Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson's model rats

Carlson, Jonathan D.; Pearlstein, Robert D.; Buchholz, John N.; Iacono, Robert P.; Maeda, G.

doi:10.1016/s0006-8993(99)01268-8

Cited by 37 publications

(25 citation statements)

References 44 publications

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“…This was hypothesized to indicate that outflow from the pallidum had become disinhibited, leading to GABAmediated inhibition of the PPTg. Strikingly similar data were obtained by Jonathan Carlson and his colleagues [222] using the 6-OHDA rat model of Parkinsonism.…”

Section: The Pptg and Parkinson's Diseasesupporting

confidence: 82%

How best to consider the structure and function of the pedunculopontine tegmental nucleus: Evidence from animal studies

Winn

2006

Journal of the Neurological Sciences

161

138

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Section: The Pptg and Parkinson's Diseasesupporting

confidence: 82%

How best to consider the structure and function of the pedunculopontine tegmental nucleus: Evidence from animal studies

Winn

2006

Journal of the Neurological Sciences

161

138

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“…For instance, whereas unilateral or bilateral PPN lesions in control monkeys caused either transient hemi-akinesia or a long-lasting akinetic effect, respectively (Kojima et al 1997;Aziz et al 1998;Munro-Davis et al 1999), DBS of the PPN in MPTP-treated monkeys improved akinesia (Jenkinson et al 2004). Nevertheless, it is worth noting that a number of studies have clearly demonstrated the presence of bilateral hyperactivity of the PPN following unilateral nigrostriatal damage in rodents (Carlson et al 1999;Breit et al 2001Breit et al , 2008, ultimately leading to enhanced glutamate release arising from the PPN (Blanco-Lezcano et al 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Unilateral lesions of the PPN resulted in transient hemiakinesia in normal monkeys, whereas a severe, longlasting akinetic effect was noticed following bilateral PPN lesions (Kojima et al 1997;Aziz et al 1998;MunroDavis et al 1999). Futhermore, bilateral PPN hyperactivity was reported in rats with unilateral nigrostriatal damage (Carlson et al 1999;Breit et al 2001Breit et al , 2008 together with an increased number of cholinergic neurons (García-Rill et al 1995) and augmented release of glutamate (Blanco-Lezcano et al 2005). These data paved the way for appointing the PPN nucleus as a potential surgical candidate for functional neurosurgery (Jenkinson et al 2005;Plaha and Gill 2005;Breit et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Glutamatergic and cholinergic pedunculopontine neurons innervate the thalamic parafascicular nucleus in rats: changes following experimental parkinsonism

et al. 2011

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The tegmental pedunculopontine nucleus (PPN) is a basal ganglia-related structure that has recently gained renewed interest as a potential surgical target for the treatment of several aspects of Parkinson's disease. However, the underlying anatomical substrates sustaining the choice of the PPN nucleus as a surgical candidate remain poorly understood. Here, we characterized the chemical phenotypes of different subtypes of PPN efferent neurons innervating the rat parafascicular (PF) nucleus. Emphasis was placed on elucidating the impact of unilateral nigrostriatal denervation on the expression patterns of the mRNA coding the vesicular glutamate transporter type 2 (vGlut2 mRNA). We found a bilateral projection from the PPN nucleus to the PF nucleus arising from cholinergic and glutamatergic efferent neurons, with a small fraction of projection neurons co-expressing both cholinergic and glutamatergic markers. Furthermore, the unilateral nigrostriatal depletion induced a bilateral twofold increase in the expression levels of vGlut2 mRNA within the PPN nucleus. Our results support the view that heterogeneous chemical profiles account for PPN efferent neurons innervating thalamic targets. Moreover, a bilateral enhancement of glutamatergic transmission arising from the PPN nucleus occurs following unilateral dopaminergic denervation, therefore sustaining the well-known hyperactivity of the PF nucleus in parkinsonian-like conditions. In conclusion, our data suggest that the ascending projections from the PPN that reach basal ganglia-related targets could play an important role in the pathophysiology of Parkinson's disease.

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“…For the zona incerta and pedunculopontine nucleus, CO mRNA expression (Pe`rier et al 2000;Orieux et al 2000), 2-deoxyglucose uptake (Mitchell et al 1989;Carlson et al 1999) and electrical activity (Pe`rier et al 2000;Breit et al 2001) have been reported to be increased in either 6OHDA-lesioned rats or MPTPtreated monkeys. This overactivity is not evident in the present study; in both nuclei, we show no major change in the number of strongly labelled Fos + cells in 6OHDA-lesioned rats compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Fos immunoreactivity in some locomotor neural centres of 6OHDA-lesioned rats

Heise

Mitrofanis

2006

Anat Embryol

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In this study, we explore Fos expression (a measure of cell activity) in three nuclei associated with locomotion, namely the zona incerta, pedunculopontine tegmental nucleus and cuneiform nucleus (the latter two form the mesencephalic locomotor region) in hemiparkinsonian rats. Sprague-Dawley rats had small volumes of either saline (control) or 6 hydroxydopamine (6OHDA) injected into the medial forebrain bundle, the major tract carrying dopaminergic nigrostriatal axons. After various post-lesion survival periods, ranging from 2 h to 28 days, rats were perfused with formaldehyde and their brains processed for routine tyrosine hydroxylase and Fos immunocytochemistry. Our results showed a significant increase (P < 0.05) in the number of strongly labelled Fos+ cells in the cuneiform nucleus in the 6OHDA-lesioned cases compared to the controls after 7 and 28 days survival periods. By contrast, there were no significant differences (P > 0.05) in the number of strong-labelled Fos+ cells in the zona incerta and pedunculopontine nucleus of 6OHDA-lesioned rats compared to controls at any survival period. Many of the Fos+ cells within the pedunculopontine and cuneiform nuclei were glutamatergic (35-60%), while none or very few were nitric oxide synthase+. In conclusion, we reveal an increase in the number of strongly labelled Fos+ cells within the cuneiform nucleus of the so-called defensive locomotive system in 6OHDA-lesioned rats. In relation to Parkinson disease, we suggest that this increase is associated with the akinesia or lack of movement seen in patients.

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Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson's model rats

Cited by 37 publications

References 44 publications

How best to consider the structure and function of the pedunculopontine tegmental nucleus: Evidence from animal studies

How best to consider the structure and function of the pedunculopontine tegmental nucleus: Evidence from animal studies

Glutamatergic and cholinergic pedunculopontine neurons innervate the thalamic parafascicular nucleus in rats: changes following experimental parkinsonism

Fos immunoreactivity in some locomotor neural centres of 6OHDA-lesioned rats

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