Régression spontanée de cancers mammaires après biopsie : à propos de deux cas

Maillet, L.; Chopin, Nicolás; Treilleux, Isabelle; Bachelot, Thomas; Trédan, Olivier; Faure, C.; Caux, Christophe; Beurrier, F.

doi:10.1016/j.gyobfe.2013.08.017

Cited by 9 publications

(10 citation statements)

References 10 publications

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“…Six studies were included. 2,[42][43][44][45][46] (Prisma flow chart in Supporting Information Appendix 3 Fig. 3).…”

Section: Regressive Cancersmentioning

confidence: 99%

“…Characteristic of included studies and results. Of the included studies, two were cohort studies, 2,46 three case reports, 42,43,45 one a case series. 44 Cohort studies.…”

Section: Regressive Cancersmentioning

confidence: 99%

“…2,46 We also retrieved one case series study counting complete replacement of carcinoma by fibrous tissue in resected specimen of 308 women who received BCS without neoadjuvant chemotherapy 44 and three case reports of cases of BC spontaneous regression. 42,43,45 Zahl in his publication of 2008 46 and 2011 2 argue that 75% (345 of 458 per 100,000) of all extra BCs discovered in the first two screening rounds in Sweden and more than half (174 of 324 per 100,000) discovered in Norway would have "regressed" before screening in years five and six. The reported relative risk of regressing (and detected) BC is 1.2 and 1.14, in Sweden and Norway, respectively.…”

Section: Regressive Cancersmentioning

confidence: 99%

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Epidemiologic evidence of slow growing, nonprogressive or regressive breast cancer: A systematic review

et al. 2016

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The general aim of this systematic review is to mitigate breast cancer (BC) overdiagnosis and overtreatment. The specific aim is to summarize available data on the occurrence and features of indolent invasive or in situ (DCIS) BC, and precisely survival of untreated cases, prevalence of occult cancers found in autopsies, frequency of regressive BC. PubMed, Embase and Cochrane Library were systematically searched up to 3/31/2014. Eligibility criteria were: cohort studies, case-control studies, uncontrolled case series assessing survival in women with a diagnosis of BC who did not receive treatment compared to treated women; case series of autopsies estimating the prevalence of undiagnosed BC; cohort studies, case-control studies, uncontrolled case series, case reports assessing the occurrence of spontaneous regression of BC in women with a confirmed histology diagnosis. Untreated BC: 8 cohort studies and 12 case series (3593 BC) were included. In three controlled cohort studies (diagnoses 1978-2006), the 5-years overall survival was 19-43%. Occult BC: 8 case series (2279 autopsies) were included. The prevalence of invasive BC undiagnosed during lifetime range was 0-1.5%, while for DCIS the range was 0.2-14.7%. Spontaneous regression: 2 cohort studies, 3 case reports, 1 case series included. In the cohort studies the relative risk of regression for screen detected compared with nonscreened BC was estimated as 1.2 and 1.1. It seems plausible that around 10% of invasive BC are not symptomatic during life, and that one fith of BC patients if untreated would be alive after 5 years. Around 1 of 10 screen-detected BC may regress according two studies.There is a long standing debate on breast cancer (BC) natural history.1,2 A model suited to the current understanding of cancer biology includes cases with rapid development or early dissemination, cases likely to progress slowly if untreated, and indolent or regressive lesions. 3BC screening has contributed to the understanding of the complexity of the natural history of the neoplastic process. It allowed to detect early preclinical stages and to improve the diagnostic process aiming at identifying and treating those conditions most likely associated with morbidity and mortality.

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“…Six studies were included. 2,[42][43][44][45][46] (Prisma flow chart in Supporting Information Appendix 3 Fig. 3).…”

Section: Regressive Cancersmentioning

confidence: 99%

“…Characteristic of included studies and results. Of the included studies, two were cohort studies, 2,46 three case reports, 42,43,45 one a case series. 44 Cohort studies.…”

Section: Regressive Cancersmentioning

confidence: 99%

Section: Regressive Cancersmentioning

confidence: 99%

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Epidemiologic evidence of slow growing, nonprogressive or regressive breast cancer: A systematic review

et al. 2016

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“…The postoperative assessment either showed necrosis with inflammatory cells [5] or, as in the presented case, a fibrotic tumour bed with inflammatory cells [7]. The phenotype of the tumours has been rarely reported, but it seems that oestrogen receptor-positive carcinomas have also regressed spontaneously [5], or on corticosteroid alone [4], although the phenomenon might be more common in triple-negative carcinomas [6] or oestrogen and progesterone receptor negative carcinomas when HER2 was not tested [3]. Our spontaneously regressive case seems to represent a basal-like carcinoma on the basis of the triple-negative phenotype, and diffuse CK5 and p53 expression [10].…”

Section: Discussionmentioning

confidence: 86%

“…Even the rare case reports on spontaneously regressive breast cancer are heterogeneous: they include partial or nearly complete regression [4,5], and complete regression cases [3,4]. The preoperative diagnosis of spontaneously regressive breast cancers is also variable, some rely on fine needle aspirates only [5,7], and a few have a tissue diagnosis by core needle biopsy [3,6], allowing the assessment of the lymphoid component at diagnosis. The postoperative assessment either showed necrosis with inflammatory cells [5] or, as in the presented case, a fibrotic tumour bed with inflammatory cells [7].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis

Serfőző¹,

Ambrózay²,

Markó

et al. 2019

pjp

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We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth.

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Spontanremissionen

Kappauf¹

2021

Springer Reference Medizin

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Régression spontanée de cancers mammaires après biopsie : à propos de deux cas

Cited by 9 publications

References 10 publications

Epidemiologic evidence of slow growing, nonprogressive or regressive breast cancer: A systematic review

Epidemiologic evidence of slow growing, nonprogressive or regressive breast cancer: A systematic review

Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis

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