Registers of psoriatic arthritis. Literature review

Koltakova, Anastasia

doi:10.14412/1995-4484-2019-210-217

Naučno-praktičeskaâ revmatologiâ

2019

DOI: 10.14412/1995-4484-2019-210-217

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Registers of psoriatic arthritis. Literature review

Anastasia Koltakova¹

Abstract: Observational cohort investigations are an effective way to study chronic diseases, including psoriatic arthritis, in clinical practice. One of the tools to support such research is registers that collect data related to various aspects of the disease and pharmacotherapy. This review provides information on the main registers of patients with psoriatic arthritis.

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Cited by 2 publications

References 66 publications

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Can the development of psoriatic arthritis be prevented in patients with psoriasis?

Насонов

Коротаева²,

Лила³

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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Psoriatic arthritis (PsA) is a chronic immunoinflammatory disease that, on the one hand, is considered as the most common comorbidity in psoriasis as part of systemic psoriatic disease, and, on the other, is classified as a clinical form of spondyloarthritis and lies at the interface of the basic problems of rheumatology and dermatology. The study of the evolution of psoriasis in relation to the development of PsA is a research priority area in rheumatology and dermatology, which is important for deciphering the nature of heterogeneity and the immunopathogenesis mechanisms of these diseases and for developing novel methods of personalized therapy at different stages of diseases.

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Can the development of psoriatic arthritis be prevented in patients with psoriasis?

Насонов

Коротаева²,

Лила³

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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Pathogenesis of Autonomic and Peripheral Neuropathy in Patients With Psoriasis

Машина

Нестеров

Belova

2023

Ulyanovsk Medico-biological Journal

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There is enough data confirming the common mechanisms of damage to the nervous system and skin in psoriasis. Cardiac autonomic denervation is a mechanism of cardiovascular pathology in psoriasis. Thus, a simultaneous disturbance of sympathetic and parasympathetic impact on vascular tone and heart rhythm has been established. When performing an active orthotest in trial subjects, heart rate centralization and decreased autonomous circuit activity were found. In psoriasis, vegetative-vascular dystonia develops due to metabolic disorders that occur in diabetes mellitus. Inflammatory cytokines Th-1, adhesion molecules, and angiogenic factors are involved in pathological processes in obesity, diabetes, metabolic syndrome, and thrombotic complications. Microangiopathy, which develops in psoriasis, reduces the response of blood vessels to autonomic innervation. Such negative influences eventually lead to a persistent alteration of the autonomic nervous control. The authors resent the results of a few studies on the peripheral nervous system in patients with psoriasis. There is evidence of a symmetrical alteration of vibration, tactile, pain and temperature sensitivity in the distal regions of all four limbs. There are some histological studies of the sural nerve in patients with psoriasis, which indicate demyelination of nerve fibers. In this regard, the study of neuropathy pathogenesis in psoriasis is necessary to improve the disease course and the effectiveness of psoriasis therapy. Assessment of psoriatic lesion severity and timely detection of cardiac denervation will reduce the risk of fatal cardiovascular complications. Instrumental diagnostics of the peripheral nervous system will make it possible to differentiate damage to muscle and nerve fibers in psoriasis.

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Registers of psoriatic arthritis. Literature review

Cited by 2 publications

References 66 publications

Can the development of psoriatic arthritis be prevented in patients with psoriasis?

Can the development of psoriatic arthritis be prevented in patients with psoriasis?

Pathogenesis of Autonomic and Peripheral Neuropathy in Patients With Psoriasis

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