Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice

Monzem, Samuel; Valkani, Dionysia; Evans, Lucinda; Chang, Yu‐Mei; Pitsillides, Andrew A.

doi:10.1016/j.bone.2023.116720

Cited by 1 publication

(2 citation statements)

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“…In particular, our findings revealed highly‐region dependent adaptations, with an increased benefit from combined treatment with loading and PTH to the posterior‐lateral region of the mid‐diaphyseal bone 16 . Recently, a cross‐sectional study on C57BL/6 (not OVX) mice showed that the bone anabolic response to a combination of mechanical loading and PTH depends on the dose and regimen of the intervention and that it affects differently the trabecular and cortical compartments, highlighting the potential of the combined biomechanical and pharmacological treatment 27 . Nevertheless, in those studies it was not investigated how the bone anabolic effects would affect the mechanical properties of the bone at early or later stages of treatments.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a cross-sectional study on C57BL/6 (not OVX) mice showed that the bone anabolic response to a combination of mechanical loading and PTH depends on the dose and regimen of the intervention and that it affects differently the trabecular and cortical compartments, highlighting the potential of the combined biomechanical and pharmacological treatment. 27 Nevertheless, in those studies it was not investigated how the bone anabolic effects would affect the mechanical properties of the bone at early or later stages of treatments. To our knowledge, no study has evaluated yet the combined longitudinal effects of PTH and loading on tibia bone mechanics in an ovariectomised mouse model of OP.…”

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confidence: 99%

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Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice

Roberts,

Cheong,

Oliviero

et al. 2024

Journal Orthopaedic Research

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Combined treatment with PTH(1‐34) and mechanical loading confers increased structural benefits to bone than monotherapies. However, it remains unclear how this longitudinal adaptation affects the bone mechanics. This study quantified the individual and combined longitudinal effects of PTH(1‐34) and mechanical loading on the bone stiffness and strengthe evaluated in vivo with validated micro‐finite element (microFE) models. C57BL/6 mice were ovariectomised at 14‐weeks‐old and treated either with injections of PTH(1‐34), compressive tibia loading or both interventions concurrently. Right tibiae were in vivo microCT‐scanned every two weeks from 14 until 24‐weeks‐old. MicroCT images were rigidly registered to reference tibia and the cortical organ (whole bone) and tissue‐level (midshaft) morphometric properties and bone mineral content were quantified. MicroCT images were converted into voxel‐based homogeneous, linear elastic microFE models to estimate the bone stiffness and strength. This approach allowed us for the first time to quantify the longitudinal changes in mechanical properties induced by combined treatments in a model of accelerated bone resorption. Both changes of stiffness and strength were higher with co‐treatment than with individual therapies, consistent with increased benefits with the tibia bone mineral content and cortical area – properties strongly associated with the tibia mechanics. The longitudinal data shows thatthe two bone anabolics, both individually and combined, had persistent benefit on estimated mechanical properties, and that benefits (increased stiffness and strength) remained after treatment was withdrawn.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%