Importance of regional myocardial layer function by phased tracking method in doxorubicin cardiomyopathy

Koiwa, Yoshiro; Kamada, Hiroki; Shirato, Kunio; Saitoh, Yoshiko; Kanai, Hiroshi

doi:10.1109/ultsym.1999.849243

Cited by 3 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The principle of the high resolution Doppler method "the Phased Tracking Method" including the theoretical, in-vitro and in-vivo evaluations for the myocardial layer thickening and thickening rate was described elsewhere and the firm relation to the myocardial histology was also described elsewhere [5] [6]. In brief, RF pulses with an angular frequency of ω 0 = 2πf 0 are transmitted at a time interval of ∆T from an ultrasonic transducer on the chest wall.…”

Section: Methodsmentioning

confidence: 99%

Magnitude of transmural heterogeneity as a dominant factor for LVEDP elevation in HCM

Koiwa

Kamada²,

Ikeda³

et al.

2001 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.01CH37263)

Self Cite

View full text Add to dashboard Cite

Using the Phased Tracking Method (Doppler frequency: 3 MHz, PRF: 9 kHz), we examined the transmural response to mitral inflow in ten hypertrophic cardiomyopathy (HCM) patients to determine if transmural physical heterogeneity could be a determinant factor of the left ventricular end-diastolic pressure (LVEDP) elevation in HCM. In normal and AS patients, no heterogeneity in the transmural response of the vertical velocity at each preset point (0.75mm-intervals in depth) and the change in each transmural layer thickness across the septum to the mitral inflow was observed. In HCM, the magnitude and the timing of the velocity at each preset point showed remarkable variation among myocardial layers across the septum. The "passive thickening" by atrial inflow was observed at several layers by these temporal and amplitude heterogeneities of transmural velocity distribution. The % of layers showing "passive thickness" during the atrial contraction period was strongly correlated to LVEDP. We concluded that the transmural heterogeneity plays an important role in the LVEDP elevation in HCM patients.

show abstract

Section: Methodsmentioning

confidence: 99%

Magnitude of transmural heterogeneity as a dominant factor for LVEDP elevation in HCM

Koiwa

Kamada²,

Ikeda³

et al.

2001 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.01CH37263)

Self Cite

View full text Add to dashboard Cite

show abstract

The distortion from the physiological profile of the transmural systolic function of the myocardium in doxorubicin cardiomyopathy

Koiwa

Shirato

Saitoh

et al.

2002 IEEE Ultrasonics Symposium, 2002. Proceedings.

View full text Add to dashboard Cite

Systolic Heterogeneity of Transmural Myocardial Function in Normal Subjects: Physiological Functional Heterogeneity.

Koiwa

Kamada

Inose

et al. 2002

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Because of the lack of a clinical method for assessing the transmural myocardial function, few studies on the heterogeneity during the myocardial contraction/relaxation sequence inside the human ventricular wall have been reported, despite the fact that the importance of the pathophysiology in the transmural heterogeneity has been stressed in previous experimental studies. We studied the transmyocardial functional heterogeneity of the basal anteroseptal segment in normal subjects (n = 8, 40.0 +/- 12.8 year, male), adopting the novel high resolution Doppler measurement "Phased Tracking Method". Each transmural layer of 0.75 mm thickness showed functional heterogeneity (physiological transmural functional heterogeneity), namely larger thickening occurred in the left ventricular endocardial side (right side 1/3: 26.1 +/- 5.2% of the total wall thickness, middle 1/3: 31.9 +/- 2.7%, left side 1/3: 42.1 +/- 6.4%) and the peak thickening shifted smoothly in time from the middle layers to the left subendocardial side during the contraction period. We concluded that transmural functional heterogeneity does exist in normal subjects as well as in the experimental animals of previous reports. Smooth and coordinate myocardial layer contraction across the ventricular wall (physiological transmural functional heterogeneity) is fundamental to maintain the normal ventricular function.

show abstract

Importance of regional myocardial layer function by phased tracking method in doxorubicin cardiomyopathy

Cited by 3 publications

References 11 publications

Magnitude of transmural heterogeneity as a dominant factor for LVEDP elevation in HCM

Magnitude of transmural heterogeneity as a dominant factor for LVEDP elevation in HCM

The distortion from the physiological profile of the transmural systolic function of the myocardium in doxorubicin cardiomyopathy

Systolic Heterogeneity of Transmural Myocardial Function in Normal Subjects: Physiological Functional Heterogeneity.

Contact Info

Product

Resources

About