One-Pot Synthesis of Enaminones Using Golds Reagent

Saleh, Tamer S.; Al-Omar, Mohamed A.; Abdel‐Aziz, Hatem A.

doi:10.2174/157017810791824793

Cited by 16 publications

(5 citation statements)

References 17 publications

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“…Moreover, enaminones are motivating compounds not only for their pharmacological potentialities but also for being valuable intermediates for the synthesis of several heterocyclic systems .…”

Section: Introductionmentioning

confidence: 99%

Microwave‐assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Al‐Bogami

Mekky

2015

Journal of Heterocyclic Chem

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We introduce efficient regioselective synthesis of a series of novel bis(pyrazoles) and bis(isoxazoles) via 1,3‐dipolar cycloaddition reaction under microwave irradiation. Unequivocal structural assignment of the obtained regioisomers was determined utilizing 1H‐13C HMBC NMR techniques as a valuable tool. A comparative study of the aforementioned reactions was carried out under conventional method as well as under microwave irradiation conditions.

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Section: Introductionmentioning

confidence: 99%

Microwave‐assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Al‐Bogami

Mekky

2015

Journal of Heterocyclic Chem

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“…( E )-3-(dimethylamino)-1-arylprop-2-en-1-ones 4a–j ( Figure 1 ) were synthesized according to the reported method by Saleh et al [ 23 ] and crystallized from EtOH to enhance sample purity for analysis.…”

Section: Methodsmentioning

confidence: 99%

Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS³of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study

Kadi

Abdel‐Aziz

Angawi

et al. 2014

The Scientific World Journal

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A new approach was recently introduced to improve the structure elucidation power of tandem mass spectrometry simulating the MS3 of ion trap mass spectrometry system overcoming the different drawbacks of the latter. The fact that collision induced dissociation in the triple quadrupole mass spectrometer system provides richer fragment ions compared to those achieved in the ion trap mass spectrometer system utilizing resonance excitation. Moreover, extracting comprehensive spectra in the ion trap needs multistage fragmentation, whereas similar fragment ions may be acquired from one stage product ion scan using the triple quadrupole mass spectrometer. The new strategy was proven to enhance the qualitative performance of tandem mass spectrometry for structural elucidation of different chemical entities. In the current study we are endeavoring to prove our hypothesis of the efficiency of the new pseudo-MS3 technique via its comparison with the MS3 mode of ion trap mass spectrometry system. Ten pharmacologically and synthetically important (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones (enaminones 4a–j) were chosen as model compounds for this study. This strategy permitted rigorous identification of all fragment ions using triple quadrupole mass spectrometer with sufficient specificity. It can be used to elucidate structures of different unknown components. The data presented in this paper provide clear evidence that our new pseudo-MS3 may simulate the MS3 of ion trap spectrometry system.

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“…Obtained from 1-benzofuran-2-yl-3-(dimethylamino)-prop-2-en-1-one 27 (9) following the typical procedure as 3i. …”

Section: 123mentioning

confidence: 99%

Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties

Congiu

Onnis

Deplano

et al. 2015

Bioorganic & Medicinal Chemistry

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A series of sulfamates were synthesized using as lead compound SLC-0111, a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor in Phase I clinical trials. The new derivatives incorporated ureido moieties as spacers between the benzene sulfamate fragment which binds the zinc ion from the active site, and the tail of the inhibitor, but the urea moieties were part of a substituted piperazine ring system. The derivatives (and some of their phenol precursors) were tested for the inhibition of the cytosolic, hCA I and II (off target isoforms) and the trans-membrane, tumor-associated hCA IX and XII enzymes (anticancer drug targets). Generally hCA I was not effectively inhibited, whereas many low nanomolar inhibitors were evidenced against hCA II (KIs in the range of 1.0–94.4 nM), IX (KIs in the range of 0.91–36.9 nM), and XII (KIs in the range of 1.0–84.5 nM). The best substitution fragments at the piperazine ring included the following moieties: 3-methylphenyl, 2,3-dimethylphenyl, 4-methoxyphenyl, 6-arylpyrimidine-2-yl

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One-Pot Synthesis of Enaminones Using Golds Reagent

Cited by 16 publications

References 17 publications

Microwave‐assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Microwave‐assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS³of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study

Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties

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One-Pot Synthesis of Enaminones Using Golds Reagent

Cited by 16 publications

References 17 publications

Microwave‐assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Microwave‐assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS3of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study

Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties

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Product

Resources

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Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS³of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study