Lung function, asthma paradox, atopy, and risk factors in Mexican spirometry-diagnosed asthmatic patients

Abstract

Despite long-term studies, still not much is known about the asthma triggering factors and its sometimes controversial results. Probably one of the major problems of controversy is the lack of specific and accurate diagnosis of this disease. The aim of this study was to assess lung function, atopy, and environmental factors in spirometry-diagnosed asthmatic patients. Time series of daily counts of hospital emergency admissions were constructed for known asthmatic subjects. Spirometry, chest radiograph, arterial gasometry, skin tests, environmental SO2 levels, and climatic parameters were evaluated. Family asthma history was observed in a high proportion of asthmatic patients and it correlated marginally with severity of asthma. A seasonal trend in asthma frequency was recorded and it was more common in the urban area and in those living in the margins of the city. The most frequent asthma type recorded was the severe persistent asthma. More than 50% of subjects had subresponse to bronchodilator; asthma paradox was recorded in 10.8%. Positive skin tests were observed in 36.9% and SO2 levels did not correlate with asthma attacks. Paradox asthma or tolerance may be developed by asthmatic subjects during chronic treatment with short-acting 92-agonists. To avoid side effects and to decrease the morbidity and mortality associated with the usage of antiasthma medications, it is essential to identify quickly those subjects that respond abnormally to the short-acting P2-agonist.

Disparities in allergy testing and health outcomes among urban children with asthma

“…For example, research done by Recio-Vega et al 20 in Mexico found that more than one third of patients with newly diagnosed asthma had a positive allergy skin test response. 20 Our study showed that less than 15% of Mexican American children had received an allergy diagnosis, despite research that shows Mexican Americans have a higher prevalence of both asthma and hay fever than their counterparts living in Mexico. 21 Our results show children who used a physician's office as their usual source of care were more likely to respond that they were given a diagnosis of allergy than children using other sources of care.…”