Regioselective synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds via transition metal-free C–C and C–N bond formation

Abstract

Few methods are known for the synthesis of nitroindole derivatives. A simple and practical Cs2CO3-promoted method for the synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds has been developed....

Indole frameworks via transition-metal-free annulation: a current perspective

“…Very recently, Ge et al recommended a practical protocol for 6-nitroindole derivatives 79 starting from easily accessible enaminones 78 and nitroaromatic compounds 77 . 82 The transformation was promoted by Cs 2 CO 3 in chlorobenzene solvent. A series of N -substituted-3-aminocyclohex-2-enones possessing electro-donating/withdrawing groups (Me, t Bu, OMe, OEt, F, Cl, CF 3 , etc. )…”

Regioselective synthesis of phenanthridine-fused quinazolinones using a 9-mesityl-10-methylacridinium perchlorate photocatalyst

“…So, the photochemical regioselective C–N cross-coupling reactions are of great interest in organic synthesis. 16…”