Regional Variations in Risk Factors for Asthma in School Children

Lawson, Joshua; Rennie, Donna; Cockcroft, Donald W.; McDuffie, Helen H.

doi:10.1155/2005/942637

Cited by 19 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taiwan is located in a subtropical climate zone, with high temperatures and humidity (monthly mean 68–80%). Home dampness is a common problem and an important environmental factor for asthma [46], [47], [48], [49]. However, few studies are concerned with the genetic modification effects of home dampness on childhood asthma [50].…”

Section: Discussionmentioning

confidence: 99%

Gene-Gene and Gene-Environmental Interactions of Childhood Asthma: A Multifactor Dimension Reduction Approach

Tung

Liang

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

BackgroundThe importance of gene-gene and gene-environment interactions on asthma is well documented in literature, but a systematic analysis on the interaction between various genetic and environmental factors is still lacking.Methodology/Principal FindingsWe conducted a population-based, case-control study comprised of seventh-grade children from 14 Taiwanese communities. A total of 235 asthmatic cases and 1,310 non-asthmatic controls were selected for DNA collection and genotyping. We examined the gene-gene and gene-environment interactions between 17 single-nucleotide polymorphisms in antioxidative, inflammatory and obesity-related genes, and childhood asthma. Environmental exposures and disease status were obtained from parental questionnaires. The model-free and non-parametrical multifactor dimensionality reduction (MDR) method was used for the analysis. A three-way gene-gene interaction was elucidated between the gene coding glutathione S-transferase P (GSTP1), the gene coding interleukin-4 receptor alpha chain (IL4Ra) and the gene coding insulin induced gene 2 (INSIG2) on the risk of lifetime asthma. The testing-balanced accuracy on asthma was 57.83% with a cross-validation consistency of 10 out of 10. The interaction of preterm birth and indoor dampness had the highest training-balanced accuracy at 59.09%. Indoor dampness also interacted with many genes, including IL13, beta-2 adrenergic receptor (ADRB2), signal transducer and activator of transcription 6 (STAT6). We also used likelihood ratio tests for interaction and chi-square tests to validate our results and all tests showed statistical significance.Conclusions/SignificanceThe results of this study suggest that GSTP1, INSIG2 and IL4Ra may influence the lifetime asthma susceptibility through gene-gene interactions in schoolchildren. Home dampness combined with each one of the genes STAT6, IL13 and ADRB2 could raise the asthma risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Gene-Gene and Gene-Environmental Interactions of Childhood Asthma: A Multifactor Dimension Reduction Approach

Tung

Liang

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Typical indoor pollutants have been associated with increased prevalence of asthma and allergy including formaldehyde [107–110], cleaning products [111], solvents [112–114], and moulds [115–118].…”

Section: Health Effects After Birthmentioning

confidence: 99%

Air pollution: A threat to the health of our children

Moshammer¹,

Bartoňová

Hanke

et al. 2006

Acta Paediatrica

View full text Add to dashboard Cite

Medical doctors have a responsibility to know the facts and to advise their patients. Doctors when visiting their patients' homes should be aware of the possibly grave impact of the indoor environment for the respiratory health of their patients. They should recognize and advise the parents on problems associated with environmental tobacco smoke, poor ventilation, mould growth, and maintenance of heating installations. With regard to outdoor air pollution, doctors could serve as role models and also advise their patients and parents on environmentally friendly behaviour. Such behaviour not only calls for personal commitment but also for the right infrastructure to be provided (e.g. public transport, district heating). Doctors should be proactive in the community and in their country as advocates for a healthier environment for our children.

show abstract

“…A similar result (33.9%) was obtained by Garcia-Ramos et al (1992) 19 in Spanish students with asthma. Other authors 20,21 have described a significant association between asthmatic subjects with a family history of asthma with asthma in school children. Asthma has a heritability rate Ͼ75% and involves a significant genetic component.…”

Section: Discussionmentioning

confidence: 96%

Lung function, asthma paradox, atopy, and risk factors in Mexican spirometry-diagnosed asthmatic patients

Recio-Vega

Gabriel

Sánchez-Cabral

et al. 2007

allergy asthma proc

View full text Add to dashboard Cite

Despite long-term studies, still not much is known about the asthma triggering factors and its sometimes controversial results. Probably one of the major problems of controversy is the lack of specific and accurate diagnosis of this disease. The aim of this study was to assess lung function, atopy, and environmental factors in spirometry-diagnosed asthmatic patients. Time series of daily counts of hospital emergency admissions were constructed for known asthmatic subjects. Spirometry, chest radiograph, arterial gasometry, skin tests, environmental SO2 levels, and climatic parameters were evaluated. Family asthma history was observed in a high proportion of asthmatic patients and it correlated marginally with severity of asthma. A seasonal trend in asthma frequency was recorded and it was more common in the urban area and in those living in the margins of the city. The most frequent asthma type recorded was the severe persistent asthma. More than 50% of subjects had subresponse to bronchodilator; asthma paradox was recorded in 10.8%. Positive skin tests were observed in 36.9% and SO2 levels did not correlate with asthma attacks. Paradox asthma or tolerance may be developed by asthmatic subjects during chronic treatment with short-acting 92-agonists. To avoid side effects and to decrease the morbidity and mortality associated with the usage of antiasthma medications, it is essential to identify quickly those subjects that respond abnormally to the short-acting P2-agonist.

show abstract

Regional Variations in Risk Factors for Asthma in School Children

Cited by 19 publications

References 29 publications

Gene-Gene and Gene-Environmental Interactions of Childhood Asthma: A Multifactor Dimension Reduction Approach

Gene-Gene and Gene-Environmental Interactions of Childhood Asthma: A Multifactor Dimension Reduction Approach

Air pollution: A threat to the health of our children

Lung function, asthma paradox, atopy, and risk factors in Mexican spirometry-diagnosed asthmatic patients

Contact Info

Product

Resources

About