Haijuan; Xiao, Jing; Jiang, Li; Chen, Cen; Zhuo, Xiaofu; Huang, Wenhua; Zeng, Jia; Dettke, Markus

doi:10.1016/j.cca.2016.04.022

Cited by 2 publications

(4 citation statements)

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“…Furthermore, soluble P-selectin may be elevated disproportionately to platelet P-selectin because of the presence of selectin polymorphism that can influence P-selectin shedding [ 29 ]. On the other hand, although the major source of soluble P-selectin has undoubtedly been shown to be of platelet origin [ 50 , 51 ], in certain situations endothelial cells as an alternative source have also been suggested [ 52 ].…”

Section: The Role Of Selectins and Psgl-1 In Thrombus Developmentmentioning

confidence: 99%

The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression

Kappelmayer

Nagy

2017

BioMed Research International

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Cellular interaction is inevitable in the pathomechanism of human disease. Formation of heterotypic cellular aggregates, between distinct cells of hematopoietic and nonhematopoietic origin, may be involved in events leading to inflammation and the complex process of cancer progression. Among adhesion receptors, the family of selectins with their ligands have been considered as one of the major contributors to cell-cell interactions. Consequently, the inhibition of the interplay between selectins and their ligands may have potential therapeutic benefits. In this review, we focus on the current evidence on the selectins as crucial modulators of inflammatory, thrombotic, and malignant disorders. Knowing that there is promiscuity in selectin binding, we outline the importance of a key protein that serves as a ligand for all selectins. This dimeric mucin, the P-selectin glycoprotein ligand 1 (PSGL-1), has emerged as a major player in inflammation, thrombus, and cancer development. We discuss the interaction of PSGL-1 with various selectins in physiological and pathological processes with particular emphasis on mechanisms that lead to severe disease.

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Section: The Role Of Selectins and Psgl-1 In Thrombus Developmentmentioning

confidence: 99%

The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression

Kappelmayer

Nagy

2017

BioMed Research International

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“…Platelet transfusions are routinely needed as an essential part of treatment for patients undergoing cancer therapy, as well as for those with bleeding disorders, and for patients undergoing open-heart surgery, or organ transplantation [1]. Platelets can be harvested using plateletpheresis, a process whereby whole blood is removed from a donor, separating the blood into its components, keeping the platelets and returning the remaining blood components to the donor; or by separating platelets from units of whole blood [2,3]. Platelets must be transfused within five days of collection due to their very short shelf-life [4].…”

Section: Introductionmentioning

confidence: 99%

“…[2]. Over the years, the thrombopoietic response to plateletpheresis has been investigated [3,4,5]. After plateletpheresis, platelet counts were reported to increase by some [3,4], and was reported to fall in one study [5].…”

Section: Introductionmentioning

confidence: 99%

“…Over the years, the thrombopoietic response to plateletpheresis has been investigated [3,4,5]. After plateletpheresis, platelet counts were reported to increase by some [3,4], and was reported to fall in one study [5]. In addition, serum ferritin levels of the female donors, but not male donors, has been reported to be decreased with increasing frequency of apheresis donation [5].…”

Section: Introductionmentioning

confidence: 99%

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