Regular physical exercise in patients with type II diabetes mellitus

Nakhanakhup, C.; Moungmee, Pratoom; Appell, H.-J.; Duarte, José Alberto

doi:10.1007/s11556-006-0002-x

Cited by 8 publications

(11 citation statements)

References 46 publications

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“…It was found that aged rats developed an increase in insulin resistance represented by, significant elevation of serum glucose, serum insulin and HOMA-IR index. This finding is in agreement with previous observations [41,42] . Swim exercise training for 6 weeks was seen to reverse insulin resistance induced by aging in rats.…”

Section: Discussionsupporting

confidence: 94%

Exercise Training Prevents Age-induced Insulin Resistance in Rats: Effect on Circulating Catecholamines, Inflammatory Cytokines and Skeletal Muscle Glut4 Transporters

El-Gohary¹

2017

Am. J. Biomed. Sci.

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The incidence of insulin resistance increases with age. This work tested the effect of exercise on ageinduced insulin resistance and the possible involved mechanisms. Six groups of rats were used: 4 months old, 14 months old and 24 months old, either with and without exercise training. Swimming exercise training was performed 2h/day, 5days/week for 6 weeks. Insulin resistance was assessed by measuring serum glucose, serum insulin and homeostasis model assessment of insulin resistance (HOMA-IR) index. Serum levels of catecholamines, inflammatory cytokines and total antioxidant capacity (TAC) together with skeletal muscle Glut4 mRNA expression were assessed. Aged rats developed insulin resistance associated with increased serum catecholamines and inflammatory cytokine levels, decreased serum TAC and suppression of skeletal muscle Glut4 expressions. Exercise training reversed the developed insulin resistance and restored the values of catecholamines, inflammatory cytokines and skeletal muscle Glut4; however, it did not modify TAC. It was concluded that exercise could reverse aging-induced insulin resistance in rats by decreasing catecholamines and inflammatory cytokines production and also by increasing Glut4 expression in skeletal muscles.

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Section: Discussionsupporting

confidence: 94%

Exercise Training Prevents Age-induced Insulin Resistance in Rats: Effect on Circulating Catecholamines, Inflammatory Cytokines and Skeletal Muscle Glut4 Transporters

El-Gohary¹

2017

Am. J. Biomed. Sci.

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“…70 Exercise is used for the prevention, 71 and treatment of T2DM [72][73][74][75][76][77][78] by improving glycemic control. 43,[79][80][81][82][83][84][85][86] It is a comprehensive element of diabetes management. 87,88 A randomized trial has reported that exercise performed for 30 minutes after meal eating may provide better improvements in glycemic control for people with T2DM.…”

Section: Management Of T2dmmentioning

confidence: 99%

“…160 Further, evidence has shown that PA leads to an improvement in insulin action. 70,85,[162][163][164] This improvement in insulin action involves an enhanced sensitivity, and responsiveness of peripheral glucose uptake probably by muscle to insulin and also an increased inhibition of hepatic glucose production by insulin. 163 Besides, the improved insulin action involves glucose transport, glycogen synthesis, and glycogen synthase activation as well as amino acid transport.…”

Section: The Physiological Effects Of Physical Activity In T2dmmentioning

confidence: 99%

<p>Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes</p>

Wake¹

2020

DMSO

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Despite the improvements in clinical care of the patients, research updates, and public health interventions, there is still an increase in the prevalence, incidence, and mortality because of diabetes mellitus (DM). DM is a public health problem in both developed and developing countries. It has increased alarmingly, putting this disease in the dimension of an epidemic. Diabetes is associated with several complications which increase the risk of many serious health problems on the other side. Therefore, this review was aimed to discuss the antidiabetic effects of physical activity (PA) on type 2 DM (T2DM) by summarizing the significant studies on this topic. This review found that several studies have recommended the utilization of PA for the effective management of T2DM. PA is a non-pharmacologic therapy which is a significant strategy for the management of T2DM and is an appropriate lifestyle modification approach to be practiced by these patients. The studies showed that PA has antidiabetic effects which are evidenced by its substantial role in improving the blood glucose (BG) levels of the individuals with T2DM where it helps them to control their levels of glucose in the blood. It plays a significant role in glycemic control of this disease by lowering the BG levels through possible mechanisms such as decreasing insulin resistance, increasing production of glucose transporter type 4 (GLUT-4), lowering visceral adipose tissue (VAT), increasing pancreatic β-cell functions, using glucose for energy, and so on. In turn, the controlled glycemia helps to prevent the complications associated with uncontrolled T2DM and this would further improve the overall health of the patients and the burden on the health professionals as well. Finally, this review concludes that PA is the cornerstone in the management of T2DM. It also suggests that more attention is needed to its significance in the prevention, glycemic control, and its role in the management of the morbidity and mortality associated with T2DM. Practical PA recommendations and suggestions for the future direction of research in this area are also provided.

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“…Aging constitutes an important risk factor for insulin resistance and development of type 2 diabetes mellitus . The ability to control the blood glucose level declines during the life span and phenotype modifications in skeletal muscle, the major site for glucose disposal, seem to play an important role in this decline .…”

Section: Introductionmentioning

confidence: 99%

“…Aging constitutes an important risk factor for insulin resistance and development of type 2 diabetes mellitus. 28,35 The ability to control the blood glucose level declines during the life span 18,21,30 and phenotype modifications in skeletal muscle, the major site for glucose disposal, seem to play an important role in this decline. 13,38 In rodents, a progressive decline in skeletal muscle glucose uptake, in the absence and in the presence of insulin, was observed during the phase of growth related to weight gain, between the first and fourth months of age.…”

Section: Introductionmentioning

confidence: 99%

The effect of age on glucose uptake and GLUT1 and GLUT4 expression in rat skeletal muscle

Santos

Benite-Ribeiro

Queiróz

et al. 2011

Cell Biochemistry & Function

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During the life span, phenotypic and structural modifications on skeletal muscle contribute to a reduction on glucose uptake either in basal state or triggered by insulin, but the underlying mechanisms for this decline are not entirely identified. A reduction in the expression of skeletal muscle glucose transporters (GLUTs), glucose transporter type 1 (GLUT1) and glucose transporter type 4 (GLUT4), has been associated to such phenomena, but unlike the case of insulin, only few studies have addressed the effect of age on muscle-contraction-induced glucose uptake. The aim of the study was to investigate the influence of age on GLUT1 and GLUT4 expression in skeletal muscle and its relation to the glucose uptake induced by muscle contraction. For this purpose, soleus muscle from Wistar rats aged 4, 10, 22 and 42 weeks were isolated and electrically stimulated (30 min, 10 Hz, 20 V, 0.2 ms). After stimulation, glucose uptake and GLUT1 and GLUT4 expression and localisation were evaluated. Muscle contraction caused an increase in glucose uptake in all studied groups. In addition, the absolute rates of glucose uptake were negatively correlated with age. The expression of GLUT4 was lower in older animals, whereas no relation between age and GLUT1 expression was found. Immunohistochemistry confirmed the ontogenic effect on GLUT4 expression and suggested an age-related modification on GLUT1 distribution within the muscle fibres; for instance, this protein seems to be present mainly out of the sarcoplasm. The present findings demonstrate that the ability of muscle contraction to increase glucose uptake is not influenced by age, whereas glucose uptake under basal conditions decreases with age.

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Regular physical exercise in patients with type II diabetes mellitus

Cited by 8 publications

References 46 publications

Exercise Training Prevents Age-induced Insulin Resistance in Rats: Effect on Circulating Catecholamines, Inflammatory Cytokines and Skeletal Muscle Glut4 Transporters

Exercise Training Prevents Age-induced Insulin Resistance in Rats: Effect on Circulating Catecholamines, Inflammatory Cytokines and Skeletal Muscle Glut4 Transporters

<p>Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes</p>

The effect of age on glucose uptake and GLUT1 and GLUT4 expression in rat skeletal muscle

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