Regioselective Synthesis of Some Novel Pyrazoles, Isoxazoles, Pyrazolo[3,4‐d]pyridazines and Isoxazolo[3,4‐d]pyridazines Pendant to Benzimidazole.

Abstract

Me 2-Acetyl-1-methyl-1H-benzimidazole reacts with dimethylformamide-dimethyl-acetal (DMF-DMA) to afford the correspondingThe latter compound reacts regioselectively with some nitrilimines and nitrile oxides to afford the corresponding pyrazole and isoxazole derivatives, respectively. These reaction products react with hydrazine hydrate to give the novel pyrazolo [3,4-d]pyridazine and isoxazolo [3,4-d]pyridazine derivatives, respectively.