Angiogenesis and schistosomiasis

Andrade, Zilton A.; Santana, Thaynã Souto

doi:10.1590/s0074-02762010000400013

Cited by 22 publications

(22 citation statements)

References 24 publications

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“…Apparently FCA alone had no specific role in our vaccination experiment, as emphasized by our results (Fig. 18) and as explained by Andrade and Santana [64] . The investigators reported that vascular proliferation can be observed throughout the early periovular granuloma formation, to be gradually displaced toward its periphery ending by forming of a surrounding vascular collar, while its center may appear almost avascular.…”

Section: Groups Central Vein Congestion Hepatic Sinusoids Congestion supporting

confidence: 56%

Modelling approaches to predict and evaluate schistosomiasis immunization utilizing SEA loaded on chitosan nanoparticles via liver tissue differentiation and angiogenesis

Etewa

Al-Hoot

Sharaf

et al. 2019

Parasitologists United Journal

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Schistosomiasis is caused by blood flukes including all Schistosoma species. It affects about 207 million persons in 76 countries across the world, and is more prevalent in developing countries where about 800 million people are at the risk of schistosomiasis [1]. Following oviposition, schistosomes eggs that failed to exit with either urine or stools are carried back into the liver to be lodged in the pre-sinusoidal capillaries. The eggs are in intimate contact with the capillary endothelium before and during the generation of the granulomatous response [2]. Schistosoma miracidium inside the ovum secretes glycoprotein antigens that pass through microscopic pores within the egg shell, so are called SEA. These antigens elicit a vigorous immune response that encapsulates the ova in pre-granuloma collagen fibers and immune cells, predominantly eosinophils and macrophages. The granuloma formation presents a barrier to sequester egg toxicity and antigenicity. Fibrosis of granulation tissues leads to disturbance of hepatic parenchymal architecture including its vasculature [3]. Despite portal vascular impairment, it was found that the total hepatic blood flow remained within normal limits with normal parenchymal cell perfusion, accompanied by absent gross changes in hepatic function tests. This was attributed to hepatic neovascular formation in the

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Section: Groups Central Vein Congestion Hepatic Sinusoids Congestion supporting

confidence: 56%

Modelling approaches to predict and evaluate schistosomiasis immunization utilizing SEA loaded on chitosan nanoparticles via liver tissue differentiation and angiogenesis

Etewa

Al-Hoot

Sharaf

et al. 2019

Parasitologists United Journal

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“…Recent experimental studies indicate that blood vessel proliferation in S. mansoni not only accompanies hepatic fibrogenesis, but possibly also regression of fibrosis after treatment [29]. To our knowledge, there have been no studies on S. haematobium and blood vessel proliferation.…”

Section: Discussionmentioning

confidence: 99%

Increased Vascularity in Cervicovaginal Mucosa with Schistosoma haematobium Infection

et al. 2011

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BackgroundClose to 800 million people in the world are at risk of schistosomiasis, 85 per cent of whom live in Africa. Recent studies have indicated that female genital schistosomiasis might increase the risk of human immunodeficiency virus (HIV) infection. The aim of this study is to quantify and analyse the characteristics of the vasculature surrounding Schistosoma haematobium ova in the female genital mucosa.Methodology/Principal FindingsCervicovaginal biopsies with S. haematobium ova (n = 20) and control biopsies (n = 69) were stained with immunohistochemical blood vessel markers CD31 and von Willebrand Factor (vWF), which stain endothelial cells in capillary buds and established blood vessels respectively. Haematoxylin and eosin (HE) were applied for histopathological assessment. The tissue surrounding S. haematobium ova had a higher density of established blood vessels stained by vWF compared to healthy controls (p = 0.017). Immunostain to CD31 identified significantly more granulation tissue surrounding viable compared to calcified ova (p = 0.032), and a tendency to neovascularisation in the tissue surrounding viable ova compared to healthy cervical mucosa (p = 0.052).Conclusions/SignificanceIn this study female genital mucosa with S. haematobium ova was significantly more vascularised compared to healthy cervical tissue. Viable parasite ova were associated with granulation tissue rich in sprouting blood vessels. Although the findings of blood vessel proliferation in this study may be a step to better understand the implications of S. haematobium infection, further studies are needed to explore the biological, clinical and epidemiological features of female genital schistosomiasis and its possible influence on HIV susceptibility.

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“…The animal model of liver fibrosis induced by CCl 4 showed morphologic and pathophysiologic aspects similar to human liver fibrosis. Moreover, the breeding of rats was simple, the modeling in rats was easy, the time cost was low, and the pathological features were stable and reliable [26, 27]. The animal modeling of liver fibrosis using CCl 4 includes intragastric administration via the mouth, intraperitoneal injection, and subcutaneous injection [28–30].…”

Section: Discussionmentioning

confidence: 99%

Establishment of a Standardized Liver Fibrosis Model with Different Pathological Stages in Rats

et al. 2012

Gastroenterology Research and Practice

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Objective. To establish a standardized animal model for liver fibrosis with the same assessment criteria for liver fibrosis studies that have been established on a unified platform. Methods. The standardized liver fibrosis model was established using Sprague-Dawley (SD) rats that either received an intraperitoneal injection of carbon tetrachloride (CCl4) in small dosages or ingested an ethanol solution. Results. The definite corresponding rules among modeling of different weeks and corresponding serology indices as well as different pathological staging can be observed by modeling with small dosages and slow, individualized, and combined administrations. Conclusion. This method can be used for the standardized establishment of a liver fibrosis model in rats across 5 pathological stages, ranging from S0 to S4, with a high success rate (89.33%) and low death rate (17.3%) because of the application of multiple hypotoxic chemicals for modeling. We refer to the criteria of Histological Grading and Staging of Chronic Hepatitis for Fibrosis established by the 10th World Digestive Disease Academic Conference in Los Angeles in September 1994 (revised in November 2000).

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Angiogenesis and schistosomiasis

Cited by 22 publications

References 24 publications

Modelling approaches to predict and evaluate schistosomiasis immunization utilizing SEA loaded on chitosan nanoparticles via liver tissue differentiation and angiogenesis

Modelling approaches to predict and evaluate schistosomiasis immunization utilizing SEA loaded on chitosan nanoparticles via liver tissue differentiation and angiogenesis

Increased Vascularity in Cervicovaginal Mucosa with Schistosoma haematobium Infection

Establishment of a Standardized Liver Fibrosis Model with Different Pathological Stages in Rats

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