1-<sup>11</sup>C-Acetate Versus <sup>18</sup>F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery

Liu, Ru‐Shi; Chang, Chen Pei; Guo, Wen; Pan, David Hung Chi; Ho, Donald Ming Tak; Chang, Chi Wei; Yang, Bohan; Wu, Liang; Yeh, S. H.

doi:10.2967/jnumed.109.070565

Cited by 50 publications

(24 citation statements)

References 39 publications

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“…However, 1-11C-acetate was not found to be useful for evaluating the tumor grade (69). 18F-FDG is found to be of lower worth than both membrane biosynthesis markers for evaluating the extent of meningiomas and the response to surgical treatment, but 18F-FDG may be useful for differentiating benign from malignant meningiomas (69)(70).…”

Section: Meningiomasmentioning

confidence: 88%

“…18F-FDG is found to be of lower worth than both membrane biosynthesis markers for evaluating the extent of meningiomas and the response to surgical treatment, but 18F-FDG may be useful for differentiating benign from malignant meningiomas (69)(70). 18F-FDG and 1-11C-acetate are complementary for assessing diverse cell metabolism of meningiomas (69).…”

Section: Meningiomasmentioning

confidence: 97%

“…1-11C-acetate and 11C-choline were found to be useful for detecting meningiomas and evaluating the extent of meningiomas and are potentially useful for monitoring tumor response to surgery (69)(70).…”

Section: Meningiomasmentioning

confidence: 99%

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Current Molecular Imaging of Spinal Tumors in Clinical Practice

Sandu

Pöpperl²,

Toubert

et al. 2011

Mol Med

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Energy metabolism measurements in spinal cord tumors, as well as in osseous spinal tumors/metastasis in vivo, are rarely performed only with molecular imaging (MI) by positron emission tomography (PET). This imaging modality developed from a small number of basic clinical science investigations followed by subsequent work that influenced and enhanced the research of others. Apart from precise anatomical localization by coregistration of morphological imaging and quantification, the most intriguing advantage of this imaging is the opportunity to investigate the time course (dynamics) of disease-specific molecular events in the intact organism. Most importantly, MI represents one of the key technologies in translational molecular neuroscience research, helping to develop experimental protocols that may later be applied to human patients. PET may help monitor a patient at the vertebral level after surgery and during adjuvant treatment for recurrent or progressive disease. Common clinical indications for MI of primary or secondary CNS spinal tumors are: (i) tumor diagnosis, (ii) identification of the metabolically active tumor compartments (differentiation of viable tumor tissue from necrosis) and (iii) prediction of treatment response by measurement of tumor perfusion or ischemia. While spinal PET has been used under specific circumstances, a question remains as to whether the magnitude of biochemical alterations observed by MI in CNS tumors in general (specifically spinal tumors) can reveal any prognostic value with respect to survival. MI may be able to better identify early disease and to differentiate benign from malignant lesions than more traditional methods. Moreover, an adequate identification of treatment effectiveness may influence patient management. MI probes could be developed to image the function of targets without disturbing them or as treatment to modify the target's function. MI therefore closes the gap between in vitro and in vivo integrative biology of disease. At the spinal level, MI may help to detect progression or recurrence of metastatic disease after surgical treatment. In cases of nonsurgical treatments such as chemo-, hormone-or radiotherapy, it may better assess biological efficiency than conventional imaging modalities coupled with blood tumor markers. In fact, PET provides a unique possibility to correlate topography and specific metabolic activity, but it requires additional clinical and experimental experience and research to find new indications for primary or secondary spinal tumors.

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Section: Meningiomasmentioning

confidence: 88%

Section: Meningiomasmentioning

confidence: 97%

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Current Molecular Imaging of Spinal Tumors in Clinical Practice

Sandu

Pöpperl²,

Toubert

et al. 2011

Mol Med

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“…Alternatively, a number of different PET tracers can be used to visualize the geometry of meningiomas for improved target volume definition, such as [ 18 (5,11), [ 11 C]acetate (12), [ 11 C]choline (13,14), or [ 11 C]methionine (15).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous 68Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience

Thorwarth

Henke

Müller

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…For example, in a case of recurrent glioblastoma multiforme, ambiguously enhanced lesion on magnetic resonance imaging was suggested to be highly malignant area, because the coregistered FDG-PET showed high uptake at the corresponding area, and this region was irradiated. As another example, 1-11C-acetate PET was utilized for evaluation of extent of meningioma and response of lesions to radiosurgery (Liu et al, 2010). …”

Section: Integration Of Multimodal Neuroimaging Studies Into Treatmenmentioning

confidence: 99%

Role of Neuroimaging in Brain Radiosurgery

Koga¹,

Saito²

2012

Neuroimaging - Clinical Applications

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1-¹¹C-Acetate Versus ¹⁸F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery

Cited by 50 publications

References 39 publications

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Simultaneous 68Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience

Role of Neuroimaging in Brain Radiosurgery

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1-11C-Acetate Versus 18F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery

Cited by 50 publications

References 39 publications

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Simultaneous 68Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience

Role of Neuroimaging in Brain Radiosurgery

Contact Info

Product

Resources

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1-¹¹C-Acetate Versus ¹⁸F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery