Regional Gastrointestinal Motility in Healthy Children

Brinck, Christian Emil; Mark, Esben Bolvig; Ejerskov, Cecilie; Johansen, Klaus Birkelund; Sutter, Nanna; Schlageter, Vincent; Drewes, Asbjørn Mohr; Krogh, Klaus

doi:10.1097/mpg.0000000000003198

Cited by 5 publications

(5 citation statements)

References 36 publications

(48 reference statements)

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“…Only a small minority of children complained of abdominal pain or vomiting, though we did not record any objective organic data related to these symptoms nor the clinical picture was severe enough to require surgery. The mean time from ingestion to expulsion of 29 hours almost coincides with the reported mean whole gut transit time in healthy children (14,15). We did not observe adverse effects related to the use of fecal softeners, making them a safe option to accelerate intestinal transit and shorten the length of hospital stay.…”

Section: Discussionsupporting

confidence: 82%

“…Over the study period 3168 children were admitted for FBs ingestion, of whom 580 (18.3%) have ingested sharp/pointed objects (males/females: 292/288; age range: 11–168 months; mean age ± standard deviation: 50.5 ± 42 months). Out of these, 16 of 580 (2.8%) were infants (<1 year), 258 of 580 (44.5%) were toddlers (1–3 years), 126 of 580 (21.7%) were pre-school age children (3–5 years), and 146 of 580 (25%) were school-age children (5–12 years) and 34 of 580 (6%) were adolescent (12–18) (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

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Sharp-Pointed Foreign Body Ingestion in Pediatric Age

Quitadamo

Battagliere

Bene

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: To assess the clinical complications reported after the ingestion of sharp/pointed foreign bodies (FBs) in pediatric age, their incidence among all FB ingestions, and the features and clinical presentation of children. Study design:We have recruited all consecutive patients aged 0-14 years, admitted for sharp/pointed FB ingestion. Clinical data until hospital discharge were accurately recorded, including both children with esophagogastric FB retention who underwent endoscopic removal and children who were radiologically followed-up till spontaneous FB expulsion. Clinical outcomes were recorded for each patient, with special reference to possible prolonged retention and wall perforation during the intestinal passage. Results:We have enrolled 580 children (males/females: 292/288; age range: 11-180 months; mean age ± standard deviation: 50.5 ± 42 months). Sharp/ pointed FBs mainly included fragments of metal 270 of 580 (46.55%) and glass 180 of 580 (31%). FBs were endoscopically removed in 79 of 580 (13.6%) children whereas the remaining FBs passed through the gastrointestinal tract over an overall mean time of 29 hours. No cases of intestinal perforation nor prolonged retention were observed. In 3 of 65 (4.6%) procedures the endoscopist faced an uncomfortable endoscopic removal due to the shape and size of the FB which hampered the retrograde passage through the esophageal sphincters. Conclusions: Our original and extensive data emphasize that accidental ingestion of sharp/pointed FB ingestion is a current issue in pediatric age, especially in toddlers. Metal and glass objects are the most involved FBs and their endoscopic retrieval may not be easy in about 5% of cases. Fortunately, in our pediatric sample no surgical intervention was needed.

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Section: Discussionsupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Sharp-Pointed Foreign Body Ingestion in Pediatric Age

Quitadamo

Battagliere

Bene

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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“…The Motilis 3D-Transit system is a superior alternative, as it provides exact information about the location of the capsule in the GI tract though an ambulatory electromagnetic wireless capsule system. Although the Motilis 3D-Transit system has been trialed in children [26], it is not yet clinically available and is only offered at specialist centers [27].…”

Section: Methods For Assessment Of Enteric Neuropathymentioning

confidence: 99%

Early Gastrointestinal Neuropathy Assessed by Wireless Motility Capsules in Adolescents with Type 1 Diabetes

Rasmussen

Thrysøe

Karlsson

et al. 2023

JCM

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Background: To assess the prevalence of objective signs of gastrointestinal (GI) autonomic neuropathy (AN) in adolescents with type 1 diabetes (T1D). In addition, to investigate associations between objective GI findings and self-reported symptoms or other findings of AN. Methods: Fifty adolescents with T1D and 20 healthy adolescents were examined with a wireless motility capsule to assess the total and regional GI transit times and motility index. GI symptoms were evaluated with the GI Symptom Rating Scale questionnaire. AN was evaluated with cardiovascular and quantitative sudomotor axon reflex tests. Results: There was no difference in GI transit times in adolescents with T1D and healthy controls. Adolescents with T1D had a higher colonic motility index and peak pressure than the controls, and GI symptoms were associated with low gastric and colonic motility index (all p < 0.05). Abnormal gastric motility was associated with the duration of T1D, while a low colonic motility index was inversely associated with “time in target range” for blood glucose (all p < 0.01). No associations were found between signs of GI neuropathy and other measures of AN. Conclusions: Objective signs of GI neuropathy are common in adolescents with T1D and it seems to require early interventions in patients at high risk of developing GI neuropathy.

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“…The electromagnetic Motilis 3D-Transit system (3D-Transit) is a radiation-free and minimally invasive tool that allows an ambulatory assessment of both whole gut and regional transit times under near-normal physiological conditions (48). Its utility and normative values have been established in both adults and children (48)(49)(50)(51). More recently, wireless motility capsules have been validated for use in children (≥8 years old) to evaluate GI motility and transit simultaneously (52).…”

Section: Less Invasive Investigative Toolsmentioning

confidence: 99%

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Chanpong

Thapar

2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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The field of pediatric neurogastroenterology and motility encompasses some of the most common and severe gastrointestinal (GI) disorders that affect children. GI motility disorders remain, in general, poorly understood, variably diagnosed, and inadequately treated. Although the field progressed relatively slowly over the last decades, the coming years will, no doubt, see it move into a prolific and dynamic era. With this review, we look forward to this brighter future for the field and highlight emerging areas that show promise and deserve focus in the coming years. This includes the role of early life programming and insult of the enteric neuromusculature as a key determinant of motility diseases and factors that are likely to be relevant in disease etiopathogenesis. We discuss several recent and futuristic developments and advancements in investigative and diagnostic tools as well as novel approaches that have been introduced in the management of GI motility disorders. These include targeted and personalized medicine in both pharmacological and multidisciplinary approaches as well as the emerging therapeutic options such as bioelectrical neuromodulation and regenerative medicine.

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Regional Gastrointestinal Motility in Healthy Children

Cited by 5 publications

References 36 publications

Sharp-Pointed Foreign Body Ingestion in Pediatric Age

Sharp-Pointed Foreign Body Ingestion in Pediatric Age

Early Gastrointestinal Neuropathy Assessed by Wireless Motility Capsules in Adolescents with Type 1 Diabetes

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

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