Differentiation of Progressive Versus Regressive Rous Virus-induced Avian Sarcomas According to Tumor and Infiltrating Lymphocyte Fine Structure , ,

Perry, Linda L.; Wight, Thomas N.; Collins, W. M.; Dunlop, W.

doi:10.3382/ps.0570080

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Controversy, however, exists about the participation of other cell types. Histopathological observations in both chickens (Stenkvist and Ponten, 1963;Perry et al, 1978) and quails (Yoshikawa et al, 1975) have implicated the lymphocyte as the major infiltrating cell type. It has been suggested, therefore, that macrophages function as mere scavengers in the ASV-system without participating in the anti-tumor defense.…”

Section: Introductionmentioning

confidence: 97%

Effector Mechanisms Against Rous Sarcomas in Quail

Fleischer

Bauer

1983

Poultry Science

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The inhibitory effect on tumor growth of thymus-derived cells in the avian virus system has been demonstrated by several investigators. Here we report two kinds of experiments performed to test the role of various potential effector cells in the immune response against Rous sarcomas. In vivo experiments in Japanese quail using the antimacrophage agent silica implicate the macrophage as a further mechanism in the defense against Rous sarcoma virus-induced tumors. Induction of a nonspecific inflammation at the site of tumor development led to reduced tumor growth.

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Section: Introductionmentioning

confidence: 97%

Effector Mechanisms Against Rous Sarcomas in Quail

Fleischer

Bauer

1983

Poultry Science

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“…Studies have shown that tumor-infiltrating lymphocytes are present in tumor tissues and play an important role in tumor development, regression, and treatment in cancer patients [147][148][149]. Adoptive cell therapy with TIL in combination with cyclophosphamide and IL-2 cured advanced hepatic metastases and pulmonary metastases in mice [150].…”

Section: Tumor-infiltrating Lymphocyte (Til) Therapymentioning

confidence: 99%

Advances and Prospects in Cancer Immunotherapy

Zhou

2014

New Journal of Science

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Cancer immunotherapy is a promising and effective treatment modality for patients with cancers. Cytokine, anticytokine, and antibody therapies appear to be effective in treating various forms of cancer. The human papillomavirus vaccine is protective for cervical cancer, and this discovery has paved the way to the development of cancer vaccines for other forms of virus-associated cancers such as liver cancer and Merkel cell carcinoma. Clinical trials have demonstrated that adoptive cell therapy using tumorinfiltrating lymphocytes can induce tumor regression in approximately 75% of metastatic melanoma patients, suggesting the possibility of using similar technique to effectively treat breast, lung, and renal cancers in the near future. Besides, genetically engineered T cells transduced with genes encoding specific T cell receptors and chimeric antigen receptors have been shown effective in the treatment of cancer patients. These studies suggest that combination therapies are superior choices in cancer immunotherapy for patients.

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The Leukocyte Response of Japanese Quail to Rous Sarcoma Virus-Induced Tumors

Me¹,

Rk²,

Nb³

1994

Avian Diseases

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In male Japanese quail, different circulating leukocyte responses were observed for progressors (birds developing a massive tumor that persisted throughout the experiment) and regressors (birds developing a tumor that gradually disappeared) after initial challenge with Rous sarcoma virus (RSV). Blood was sampled before and at weekly intervals postinoculation. Blood smears were prepared and stained with Diff Quik, and a light microscope (1000 x) was used in a direct count of 50 fields. Leukocytes were classified as heterophils, lymphocytes, monocytes, or eosinophils. The significant increase (P < 0.05) in total leukocytes at 14 days in regressors and progressors was consistent with the increase in tumor growth. The regressors' individual percentage of leukocytes did not deviate from control values, whereas the progressors' percentages of heterophils and monocytes were significantly higher (P < 0.05) and of lymphocytes significantly lower (P < 0.05) than those of controls by 14 days postinoculation. Indicative of this was the progressors' heterophil to lymphocyte ratio, which was significantly higher (P < 0.05) than that of controls 14 days post RSV challenge and remained elevated throughout the experiment. These findings suggest that the progressors' immune response is suppressed by proliferation of malignant cells. Therefore, the heterophil to lymphocyte ratio may be used in addition to tumor size to identify those birds that will regress RSV-induced tumors.

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Differentiation of Progressive Versus Regressive Rous Virus-induced Avian Sarcomas According to Tumor and Infiltrating Lymphocyte Fine Structure , ,

Cited by 3 publications

References 19 publications

Effector Mechanisms Against Rous Sarcomas in Quail

Effector Mechanisms Against Rous Sarcomas in Quail

Advances and Prospects in Cancer Immunotherapy

The Leukocyte Response of Japanese Quail to Rous Sarcoma Virus-Induced Tumors

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