Regression of Rous Sarcomas in Two Lines of Chickens ,

Cotter, P. F.; Collins, W. M.; Corbett, A. C.; Dunlop, W.

doi:10.3382/ps.0520799

Cited by 17 publications

(12 citation statements)

References 3 publications

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“…Inhibition was significantly less when the cells were obtained from chickens with progressively growing wing web tumors or from uninoculated controls. We have previously shown that the incidence of regression of Rous sarcomas is significantly influenced by the particular line of chickens (Cotter et al, 1973a), the presence of thymus tissue (Cotter et al, 1976), and the host age at inoculation (Cotter et al, 1973b). The data suggest that tumor regression in chickens is mediated by a delayed type hypersensitivity reaction in which thymus dependent cells (T cells) become sensitized to and subsequently effect the destruction of tumor cells.…”

Section: Discussionmentioning

confidence: 96%

Detection of Cellular Immunity to Rous Tumors of Chickens by the Leukocyte Migration Inhibition Reaction

et al. 1976

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Section: Discussionmentioning

confidence: 96%

Detection of Cellular Immunity to Rous Tumors of Chickens by the Leukocyte Migration Inhibition Reaction

et al. 1976

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“…of a 10" 3 dilution of the stock virus. Tumors usually appeared on the ninth or tenth day post-inoculation (PI) and were subjectively scored for size according to the procedure of Cotter et al (1973). A progressor was a chicken bearing a tumor either increasing, or plateaued, in size by 70 days PI whereas a regressor was a host whose tumor clearly was decreasing in size or had disappeared completely in the same time period.…”

Section: Chickensmentioning

confidence: 99%

“…Rous sarcoma regression was studied by Cotter et al (1973) in an inbred line of White Leghorns and a non-inbred line of New Hampshires, each of which was genetically susceptible to RSV. The frequency of spontaneous tumor regression in the inbred Leghorns exceeded 50% and in the New Hampshires was approximately 5%, the difference between lines being statistically significant.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Progressive Versus Regressive Rous Virus-induced Avian Sarcomas According to Tumor and Infiltrating Lymphocyte Fine Structure , ,

et al. 1978

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Electron microscope examination of progressing and regressing Rous virus-induced sarcomas in an inbred line of White Leghorns revealed that regressing tumors contained moderate to marked lymphocyte infiltration, frequent contact between lymphocytes and tumor cells, and extensive areas of necrosis. Lymphocytes infiltrating regressing tumors exhibited a polar accumulation of organelles at the point of contact between lymphocyte and target cell. On the other hand, progressing tumors contained low to moderate numbers of lymphocytes, infrequent lymphocyte-tumor cell interaction and less evidence of tumor cell degeneration. Lymphocytes from progressing tumors lacked the polar organization of organelles. This experimental system is offered as a means of studying the role of lymphocytes in tumor regression.

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“…In chickens, Rous sarcomas may regress spontaneously (Stenkvist and Ponten, 1963), but the incidence of tumor regression was influenced significantly by strain (Cotter et al, 1973), genetic selection (Gyles and Brown, 1971;Carte et ah, 1972), and by the major histocompatibility complex (Collins et al, 1977;Schiermznetal, 1977).…”

Section: Introductionmentioning

confidence: 97%

Influence of Genotype and Protein-Calorie Restriction upon RSV-Induced Tumors in Chickens ,

1980

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Development of Rous sarcoma virus-induced tumors was studied in chickens with protein and calories restricted to 60% of that of full-fed animals using two genetic models. In the first, an inbred line (RPRL 6 3 ) and a noninbred line (UNH 105) were utilized. In the second, B locus alloantigen segregants from the F 2 generation of a cross of two inbred lines (RPRL 6, and RPRL 151) were used. All chickens were susceptible genetically to subgroup A tumor virus. Tumors were subjectively scored for size (0 = no tumor; 6 = massive tumor) several times during the experiment and an index assigned to each chicken based upon time of tumor regression and whether or not the chicken died with progressive tumor.Under model 1, susceptibility to Rous tumor formation was reduced in noninbred compared to inbred chickens. Protein-calorie restriction reduced mean tumor size at both 2 and 3 weeks postinoculation (PI) by .8 score compared to full-fed chickens. Line did not significantly affect days to first appearance of tumor, mean tumor score, or tumor profile index. Under model 2, feed restriction delayed the appearance of tumor by 1.6 days and reduced mean tumor size at 2, 3, and 4 weeks after inoculation by .7, .6, and .5 score, respectively, compared to full-fed chickens. Chickens of B 2 B* genotype had smaller tumors between 3 and 10 weeks PI and a smaller mean tumor profile index than B s B 5 chickens.

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Regression of Rous Sarcomas in Two Lines of Chickens ,

Abstract: A genetic difference between two lines of chickens in the incidence of regression of Rous sarcomas was found.

Cited by 17 publications

References 3 publications

Detection of Cellular Immunity to Rous Tumors of Chickens by the Leukocyte Migration Inhibition Reaction

Detection of Cellular Immunity to Rous Tumors of Chickens by the Leukocyte Migration Inhibition Reaction

Differentiation of Progressive Versus Regressive Rous Virus-induced Avian Sarcomas According to Tumor and Infiltrating Lymphocyte Fine Structure , ,

Influence of Genotype and Protein-Calorie Restriction upon RSV-Induced Tumors in Chickens ,

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