An efficient method for the synthesis of β,β-di(hetero)aryl-α,α-difluorinated ketones using readily available organophosphonium salts and difluoroenol silyl ethers has been developed. This mild reaction features a good functional group tolerance, a scaled-up synthesis, and synthetic simplicity. By taking advantage of DMSO as a less-toxic promoter and solvent for the difluoroalkylation and C−P bond functionalization, the use of transition-metal catalysts and sensitive additives could be avoided.

An efficient palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides was developed. The reactions proceeded smoothly in the presence of palladium catalyst, magnesium turnings, LiCl, and TMEDA in...

Transformation of multifunctional materials with control over site-selectivity and chemical diversity remains challenging. Herein, we present a metal-free, one-pot strategy for the defluorophosphorylation of polyfluoroalkyl peroxides that enables expedient construction...

An efficient defluorinative cyclization strategy for the construction of perfluoroalkyl-substituted pyrimidines by using perfluoroalkyl alkynes and amidines as substrates was developed.

A Selectfluor™-catalyzed oxidative cyclization of ynamides employing DMSO as the solvent and oxidant was achieved, affording oxazolidine-2,4-diones in moderate to excellent yields with high chemo-selectivity. The method offers an attractive alternative to existing protocols.