Regional glucose metabolism and histopathology of gliomas: A study based on positron emission tomography-guided stereotactic biopsy

Abstract

FDG uptake in gliomas is anatomically heterogeneous and is regionally related to the presence of anaplasia.

Diagnostic and Prognostic Value of11C-Methionine PET for Nonenhancing Gliomas

“…8,[16][17][18][19][20][21][22][23] On the other hand, MET PET was first reported in 1983 by Bergström et al 24 as a useful imaging technique to delineate glioma. Because MET PET has a low normal cortical uptake and high uptake in gliomas, this method has been considered superior to FDG-PET for delineation of the lesion.…”

Positron emission tomography11C-methionine and survival in patients with low-grade gliomas

“…13 The method has been used in guiding stereotactic biopsies, 14 for evaluation of response to therapy, 15,16 and also in differentiating between low-grade tumors and nontumor lesions. 17 Some authors claim that the uptake of 18 Ffluorodeoxyglucose (FDG) is a prognostic factor in patients with low-grade gliomas, 18,19 although the patient populations in those studies were too small to allow multivariate survival analysis.…”

1-11C-Acetate Versus 18F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery

“…Obviously, loss of 11 C through decarboxylation reactions did not defer the detection of meningioma by PET. Although carbons in position 2 of acetyl-CoA are more likely directed toward gluconeogenesis and incorporation into glutamine (34), glutamine isotopic enrichment is slightly but not significantly higher when 1-13 C-acetate is infused, versus 2-13 C-acetate (35). These findings may support the adequacy of the use of 1-11 C-acetate as a PET agent for detecting meningiomas.…”