Advances and Prospects in Cancer Immunotherapy

Zhou, Juhua

doi:10.1155/2014/745808

Cited by 22 publications

(10 citation statements)

References 165 publications

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“…This is a new approach which consists of inducing anti-tumor immunity by enhancing CD4 + and CD8 + T cells and thus inhibiting tumor expansion as described by Leavy (2012). It has been recorded that immunological methods that remove and/or activate anti-tumor immunity can be very effective in the treatment of cancer (Zhou 2014).…”

Section: Discussionmentioning

confidence: 99%

Thermal treatment of luteolin-7-O-β-glucoside improves its immunomodulatory and antioxidant potencies

Maâtouk

Mustapha

Mokdad-Bzéouich

et al. 2017

Cell Stress and Chaperones

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Phytochemicals extracted from flowers, roots and bark, leaves, and other plant sources have been used extensively throughout human history with varying levels of efficacy in prevention and treatment of disease. Recently, advanced methods for characterization and clinical use of these materials have allowed modern understanding of their properties to be used as immunomodulatory agents that act by enhancement of endogenous cytoprotective mechanisms, avoiding interference with normal physiologic signaling and highly effective medical treatment with minimal adverse side effects. Simple methods have been identified for improving their biological effects, such as thermal conditioning by heating or freezing-prominent example being heat treatment of lycopene and tetrahydrocannabinol. The present investigation shows improvement of the ability of heat to augment splenocyte proliferation, natural killer (NK) cell activities, and antioxidant capacity of the flavonoid luteolin-7-O-β-glucoside (L7G) in comparison with the native (non heat-treated) molecule, while further demonstrating that both the native and the heat-treated variants exhibit comparable antioxidant properties, as evidenced by their effects in macrophages by inhibition of nitric oxide production and lysosomal enzyme activity in experiments that strengthen lysosomal membrane integrity. Outcomes of these studies suggest that heat-treated L7G shows promise for use in immunotherapy, including anti-cancer regimens, as shown by its improvement of NK cell cytotoxicity.

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Section: Discussionmentioning

confidence: 99%

Thermal treatment of luteolin-7-O-β-glucoside improves its immunomodulatory and antioxidant potencies

Maâtouk

Mustapha

Mokdad-Bzéouich

et al. 2017

Cell Stress and Chaperones

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“…Сегодня для иммунотерапии опухолей используют различные средства, включая цитокины (например, ГМ-КСФ и интерлейкин 2), онколитические вирусы, адоптивный клеточный перенос (например, адоптивная Т-клеточная терапия), ингибиторы контрольных точек иммунной системы (например, CTLA-4, PD-1), и терапевтические противоопухолевые вакцины (дендритноклеточные, ДНК-или РНК-вакцины, пептидные вакцины) [4].…”

Section: Introductionunclassified

Cancer vaccine adjuvants

Барышникова

Косоруков

2019

Rossijskij bioterapevtičeskij žurnal

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Adjuvants are important components of cancer vaccines because they enhance immune responses to vaccination. However, adjuvants licensed for clinical use, e. g. aluminum salts, fail to stimulate an effective immune response. Research and development of new adjuvants with combined functions, including immune stimulation and antigen delivery, are a vital task for antitumor immunotherapy. Clinical trials of immune stimulating compounds, in particular Toll-like receptor (TLR) ligands, reveal their therapeutic potential as both antitumor agents and vaccine adjuvants.

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“…In recent years, scientific advances have expanded our understanding of the immune system and its response to malignant cells. The clinical goal of tumor immunotherapy is to provide either passive or active immunity against malignancies by harnessing the immune system to target tumors ( 8 , 9 ). The immune system’s natural capacity to detect and destroy abnormal (cancer) cells may prevent the development of many cancers ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular Imaging: A Useful Tool for the Development of Natural Killer Cell-Based Immunotherapies

Gangadaran

Ahn

2017

Front. Immunol.

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Molecular imaging is a relatively new discipline that allows visualization, characterization, and measurement of the biological processes in living subjects, including humans, at a cellular and molecular level. The interaction between cancer cells and natural killer (NK) cells is complex and incompletely understood. Despite our limited knowledge, progress in the search for immune cell therapies against cancer could be significantly improved by dynamic and non-invasive visualization and tracking of immune cells and by visualization of the response of cancer cells to therapies in preclinical and clinical studies. Molecular imaging is an essential tool for these studies, and a multimodal molecular imaging approach can be applied to monitor immune cells in vivo, for instance, to visualize therapeutic effects. In this review, we discuss the usefulness of NK cells in cancer therapies and the preclinical and clinical usefulness of molecular imaging in NK cell-based therapies. Furthermore, we discuss different molecular imaging modalities for use with NK cell-based therapies, and their preclinical and clinical applications in animal and human subjects. Molecular imaging has contributed to the development of NK cell-based therapies against cancers in animal models and to the refinement of current cell-based cancer immunotherapies. Developing sensitive and reproducible non-invasive molecular imaging technologies for in vivo NK cell monitoring and for real-time assessment of therapeutic effects will accelerate the development of NK cell therapies.

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Advances and Prospects in Cancer Immunotherapy

Cited by 22 publications

References 165 publications

Thermal treatment of luteolin-7-O-β-glucoside improves its immunomodulatory and antioxidant potencies

Thermal treatment of luteolin-7-O-β-glucoside improves its immunomodulatory and antioxidant potencies

Cancer vaccine adjuvants

Molecular Imaging: A Useful Tool for the Development of Natural Killer Cell-Based Immunotherapies

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