GrainGenes (http://wheat.pw.usda.gov) is an international database for genetic and genomic information about Triticeae species (wheat [Triticum aestivum], barley [Hordeum vulgare], rye [Secale cereale], and their wild relatives) and oat (Avena sativa) and its wild relatives. A major strength of the GrainGenes project is the interaction of the curators with database users in the research community, placing GrainGenes as both a data repository and information hub. The primary intensively curated data classes are genetic and physical maps, probes used for mapping, classical genes, quantitative trait loci, and contact information for Triticeae and oat scientists. Curation of these classes involves important contributions from the GrainGenes community, both as primary data sources and reviewers of published data. Other partially automated data classes include literature references, sequences, and links to other databases. Beyond the GrainGenes database per se, the Web site incorporates other more specific databases, informational topics, and downloadable files. For example, unique BLAST datasets of sequences applicable to Triticeae research include mapped wheat expressed sequence tags, expressed sequence tag-derived simple sequence repeats, and repetitive sequences. In 2004, the GrainGenes project migrated from the AceDB database and separate Web site to an integrated relational database and Internet resource, a major step forward in database delivery. The process of this migration and its impacts on database curation and maintenance are described, and a perspective on how a genomic database can expedite research and crop improvement is provided. ) and oat (Avena sativa) crops to plant breeders, pathologists, geneticists, and molecular biologists (Matthews et al., 2003). Originally conceived as a stand-alone database, GrainGenes now encompasses an integrated database and Web site, working intensively with the smallgrains research community to provide an Internet portal for numerous ancillary projects for Triticeae genetics and contributing to the development of informatics tools to support small-grains research. Like many other organism-focused databases, GrainGenes concentrates on genomic aspects; however, it is also an important repository for information concerning genetic resources, pathology, and colleagues.The GrainGenes Database initially was operated using AceDB (http://www.acedb.org), a platform adopted by many early genome projects. AceDB served the GrainGenes project's needs very well with powerful schema, query languages, graphical displays, and the simplicity to be operated completely by a single biologist. The object-like data structures of AceDB worked well for handling the diverse underlying data, enabling straightforward connections between all data types and allowing the schema to be changed easily to accommodate new kinds of data. The AceDB software continued to develop and improve for several years and still has an active user community, providing an excellent resource for biological database deve...