Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection

Bayerdörffer, Ekkehard; Rudolph, Bernd; Neubauer, Andreas; Thiede, Christian; Lehn, Norbert; Eidt, Sebastian; Stolte, Manfred

doi:10.1016/s0140-6736(95)90113-2

Cited by 845 publications

(469 citation statements)

References 24 publications

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“…5,6 In early phases, this tumor is sensitive to withdrawal of H. pylori-induced T-cell help, providing an explanation for both the tumor's tendency to remain localized to the primary site and its regression after H. pylori is eradicated with antibiotics. 7,8 Tumor growth may depend on evasion from T cellmediated cytotoxicity. 9 Two cytotoxic mechanisms are known 10 : the first involves local release of perforins and granzymes by effector T cells and leads to lysis of target cells, 11 and the second induces apoptosis upon the interaction of Fas ligand expressed by T cells with Fas on target cells.…”

mentioning

confidence: 99%

Impaired T-cell regulation of B-cell growth in Helicobacter pylori–related gastric low-grade MALT lymphoma

D’Elios¹,

Amedei²,

Manghetti³

et al. 1999

Gastroenterology

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confidence: 99%

Impaired T-cell regulation of B-cell growth in Helicobacter pylori–related gastric low-grade MALT lymphoma

D’Elios¹,

Amedei²,

Manghetti³

et al. 1999

Gastroenterology

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“…11 In the literature, tumour regression after eradication of H pylori with a similar median follow up varied markedly from 41% to 100% (table 2). [4][5][6][7][8][9][10][11] In the present study, complete regression of histological lesions was obtained in 43% of cases and concerned all localised tumours in stages I E and II E1 , whatever their H pylori status.…”

Section: Discussionmentioning

confidence: 53%

“…1 Since the first cases of GL regression after such eradication were reported in 1993, 2 3 various remission rates of 41-100% have been published for several low grade GL series. [4][5][6][7][8][9][10][11] These variations may be due to the heterogeneity of these series, particularly as regards clinical presentation and tumour characteristics. In fact, data are sometimes lacking concerning H pylori infection status and/or tumour extension and stage.…”

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confidence: 99%

Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment

&NA;

2001

European Journal of Gastroenterology & Hepatology

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Background and aims-Discrepant remission rates (41-100%) have been reported for patients with localised low grade gastric mucosa associated lymphoid tissue (MALT) lymphoma after eradication of Helicobacter pylori. The aim of this study was to explain these discrepancies and to determine the predictive factors of gastric lymphoma regression after anti-H pylori treatment. Patients and methods-Forty six consecutive patients with localised gastric MALT lymphoma (Ann Arbor stages I E and II E ) were prospectively enrolled. All had gastric endoscopic ultrasonography and H pylori status assessment (histology, culture, polymerase chain reaction, and serology). After anti-H pylori treatment, patients were re-examined every four months. Results-Histological regression of the lymphoma was complete in 19/44 patients (43%) (two lost to follow up). Median follow up time for these 19 responders was 35 months (range 10-47). No regression was noted in the 10 H pylori negative patients. Among the 34 H pylori positive patients, the H pylori eradication rate was 100%; complete regression rate of the lymphoma increased from 56% (19/34) to 79% (19/24) when there was no nodal involvement at endoscopic ultrasonography. There was a significant diVerence between the response of the lymphoma restricted to the mucosa and other more deep seated lesions (p<0.006). However, using multivariate analysis, the only predictive factor of regression was the absence of nodal involvement (p<0.0001). Conclusion-In H pylori positive patients with localised gastric MALT lymphoma, carefully evaluated and treated without any lymph node involvement assessed by endoscopic ultrasonography, complete remission of lymphoma was reached in 79% of cases. (Gut 2001;48:297-303)

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“…4 -14 (10) 1 (9) 3 (10) FM: flutorabine and mitoxantrone; CVP: cyclophosphamide, vincristine, and prednisone. Whereas Helicobacter pylori eradication has provided an effective form of management for gastric MALT lymphomas, [25][26][27] nongastrointestinal presentation most often requires frontline chemotherapy. Radiotherapy cannot be used to treat tumors in the lung or liver, while in the eye, for example, radiotherapy use carries a high risk of local toxicity, due to periorbital soft tissue localization.…”

Section: Discussionmentioning

confidence: 99%

Fludarabine‐containing chemotherapy as frontline treatment of nongastrointestinal mucosa‐associated lymphoid tissue lymphoma

Zinzani

Stefoni

Musuraca

et al. 2004

Cancer

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BACKGROUNDMucosa‐associated lymphoid tissue (MALT) lymphoma is a specific clinicopathologic entity with gastric and nongastrointestinal site involvement. The authors reported the clinical outcome of patients with Stage IE nongastrointestinal MALT lymphoma treated with a frontline fludarabine‐containing regimen or with a regimen containing cyclophosphamide, vincristine, and prednisone (CVP).METHODSBetween 1998 and 2001, 31 patients with Stage IE disease were referred to the Seràgnoli Institute of Hematology and Medical Oncology at the University of Bologna (Bologna, Italy). Presenting sites included periorbital soft tissue (n = 8), lung (n = 5), skin (n = 5), salivary glands (n = 5), lacrimal glands (n = 5), and thyroid (n = 3). Twenty patients were treated with fludarabine and mitoxantrone (FM), and 11 were treated with the CVP regimen. The median follow‐up was 3 years.RESULTSAll patients achieved complete responses (CR). Four patients, all treated with CVP, experienced disease recurrence and then achieved a second CR after FM salvage treatment. No tumor recurrence was observed in patients with thyroid, lacrimal gland, or pulmonary lymphoma. The projected 5‐year overall survival and disease‐free survival rates were 100% and 85%, respectively.CONCLUSIONSThe fludarabine‐containing FM regimen provided a relatively effective frontline (or salvage) treatment option for patients with nongastrointestinal Stage IE MALT lymphoma and probably was superior to CVP in terms of efficacy. Cancer 2004. © 2004 American Cancer Society.

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Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection

Cited by 845 publications

References 24 publications

Impaired T-cell regulation of B-cell growth in Helicobacter pylori–related gastric low-grade MALT lymphoma

Impaired T-cell regulation of B-cell growth in Helicobacter pylori–related gastric low-grade MALT lymphoma

Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment

Fludarabine‐containing chemotherapy as frontline treatment of nongastrointestinal mucosa‐associated lymphoid tissue lymphoma

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