Regional myocardial layer function in Doxorubicin cardiomyopathy; clinical evaluation using novel ultrasonic Doppler method

Koiwa, Yoshiro; Kamada, Hiroki; Kanai, Hiroshi; Sugimura, K.; Tezuka, Fumiaki; Saitoh, Yoshiko; Honda, Hiroaki; Shirato, Kunio; Chubachi, Noriyoshi

doi:10.1109/ultsym.1998.765218

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The principle of the high resolution Doppler method "the Phased Tracking Method" including the theoretical, in-vitro and in-vivo evaluations for the myocardial layer thickening and thickening rate was described elsewhere and the firm relation to the myocardial histology was also described elsewhere [5] [6]. In brief, RF pulses with an angular frequency of ω 0 = 2πf 0 are transmitted at a time interval of ∆T from an ultrasonic transducer on the chest wall.…”

Section: Methodsmentioning

confidence: 99%

Magnitude of transmural heterogeneity as a dominant factor for LVEDP elevation in HCM

Koiwa

Kamada²,

Ikeda³

et al.

2001 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.01CH37263)

Self Cite

View full text Add to dashboard Cite

Using the Phased Tracking Method (Doppler frequency: 3 MHz, PRF: 9 kHz), we examined the transmural response to mitral inflow in ten hypertrophic cardiomyopathy (HCM) patients to determine if transmural physical heterogeneity could be a determinant factor of the left ventricular end-diastolic pressure (LVEDP) elevation in HCM. In normal and AS patients, no heterogeneity in the transmural response of the vertical velocity at each preset point (0.75mm-intervals in depth) and the change in each transmural layer thickness across the septum to the mitral inflow was observed. In HCM, the magnitude and the timing of the velocity at each preset point showed remarkable variation among myocardial layers across the septum. The "passive thickening" by atrial inflow was observed at several layers by these temporal and amplitude heterogeneities of transmural velocity distribution. The % of layers showing "passive thickness" during the atrial contraction period was strongly correlated to LVEDP. We concluded that the transmural heterogeneity plays an important role in the LVEDP elevation in HCM patients.

show abstract

Section: Methodsmentioning

confidence: 99%