Regular physical activity prevents development of left ventricular hypertrophy in hypertension

Palatini, Paolo; Visentin, Pieralberto; Dorigatti, Francesca; Guarnieri, Carlo; Santonastaso, Massimo; Cozzio, Susanna; Pegoraro, F.; Bortolazzi, A.; Vriz, Olga; Mos, Lucio

doi:10.1093/eurheartj/ehn533

Cited by 60 publications

(36 citation statements)

References 36 publications

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“…Reduction in insulin resistance, plasma norepinephrine, plasma renin and vascular resistance can be other explaining mechanisms 33–34 . Physical activity can be used as a therapeutic choice for the treatment of hypertension and for prevention of its complications 35 , and it improves cardiac autonomic modulation and reduces risk of coronary heart diseases 36 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence, awareness and risk factors of hypertension in a large cohort of Iranian adult population

Malekzadeh

Etemadi

Kamangar

et al. 2013

Journal of Hypertension

113

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Background There is considerable variation in hypertension prevalence and awareness, and their correlates, across different geographic locations and ethnic groups. We performed this cross-sectional analysis on data from the Golestan Cohort Study (GCS). Methods Enrollment in this study occurred in 2004–2008, and included 50,045 healthy subjects from Golestan Province in northeastern Iran. Hypertension was defined as a systolic blood pressure (SBP) ≥140, a diastolic blood pressure (DBP) ≥90, a prior diagnosis of hypertension, or the use of antihypertensive drugs. Potential correlates of hypertension and its awareness were analyzed by logistic regression adjusted for sex, age, BMI, place of residence, literacy, ethnicity, physical activity, smoking, black and green tea consumption and wealth score. Results Of the total cohort participants, 21,350 (42.7%) were hypertensive. Age-standardized prevalence of hypertension, using the 2001 WHO standard world population, was 41.8% (95%CI: 38.3%–45.2%). Hypertension was directly associated with female sex, increased BMI, Turkmen ethnicity, and lack of physical activity, and inversely associated with drinking black tea and wealth score. Among hypertensive subjects, 46.2% were aware of their disease, 17.6% were receiving antihypertensive medication, and 32.1% of the treated subjects had controlled hypertension. Hypertension awareness was greater among women, the elderly, overweight and obese subjects, and those with a higher wealth score. Conclusions Hypertension is highly prevalent in rural Iran, many of the affected individuals are unaware of their disease, and the rate of control by antihypertensive medications is low. Increasing hypertension awareness and access to health services, especially among less privileged residents are recommended.

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Section: Discussionmentioning

confidence: 99%

Prevalence, awareness and risk factors of hypertension in a large cohort of Iranian adult population

Malekzadeh

Etemadi

Kamangar

et al. 2013

Journal of Hypertension

113

View full text Add to dashboard Cite

show abstract

“…Participants were categorized as follows: White non-Hispanic, African American or Black non-Hispanic, Hispanic, or other race. At Wave III, participants were in young adulthood (age [18][19][20][21][22][23][24][25][26][27], where their personal socioeconomic status may not have been predictive of their actual SES, thus socioeconomic status was measured using parent-reported family income at Wave I. Income was grouped into the following tertiles: \$20,000 per year; between $20,000 and $60,000 per year; and over $60,000 per year.…”

Section: Covariatesmentioning

confidence: 99%

“…Moreover, consistent physical activity across the lifecourse has been linked to a number of beneficial health outcomes, including lower risk for hypertension and breast cancer [18,19]. Therefore, the purpose of this study was to examine whether physical activity patterns over the lifecourse impact birth outcomes, specifically preterm birth and low birth weight.…”

Section: Introductionmentioning

confidence: 99%

Do Physical Activity Patterns Across the Lifecourse Impact Birth Outcomes?

Vamos

Flory

Sun

et al. 2015

Matern Child Health J

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The significant impact of physical activity during, or immediately prior to pregnancy on a range of pregnancy and birth outcomes has been established. However, lifecourse theory posits that the antecedents of poor outcomes occur across a larger trajectory of time. The objective of this study was to examine whether physical activity patterns over the lifecourse impact birth outcomes. The sample (n = 1,713) was derived from Waves I, III, and IV of the National Longitudinal Study of Adolescent Health and limited to women who had their first, singleton live birth between Waves III and IV; respondents who had missing data were excluded. Outcome variables included preterm birth (<37 weeks) and low birth weight (<5.5 pounds). Physical activity was categorized as follows: long-term physically active (active at Waves I and III); short-term physically active (active at only Wave I or III); and not physically active (not active at Waves I and III). Survey-weighted logistic regression controlled for socio-demographic and established predictors of poor birth outcomes. Women categorized as long-term physically active had lower rates of preterm births (12.2 vs. 18.7 %) and low birth weight (9.1 vs. 11.1 %) compared to women categorized as not physically active. However, when controlling for covariates, adjusted analysis revealed that physical activity consistency only predicted preterm birth (aOR = 0.55, 95 % CI = 0.33-0.91). Findings suggest that physical activity patterns across the lifecourse may decrease risk of preterm birth. Implications include efforts supporting patterns of physical activity over longer periods of time prior to pregnancy.

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“…However, an eight-year longitudinal study in mildly hypertensive individuals showed that chronic moderate physical activity did not actually induce physiological hypertrophic remodeling, but merely prevented pathological remodeling (Palatini et al 2009). Therefore, AET may improve or prevent cardiac remodeling following cardiac insults.…”

Section: Physiological Hypertrophymentioning

confidence: 99%

Evidence for distinct effects of exercise in different cardiac hypertrophic disorders

2015

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Aerobic exercise training (AET) attenuates or reverses pathological cardiac remodeling after insults such as chronic hypertension and myocardial infarction. The phenotype of the pathologically hypertrophied heart depends on the insult; therefore, it is likely that distinct types of pathological hypertrophy require different exercise regimens. However, the mechanisms by which AET improves the structure and function of the pathologically hypertrophied heart are not well understood, and exercise research uses highly inconsistent exercise regimens in diverse patient populations. There is a clear need for systematic research to identify precise exercise prescriptions for different conditions of pathological hypertrophy. Therefore, this review synthesizes existing evidence for the distinct mechanisms by which AET benefits the heart in different pathological hypertrophy conditions, suggests strategic exercise prescriptions for these conditions, and highlights areas for future research.

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Regular physical activity prevents development of left ventricular hypertrophy in hypertension

Abstract: Regular physical activity prevents the development of LVH in young stage 1 hypertensive subjects. This effect is independent from the reduction in blood pressure caused by exercise.

Cited by 60 publications

References 36 publications

Prevalence, awareness and risk factors of hypertension in a large cohort of Iranian adult population

Prevalence, awareness and risk factors of hypertension in a large cohort of Iranian adult population

Do Physical Activity Patterns Across the Lifecourse Impact Birth Outcomes?

Evidence for distinct effects of exercise in different cardiac hypertrophic disorders

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