Regular Consumption of Both Vitamin D– and Calcium- and Vitamin D–Fortified Yogurt Drink Is Equally Accompanied by Lowered Blood Lipoprotein (a) and Elevated Apoprotein A1 in Subjects with Type 2 Diabetes: A Randomized Clinical Trial

Heravifard, Soudabeh; Neyestani, Tirang R.; Nikooyeh, Bahareh; Majd, Hamid Alavi; Houshiarrad, Anahita; Kalayi, Ali; Shariátzadeh, Nastaran; Zahedirad, Maliheh; Tayebinejad, Nima; Salekzamani, Shabnam; Khalaji, Niloufar; Gharavi, Abdolsamad

doi:10.1080/07315724.2013.767659

Cited by 34 publications

(18 citation statements)

References 22 publications

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“…Defects of respiratory burst and resulting decreased killing ability of phagocytes is often accompanied by the increased susceptibility to the opportunistic pathogens. Chronic granulomatous disease is the prototype of such conditions .…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress, type 2 diabetes and vitamin D: past, present and future

Nikooyeh

2015

Diabetes Metabolism Res

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Oxidative stress refers to an imbalance between potentially harmful free radicals and the body's mechanisms to efficiently detoxify them in favor of the free radicals. Consequently, excess free radicals can attack and damage a wide range of biomolecules including proteins, lipids and nucleic acids. Antioxidant mechanisms of the body are under the influence of genetic and environmental (including dietary) factors. Diabetes is one of the most common metabolic disorders around the world. A huge body of evidence indicates a role for oxidative stress in development of many human diseases including diabetes. In this article, the latest information on the possible links of oxidative stress with diabetes development, control and complications as well as the newest results of antioxidant supplementation trials is reviewed. In addition, the possible role of vitamin D, as a newly recognized antioxidant in diabetes is discussed. Finally, concluding remarks on pivotal issues and future studies are presented.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress, type 2 diabetes and vitamin D: past, present and future

Nikooyeh

2015

Diabetes Metabolism Res

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“…Variations in study design and duration, sample size, quantity and type of dairy, and habitual dairy/calcium intakes prior to the study are important factors to consider. Clinical trials have investigated the effect of yogurt enriched with vitamin D and/or calcium in individuals with type 2 diabetes and observed an improvement in glycemia [60][61][62], lipid profiles, and endothelial biomarkers [60,62]. In a 9-week clinical study, pregnant women were randomly assigned to consume 200 g per day of conventional yogurt or probiotic yogurt containing Streptococcus thermophilus and Lactobacillus bulgaricus to examine the effect on fasting plasma glucose and serum insulin concentrations.…”

Section: Clinical Studiesmentioning

confidence: 99%

The Potential Role of Yogurt in Weight Management and Prevention of Type 2 Diabetes

Panahi

Tremblay

2016

Journal of the American College of Nutrition

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Yogurt is a semisolid fermented milk product that originated centuries ago and is viewed as an essential food and important source of nutrients in the diet of humans. Over the last 30 years, overweight and obesity have become characteristic of Western and developing countries, which has led to deleterious health outcomes, including cardiovascular disease, type 2 diabetes, hypertension, and other chronic conditions. Recent epidemiological and clinical evidence suggests that yogurt is involved in the control of body weight and energy homeostasis and may play a role in reducing the risk for type 2 diabetes partly via the replacement of less healthy foods in the diet, its food matrix, the effect of specific nutrients such as calcium and protein on appetite control and glycemia, and alteration in gut microbiota. This review will discuss the specific properties that make yogurt a unique food among the dairy products, epidemiological and clinical evidence supporting yogurt's role in body weight, energy balance, and type 2 diabetes, including its potential mechanisms of action and gaps that need to be explored. Key teaching points • Several epidemiological and clinical studies have suggested a beneficial effect of yogurt consumption in the control of body weight and energy homeostasis, although this remains controversial. • Yogurt possesses unique properties, including its nutritional composition; lactic acid bacteria, which may affect gut microbiota; and food matrix, which may have a potential role in appetite and glycemic control. • Potential mechanisms of action of yogurt include an increase in body fat loss, decrease in food intake and increase in satiety, decrease in glycemic and insulin response, altered gut hormone response, replacement of less healthy foods, and altered gut microbiota. • The relative energy and nutrient content and contribution of a standard portion of yogurt to the overall diet suggest that the percentage daily intake of these nutrients largely contributes to nutrient requirements and provides a strong contribution to the regulation of energy metabolism.

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“…In addition, sphingolipids did not change postprandial apoA-I concentrations [140]. On the other hand, red grape juice [141], a mixture of citrus flavonoids and tocotrienols [142], vitamin D supplementation [143, 144], vitamin D plus calcium supplementation [144], theobromine [145], orange juice [146], and a high dose of grape pomace and omija fruit [147] all increased fasting apoA-I concentrations (Table 9). …”

Section: Dietary Interventions Affecting Apoa-i Metabolismmentioning

confidence: 99%

Dietary Strategies and Novel Pharmaceutical Approaches Targeting Serum ApoA-I Metabolism: A Systematic Overview

Smolders

Mensink

2017

Journal of Nutrition and Metabolism

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The incidence of CHD is still increasing, which underscores the need for new preventive and therapeutic approaches to decrease CHD risk. In this respect, increasing apoA-I concentrations may be a promising approach, especially through increasing apoA-I synthesis. This review first provides insight into current knowledge on apoA-I production, clearance, and degradation, followed by a systematic review of dietary and novel pharmacological approaches to target apoA-I metabolism. For this, a systematic search was performed to identify randomized controlled intervention studies that examined effects of whole foods and (non)nutrients on apoA-I metabolism. In addition, novel pharmacological approaches were searched for, which were specifically developed to target apoA-I metabolism. We conclude that both dietary components and pharmacological approaches can be used to increase apoA-I concentrations or functionality. For the dietary components in particular, more knowledge about the underlying mechanisms is necessary, as increasing apoA-I per se does not necessarily translate into a reduced CHD risk.

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Regular Consumption of Both Vitamin D– and Calcium- and Vitamin D–Fortified Yogurt Drink Is Equally Accompanied by Lowered Blood Lipoprotein (a) and Elevated Apoprotein A1 in Subjects with Type 2 Diabetes: A Randomized Clinical Trial

Abstract: Significant amelioration of serum Apo A1 and Lp(a) following improvement of vitamin D status in T2D subjects may have preventive implications against long-term diabetic complications, notably CVD. This trial was registered at ClinicalTrials.gov as NTC01229891.

Cited by 34 publications

References 22 publications

Oxidative stress, type 2 diabetes and vitamin D: past, present and future

Oxidative stress, type 2 diabetes and vitamin D: past, present and future

The Potential Role of Yogurt in Weight Management and Prevention of Type 2 Diabetes

Dietary Strategies and Novel Pharmaceutical Approaches Targeting Serum ApoA-I Metabolism: A Systematic Overview

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