1999
DOI: 10.1128/aem.65.12.5636-5638.1999
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Regiospecific Internal Desaturation of Aliphatic Compounds by a Mutant Rhodococcus Strain

Abstract: A mutant Rhodococcus strain lacking the ability to utilize 1-chlorohexadecane was found to cis-desaturate aliphatic compounds, such as 1-chlorohexadecane,n-hexadecane, and heptadecanonitrile, yielding corresponding products with a double bond mainly at the ninth carbon from the terminal methyl groups. A new oxidative pathway involving thecis-desaturation step was suggested for alkane utilization by Rhodococcus spp.

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Cited by 19 publications
(3 citation statements)
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“…These results suggest that sp. 008 uses hexadecane more e ciently than KSM B-3M through different metabolic pathways alluding that the mutation of the strain KSM B-3M potentially blocked subsequent alkane metabolism pathways 27 . To further identify the genes responsible for this transformation, we performed transcriptomic comparison between KSM B-3M and sp.…”
Section: Main Textmentioning
confidence: 99%
See 1 more Smart Citation
“…These results suggest that sp. 008 uses hexadecane more e ciently than KSM B-3M through different metabolic pathways alluding that the mutation of the strain KSM B-3M potentially blocked subsequent alkane metabolism pathways 27 . To further identify the genes responsible for this transformation, we performed transcriptomic comparison between KSM B-3M and sp.…”
Section: Main Textmentioning
confidence: 99%
“…The selective and e cient desaturation of linear saturated unfunctionalized hydrocarbons into their corresponding unsaturated products was missing as alkenes were never directly assessed as catabolic intermediates in alkane biodegradation. Crucially, a mutant strain of Rhodococcus (Rhodococcus KSM-B-3M) [26][27][28] , obtained through random mutagenesis of the wild type strain Rhodococcus KSM-B-3, could hyperproduce internal alkenes from linear alkanes in rather low yields. We were therefore interested to implement this original low-yielding transformation as a general approach and evaluate whether synthetically useful yields of alkenes could be obtained.…”
Section: Main Textmentioning
confidence: 99%
“…[39,40] The selective and efficient desaturation of linear saturated unfunctionalized hydrocarbons into their corresponding unsaturated products was missing as unfunctionalized alkenes were never directly assessed as catabolic intermediates in alkane biodegradation. Crucially, a mutant strain of the bacteria Rhodococcus (Rhodococcus KSM-B-3M), [41] obtained through random mutagenesis of the wild-type strain Rhodococcus KSM-B-3, was reported to hyperproduce internal alkenes from linear alkanes in a rather low yield (11 %). We were therefore interested to implement and improve this original low-yielding transformation as a general approach and evaluate whether synthetically useful yields of alkenes could be obtained.…”
mentioning
confidence: 99%