Regressão da hepatosplenomegalia pelo tratamento específico da esquistossomose

Hepatosplenic schistosomiasis in field-based studies: a combined clinical and sonographic definition

“…Given enough time the disease may accordingly evolve into the severe form of schistosomiasis. It is also tempting to identify this group as the one which presents involution of the spleen after successful treatment with schistosomicides as shown by others (Bina & Prata 1983).…”

Angiogenesis and schistosomiasis

“…Data from human and experimental studies have revealed that in such situations hepatic fibrosis regresses, accompanied by a reduction in the spleen size, a drop in portal pressure and a reduction of oesophageal varices (Bina & Prata 1983, Dietze & Prata 1986, Homeida et al 1988, Mohamed-Ali et al 1991, Richter 2003. In that way, it may be assumed that not only has hepatic fibrosis been degraded and reduced, but that a considerable degree of intra-hepatic vascular remodelling has also occurred.…”

Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis

“…Clinical (Bina & Prata 1983, Dietze & Prata 1986, Homeida et al 1988, Mohamed-Ali et al 1991) and pathological (Andrade et al 1992) observations revealed that a proportion of patients with hepatosplenomegaly and portal hypertension due to Schistosoma mansoni infection, the so-called hepatosplenic schistosomiasis, could revert to normal, months or years after specific treatment. An instance of spontaneous regression of hepatosplenic schistosomiasis has even been observed in an isolated endemic area from the state of Minas Gerais, Brazil, probably due to the self-extinction of parasitism (Katz & Brener 1966).…”